50461-74-0

Basic information

• Product Name: Ethyl 2-oxovalerate
• Synonyms: Ethyl 2-oxovalerate;2-OXO-PENTANOIC ACID ETHYL ESTER;Ethyl-2-oxo-pentanoate;2-OXO-PENTAROIC ACID ETHYL ESTER;2-Oxovalericacidethylester;2-OXO-PENTAROIC ACID ETHYL ESTER, >95%;PENTANOICACID,2-OXO-,ETHYLESTER;2-Oxyvaleric acid ethyl ester
• CAS NO: 50461-74-0
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.17
• EINECS: 256-593-3
• Product Categories: API
• Mol File: 50461-74-0.mol

Chemical Properties

• Boiling Point: 182.5°C (estimate)
• Flash Point: 71.4 °C
• Appearance: Light yellow oil liquid
• Density: 0.9985
• Vapor Pressure: 0.808mmHg at 25°C
• Refractive Index: 1.4170
• Storage Temp.: 2-8°C
• Solubility: Chloroform, DMSO, Methanol
• CAS DataBase Reference: Ethyl 2-oxovalerate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-oxovalerate(50461-74-0)
• EPA Substance Registry System: Ethyl 2-oxovalerate(50461-74-0)

Safety Data

• Hazardous Substances Data: 50461-74-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H12O3/c1-3-5-6(8)7(9)10-4-2/h3-5H2,1-2H3

Upstream product

• 26103-77-5 2-Ethyl-3-oxo-succinic acid diethyl ester 
• 14273-07-5 1-ethoxy-pent-1-yne 
• 927-77-5 n-propylmagnesium bromide 
• 95-92-1 oxalic acid diethyl ester 
• 64-17-5 ethanol 
• 1821-02-9 2-oxopentanoic acid 
• 79584-44-4 Ethyl 2-azido pentanoate 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 3249-68-1 ethyl butyroyl acetate 
• 615-83-8 2-bromo-pentanoic acid ethyl ester 
• 69461-35-4 N-(1-oxo-1-aethoxy-2-pentyl)-N-phenyl-N-trifluormethansulfonamid 

Downstream Products

• 113264-43-0 3-bromo-2-oxo-pentanoic acid ethyl ester 
• 88945-70-4 ethyl 2-hydroxy-n-valerate 
• 129546-84-5 (E)-ethyl 2-[2-(4-nitrophenyl)hydrazono]pentanoate 
• 13074-61-8 2-propylmaleic acid 
• 5469-28-3 n-propylfumaric acid 
• 5796-70-3 2-propylidenesuccinic acid 
• 200286-28-8 2-Oxo-3-phenylselanyl-pentanoic acid ethyl ester 
• 82834-16-0 Perindopril 
• 122454-52-8 (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid benzyl ester 
• 178041-62-8 3,4-dihydro-3-propyl-1H-quinoxalin-2-one 
• 110038-75-0 2-propyltetrahydroquinoxaline 
• 1361569-68-7 4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-propylpteridin-7(8H)-one 
• 864550-62-9 5-bromo-8-methyl-1-propyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indole-1,7-dicarboxylic acid 7-benzyl ester 1-ethyl ester 
• 129546-85-6 Ethyl 2-(4-nitrophenylhydrazono)valerat 

Relevant articles and documents

MICROCAPSULES CONTAINING A GAS-GENERATING PHOTOLABILE KETOACID OR KETOESTER AND USES THEREOF

The present invention relates to water-dispersable microcapsules comprising an oil phase, e.g. a perfume, containing a photolabile α-ketoacid or α-ketoester capable of generating a gas upon exposure to light. The gas is able to cause an extension or the breaking of the microcapsule allowing the release of the oil phase and thus increasing the long-lastingness of the odor perception. The present invention concerns also the use of said microcapsules in perfumery as well as the perfuming compositions or perfumed articles comprising the invention's microcapsules to provide a prolonged release of fragrant molecules.

Oxone-mediated oxidative cleavage of β-keto esters and 1,3-diketones to α-keto esters and 1,2-diketones in aqueous medium

A versatile and highly efficient method for the direct synthesis of α-keto esters and 1,2-diketones has been developed. This approach utilizes the oxidative cleavage of a variety of β-keto esters and 1,3-diketones mediated by an Oxone/aluminum trichloride system. The simple one-step oxidation reaction proceeded selectively in aqueous media to afford products in high yields, short reaction times, and environmentally benign conditions.

HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE

The present invention relates to a compound represented by a formula (I): wherein X is a group represented by or the like; Y is a group represented by or the like; and Ar1 is a group represented by or a pharmaceutically acceptable salt thereof.

Continuous flow based catch and release protocol for the synthesis of α-ketoesters

Using a combination of commercially available mesofluidic flow equipment and tubes packed with immobilised reagents and scavengers, a new synthesis of a-ketoesters is reported.

PROCESS FOR PREPARING a-KETO ACIDS AND DERIVATIVES THEREOF

A method for preparing α-keto acids, especially α-ketomethionine, and/or derivatives thereof, whereby an aldehyde is reacted with thiols to give a corresponding dithioacetal, the dithioacetal formed, is reacted with an electrophile in the presence of a strong base, and the resulting α,α-(dithio)carboxylic acid is solvolyzed with acid-catalysis to release thiol and give the α-keto acid or a derivative thereof. Umpolung of aliphatic or aromatic aldehydes is effected by reaction with thiols.

PROCESS FOR PRODUCING ALPHA-OXOCARBONYL COMPOUND

A process by which an α-oxocarbonyl compound useful as an intermediate for pharmaceuticals/agricultural chemicals can be industrially advantageously and efficiently produced in a high yield. The process, which is for producing an α-oxocarbonyl compound represented by the general formula (I) wherein R1 and R2 are as defined in the description, comprises oxidizing an α-hydroxycarbonyl compound represented by the general formula (II) , with oxygen or air in the presence of a carboxylic acid and at least one vanadium compound selected from divanadium pentaoxide, divanadium trioxide, divanadium tetraoxide, ammonium metavanadate, sodium metavanadate, potassium metavanadate, triethoxyoxovanadium, tripropoxyoxovanadium, triisopropoxyoxovanadium, vanadium oxobis(acetylacetonate) and vanadium tris(acetylacetonate).

Synthesis and reactivity of β-phenylselanyl α-oxoesters

β-Phenylsetanyl α-oxoesters 2 were prepared by N-phenylselanyl morpholine treatment of α-oxoesters 1, oxidized into β-unsaturated α- oxoesters 5 and subjected to the Wittig-Horner olefination. The diethyl (l- phenylselanylalkyl)maleates 6 have led, after [2,3]sigmatropic rearrangement of the corrsponding selenoxides to the diethyl 3-alkylidene-2- hydroxysuccinates 7. The 2-(1-butoxycarbonylamino)-3-alkylidenesuccinates 8 were prepared in a similar way. The decomposition of halo-adducts derived from components 6 has the synthesis of the siethyl 3-alkylidene-2- halosuccinates 9 and 10.

Stereochemical Control on Yeast Reduction of α-Keto Esters. Reduction by Immobilized Bakers' Yeast in Hexane

Ethyl 2-oxoheptanoate has been reduced by three methods: free bakers' yeast (FBY) in water, immobilized bakers' yeast (IMBY) in water, and IMBY in hexane.It has been found that the stereochemistry of reduction of α-keto esters by bakers' yeast is controlled by appropiate choice of reaction conditions.