50342-01-3Relevant articles and documents
A highly selective and sensitive turn-on probe for aluminum(III) based on quinoline Schiff's base and its cell imaging
Zhou, Fenfen,Wang, Hongqing,Liu, Pengying,Hu, Qinghua,Wang, Yuyuan,Liu, Can,Hu, Jiangke
, p. 104 - 110 (2018)
A reversible Schiff's base fluorescence probe for Al3+, (3,5-dichloro-2- hydroxybenzylidene) quinoline-2-carbohydrazide (QC), based on quinoline derivative has been designed, synthesized and evaluated. The QC exhibited a high sensitivity and se
A simple benzimidazole quinoline-conjugate fluorescent chemosensor for highly selective detection of Ag+
Chen, Changjun,Liu, Haiyang,Zhang, Bin,Wang, Yanwei,Cai, Kai,Tan, Ying,Gao, Chunmei,Liu, Hongxia,Tan, Chunyan,Jiang, Yuyang
, p. 3980 - 3985 (2016)
A novel and simple fluorescent chemosensor (L), N-((1H-benzo[d]imidazol-2-yl)methyl)quinoline-2-carboxamide, based on quinoline benzimidazole scaffold was synthesized successfully, which had a ‘turn-on’ effect for Ag+detection in methanol/Tris buffer(1:1, v/v, pH=7.35) and exhibited a strong fluorescence emission at 357?nm (λex=300?nm). The chemosensor had high sensitivity and selectivity for Ag+even in the presence of other metal ions with the detection limit of 4.4×10?7?M, which reached the standard of World Health Organization (WHO) for drinking water (5.0×10?7?M). The mechanism of the interaction between the sensor and Ag+was investigated in detail through NMR and MALDI Mass spectra analysis.
Nα-quinaldyl-L-arginine·HCl, a new defensive alkaloid from Subcoccinella-24-punctata (Coleoptera, Coccinellidae)
Wang,Braekman,Daloze,Pasteels,Soetens,Handjieva,Kalushkov
, p. 628 - 630 (1996)
The isolation of Nα-quinaldyl-L-arginine·HCl (1) from the Coccinellidae Subcoccinella-24-punctata is reported. The structure, first established on the basis of the analysis of the spectral properties of 1, has been confirmed by synthesis. The alkaloid is of endogenous origin and markedly deterrent to ants.
Synthesis and antimicrobial study of organoiridium amido-sulfadoxine complexes
Kotzé, Timothy J.,Duffy, Sandra,Avery, Vicky M,Jordaan, Audrey,Warner, Digby F.,Loots, Leigh,Smith, Gregory S.,Chellan, Prinessa
, (2021)
Two new ligands, pyridylamido-sulfadoxine (L1) and quinolylamido-sulfadoxine (L2), were prepared by the reaction of the antimicrobial sulfadrug, sulfadoxine, with either 2-picolinic acid or 2-quinaldic acid. Subsequent reaction with a [CpxIrCl2]2 dimer (where Cpx = pentamethylcyclopentadiene, tetramethylphenylcyclopentadiene or tetramethylbiphenylcyclopentadiene) yielded six new amidosulfadoxine-derivatized iridium complexes (C1-C6) in moderate to good yields, where the ligands act as N,N’-bidentate chelators. Proton and carbon NMR spectroscopy, mass spectrometry and HPLC data were used to characterize and confirm the purity of all compounds. Aquation chemistry studies on the complexes revealed slow water substitution of the chlorido ancillary ligand. The inhibitory activities of complexes C1-C6 were determined against Mycobacterium tuberculosis (Mtb) H37Rv and Plasmodium falciparum (Pf) strains, 3D7, Dd2 and HB3, as well as the HEK cell line. The ligands showed no appreciable antimicrobial activity, with most of the complexes exhibiting weak to moderate inhibition of Pf and Mtb. However, one complex (C6) displayed potent activity against Pf 3D7 (IC50 of 0.975 μM) and the multidrug-resistant Pf Dd2 (IC50 of 0.766 μM).
Enantioselective Catalysis 74. Ligand Excess and Intermediates in the Rhodium-Catalyzed Enantioselective Hydrosilylation of Acetophenone with Pyridineoxazoline Ligands
Brunner, Henri,Brandl, Paul
, p. 919 - 930 (1991)
The enantioselective hydrosilylation of acetophenone and diphenylsilane with 2 and the cocatalysts L1 - L4 was investigated.The substitution of hydrogen in the 6-position of the pyridine ring dramatically reduces the dependence of the optical induction on ligand excess, solvent, and concentration of diphenylsilane, acetophenone, and catalyst.The 6-substituents on the pyridine ring are assumed to block one of the coordination sites of rhodium, preventing further interaction with additional ligands, solvents, substrates, and additives.
Antiangiogenic activity of 3,4-seco-cycloartane triterpenes from Thai Gardenia spp. and their semi-synthetic analogs
Pudhom, Khanitha,Nuanyai, Thanesuan,Matsubara, Kiminori,Vilaivan, Tirayut
, p. 512 - 517 (2012)
Twelve naturally occurring 3,4-seco-cycloartane triterpenes (1-12) isolated from Gardenia sootepensis and Gardenia obtusifolia, and eight semi-synthetic derivatives (13-20) were evaluated for their antiangiogenic activity on a rat aortic sprouting assay,
Patterned recognition of amines and ammonium ions by a pyridine-based helical oligoamide host
Ong, Wei Qiang,Zhao, Huaiqing,Sun, Chang,Wu, Ji'En,Wong, Zicong,Li, Sam F. Y.,Hong, Yunhan,Zeng, Huaqiang
, p. 6343 - 6345 (2012)
In response to binding to amine and ammonium guests of varying types, a pyridine-based folding oligomer displays fingerprint regions in its 1H NMR spectra that allow for the easy identification and classification of the bound guests.
Application of quinoline 2-site derivative in preparation of medicine for preventing and treating agricultural plant diseases
-
Paragraph 0018-0020, (2021/03/18)
The invention relates to the technical field of pesticide chemistry, discloses a new application of a quinoline 2-site derivative, and particularly relates to an application of the quinoline 2-site derivative in preparation of drugs for preventing and treating rape sclerotinia sclerotiorum, rhizoctonia solani, tomato botrytis cinerea, wheat fusarium graminearum and magnaporthe oryzae. The compounddisclosed by the invention is a small molecular compound which is easy to synthesize and simple in structure, and is expected to be developed into a novel agricultural bactericide.
Design and Discovery of Novel Antifungal Quinoline Derivatives with Acylhydrazide as a Promising Pharmacophore
Yang, Yu-Dong,He, Ying-Hui,Ma, Kun-Yuan,Li, Hu,Zhang, Zhi-Jun,Sun, Yu,Wang, Yu-Ling,Hu, Guan-Fang,Wang, Ren-Xuan,Liu, Ying-Qian
, p. 8347 - 8357 (2021/08/16)
Inspired by natural 2-quinolinecarboxylic acid derivatives, a series of quinoline compounds containing acylhydrazine, acylhydrazone, sulfonylhydrazine, oxadiazole, thiadiazole, or triazole moieties were synthesized and evaluated for their fungicidal activity. Most of these compounds exhibited excellent fungicidal activity in vitro. Significantly, compound 2e displayed the superior in vitro antifungal activity against Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, and Fusarium graminearum with the EC50 values of 0.39, 0.46, 0.19, and 0.18 μg/mL, respectively, and were more potent than those of carbendazim (EC50, 0.68, 0.14, >100, and 0.65 μg/mL, respectively). Moreover, compound 2e could inhibit spore germination of F. graminearum. Preliminary mechanistic studies showed that compound 2e could cause abnormal morphology of cell walls and vacuoles, loss of mitochondrion, increases in membrane permeability, and release of cellular contents. These results indicate that compound 2e displayed superior fungicidal activities and could be a potential fungicidal candidate against plant fungal diseases.
Synthesis of N-trifluoromethyl amides from carboxylic acids
Flavell, Robert R.,Liu, Jianbo,Parker, Matthew F. L.,Toste, F. Dean,Wang, Sinan,Wilson, David M.
supporting information, p. 2245 - 2255 (2021/08/12)
Found in biomolecules, pharmaceuticals, and agrochemicals, amide-containing molecules are ubiquitous in nature, and their derivatization represents a significant methodological goal in fluorine chemistry. Trifluoromethyl amides have emerged as important functional groups frequently found in pharmaceutical compounds. To date, there is no strategy for synthesizing N-trifluoromethyl amides from abundant organic carboxylic acid derivatives, which are ideal starting materials in amide synthesis. Here, we report the synthesis of N-trifluoromethyl amides from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature. Through this strategy, isothiocyanates are desulfurized with AgF, and then the formed derivative is acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method shows broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners, and should find application in the modification of advanced intermediates.
