51727-15-2

Basic information

• Product Name: 4-Chloropyridine-2-carbonyl Chloride Hydrochloride
• Synonyms: 4-Chloro-2-pyridinecarbonyl Chloride Hydrochlorid;(4-Chloro-2-pyridinecarbonyl Chloride Hydrochloride);2-Pyridinecarbonyl chloride, 4-chloro-, hydrochloride;4-chloropicolinoyl chloride hydrochloride;2-Pyridinecarbonyl chloride, 4-chloro-, hydrochloride (1:1)
• CAS NO: 51727-15-2
• Molecular Formula: C6H4Cl3NO
• Molecular Weight: 0
• EINECS: 1592732-453-0
• Product Categories: Aromatics;Heterocycles
• Mol File: 51727-15-2.mol

Chemical Properties

• Melting Point: 135-137°C (dec.)
• Appearance: /
• Storage Temp.: -20?C Freezer, Under Inert Atmosphere
• CAS DataBase Reference: 4-Chloropyridine-2-carbonyl Chloride Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloropyridine-2-carbonyl Chloride Hydrochloride(51727-15-2)
• EPA Substance Registry System: 4-Chloropyridine-2-carbonyl Chloride Hydrochloride(51727-15-2)

Safety Data

• Hazardous Substances Data: 51727-15-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloropyridine-2-carbonyl Chloride Hydrochloride is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 4-Chloropyridine-2-carbonyl Chloride Hydrochloride is employed as a reagent to study the properties and reactions of different organic molecules. Its versatility in forming various chemical bonds makes it a valuable tool for understanding the underlying mechanisms of organic reactions.
Used in Organic Synthesis:
4-Chloropyridine-2-carbonyl Chloride Hydrochloride is used as a synthetic building block for the creation of complex organic molecules. Its presence in the synthesis process enables the formation of a wide range of compounds with diverse applications, including those in the pharmaceutical, agrochemical, and materials science industries.
Used in Material Science:
In the field of material science, 4-Chloropyridine-2-carbonyl Chloride Hydrochloride is utilized as a precursor for the development of novel materials with specific properties. These materials can be tailored for various applications, such as in electronics, optics, and energy storage.
Overall, 4-Chloropyridine-2-carbonyl Chloride Hydrochloride is a versatile compound with a wide range of applications across different industries, primarily due to its unique chemical properties and its role as a synthetic building block in organic synthesis.

Upstream product

• 98-98-6 2-Picolinic acid 

Downstream Products

• 1090815-16-9 N-cyclopropyl-4-chloro-2-pyridinecarboxamide 
• 604813-08-3 N-isopropyl-4-chloro-2-pyridinecarboxamide 
• 1338443-27-8 N-methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide 4-methylbenzenesulfonate 
• 1125780-43-9 N-methyl-4-(4-(4-(trifluoromethyl)benzamido)phenoxy)picolinamide 
• 284461-74-1 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-2-pyridine carboxamide 
• 1125780-41-7 N-methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide 
• 1290546-55-2 4-(4-(3-(5-chloro-2-fluorophenyl)ureido)phenoxy)-N-methylpicolinamide 

Relevant articles and documents

A new pathway via intermediate 4-amino-3-fluorophenol for the synthesis of regorafenib

A practical synthetic route to regorafenib, in which the target compound was obtained via a 10-step synthesis starting from 2-picolinic acid, 4-chloro-3-(trifluoromethyl)aniline, and 3-fluorophenol, is reported. Crucial to the strategy is the preparation of 4-amino-3-fluorophenol via Fries and Beckman rearrangements using an economical and practical protocol. The main advantages of the route include inexpensive starting materials and an acceptable overall yield. A scale-up experiment was carried out to provide regorafenib with 99.96% purity in 46.5% total yield.