499-78-5 Usage
Uses
Used in Pharmaceutical Industry:
5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid is used as a building block for the synthesis of complex organic molecules, particularly in the pharmaceutical industry. Its unique structure allows it to be a key component in the development of new drugs with specific therapeutic properties.
Used in Regenerative Medicine:
In the field of regenerative medicine, 5-hydroxy-4-oxo-4H-pyran-2-carboxylic acid is used as an active ingredient in anti-inflammatory compositions. Its incorporation into these compositions aids in reducing inflammation and promoting tissue repair and regeneration.
Used in Chemical Synthesis:
5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid serves as a valuable building block for an intramolecular olefin-α-pyrone cycloaddition, which is a crucial step in providing the colchicine ring skeleton. This skeleton is essential for the synthesis of colchicine, a naturally occurring alkaloid with significant medicinal properties.
Check Digit Verification of cas no
The CAS Registry Mumber 499-78-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,9 and 9 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 499-78:
(5*4)+(4*9)+(3*9)+(2*7)+(1*8)=105
105 % 10 = 5
So 499-78-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H4O5/c7-3-1-5(6(9)10)11-2-4(3)8/h1-2,8H,(H,9,10)
499-78-5Relevant articles and documents
Design, synthesis and biological evaluation of novel DNA gyrase inhibitors and their siderophore mimic conjugates
Baran?oková, Michaela,Cruz, Cristina D.,Ila?, Janez,Kikelj, Danijel,Lamut, Andra?,Ma?i?, Lucija Peterlin,Skok, ?iga,Tammela, P?ivi,Toma?i?, Tihomir,Zega, Anamarija,Zidar, Nace
, (2020/01/08)
Bacterial DNA gyrase is an important target for the development of novel antibacterial drugs, which are urgently needed because of high level of antibiotic resistance worldwide. We designed and synthesized new 4,5,6,7-tetrahydrobenzo[d]thiazole-based DNA gyrase B inhibitors and their conjugates with siderophore mimics, which were introduced to increase the uptake of inhibitors into the bacterial cytoplasm. The most potent conjugate 34 had an IC50 of 58 nM against Escherichia coli DNA gyrase and displayed MIC of 14 μg/mL against E. coli ΔtolC strain. Only minor improvements in the antibacterial activities against wild-type E. coli in low-iron conditions were seen for DNA gyrase inhibitor – siderophore mimic conjugates.
