284477-00-5 Usage
General Description
2-(Quinolin-2-yl)acetic acid, also known as quinaldinic acid, is an organic compound with the formula C11H9NO2. It is a derivative of quinoline and is a potent inhibitor of dihydrofolate reductase. Quinaldinic acid has been investigated for its potential in treating cancer and malaria due to its ability to inhibit the growth of the parasitic protozoan Plasmodium falciparum. It is also being studied for its potential neuroprotective effects and its role in the pathology of neurodegenerative diseases such as Alzheimer's and Huntington's. Additionally, quinaldinic acid has been found to play a role in neuroinflammation and is associated with various neurological disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 284477-00-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,4,4,7 and 7 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 284477-00:
(8*2)+(7*8)+(6*4)+(5*4)+(4*7)+(3*7)+(2*0)+(1*0)=165
165 % 10 = 5
So 284477-00-5 is a valid CAS Registry Number.
284477-00-5Relevant articles and documents
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides
Baruah, Pranjal K.,Dinsmore, Jason,King, Amber M.,Salomé, Christophe,De Ryck, Marc,Kaminski, Rafal,Provins, Laurent,Kohn, Harold
supporting information; experimental part, p. 3551 - 3564 (2012/07/28)
N-Benzyl 2-acetamido-2-substituted acetamides, where the 2-substituent is a (hetero)aromatic moiety, are potent anticonvulsants. We report the synthesis and whole animal pharmacological evaluation of 16 analogues where the terminal 2-acetyl group was removed to give the corresponding primary amino acid derivatives (PAADs). Conversion to the PAAD structure led to a substantial drop in seizure protection in animal tests, demonstrating the importance of the N-acetyl moiety for anticonvulsant activity. However, several of the PAADs displayed notable pain-attenuating activities in a mouse model.
