51795-97-2

Basic information

• Product Name: 6-PHENOXYHEXYL BROMIDE
• Synonyms: AURORA KA-3137;1-BROMO-6-PHENOXYHEXANE;6-PHENOXYHEXYL BROMIDE;6-Bromohexyl Phenyl Ether;[(6-bromohexyl)oxy]benzene;((6-Bromohexyl)
• CAS NO: 51795-97-2
• Molecular Formula: C₁₂H₁₇BrO
• Molecular Weight: 257.17
• Product Categories: Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds
• Mol File: 51795-97-2.mol

Chemical Properties

• Boiling Point: 320.3°C at 760 mmHg
• Flash Point: 126.2°C
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 0.000602mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: 6-PHENOXYHEXYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-PHENOXYHEXYL BROMIDE(51795-97-2)
• EPA Substance Registry System: 6-PHENOXYHEXYL BROMIDE(51795-97-2)

Safety Data

• Hazardous Substances Data: 51795-97-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-PHENOXYHEXYL BROMIDE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agricultural Chemical Industry:
6-PHENOXYHEXYL BROMIDE is used as a precursor in the production of agricultural chemicals, contributing to the development of effective pest control agents and other agrochemicals.
Used in Organic Synthesis:
6-PHENOXYHEXYL BROMIDE is used as a versatile building block in organic synthesis for the creation of a wide range of organic compounds, including specialty chemicals and advanced materials.

InChI:InChI=1/C12H17BrO/c13-10-6-1-2-7-11-14-12-8-4-3-5-9-12/h3-5,8-9H,1-2,6-7,10-11H2

Upstream product

• 629-03-8 1 ,6-dibromohexane 
• 139-02-6 sodium phenoxide 
• 16654-54-9 6-phenoxyhexan-1-ol 
• 108-95-2 phenol 
• 75612-73-6 1-bromo-4-(6-bromohexyloxy)benzene 
• 4286-55-9 1-bromo-6-hexanol 
• 7170-41-4 6-phenoxyhexanoic acid 
• 2009-83-8 6-chloro-1-hexanol 
• 63649-95-6 6-phenoxyhexyl methanesulfonate 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 99-96-7 4-hydroxy-benzoic acid 

Downstream Products

• 857787-75-8 ethyl 7-(phenoxy)heptanoate 
• 71933-97-6 dimethyl-(6-phenoxy-hexyl)-amine 
• 220077-58-7 diethyl 2-(6-phenoxyhexyl)propanedioate 
• 7170-42-5 7-phenoxy-heptanoic acid 
• 16728-58-8 7-phenoxy-heptanenitrile 
• 102011-09-6 1-Phenoxy-6-(4-nitro-2-methoxy-phenoxy)-hexan 
• 51796-01-1 1-(2-methoxyphenyl)-7-phenoxyheptane 
• 19100-98-2 (5-phenoxypentyl)triphenylphosphonium bromide 
• 98263-71-9 3-Methyl-5-(7-phenoxy-heptyl)-isoxazole 
• 63359-97-7 1-[2-Hydroxy-4-(6-phenoxy-hexyloxy)-phenyl]-ethanone 
• 69782-12-3 6-Phenoxy-hexylhydrazin 
• 196311-13-4 11-Phenoxy-5-oxaundecan-1-ol 
• 1132-66-7 1-phenoxyhexane 
• 74972-56-8 (hex-5-en-1-yloxy)benzene 

Relevant articles and documents

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A copper-catalyzed alkoxycarbonylation transformation of unactivated alkyl iodides has been developed. Various alkyl iodides can be converted into the corresponding tert-butyl esters in good yields. NaOtBu acts as both a nucleophile and a base. Moreover, other types of aliphatic esters can also be obtained in moderated yields if extra alcohols are added. Both primary and secondary alkyl alcohols can react successfully.

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CHEMOSELECTIVE SENSITIVITY BOOSTER FOR TAGGING A PEPTIDE, PEPTIDE CONJUGATE, OR SIMILAR REACTIVE MOLECULE

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Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology

Chemical biology research often requires precise covalent attachment of labels to the native proteins. Such methods are sought after to probe, design, and regulate the properties of proteins. At present, this demand is largely unmet due to the lack of empowering chemical technology. Here, we report a chemical platform that enables site-selective labeling of native proteins. Initially, a reversible intermolecular reaction places the "chemical linchpins" globally on all the accessible Lys residues. These linchpins have the capability to drive site-selective covalent labeling of proteins. The linchpin detaches within physiological conditions and capacitates the late-stage installation of various tags. The chemical platform is modular, and the reagent design regulates the site of modification. The linchpin is a multitasking group and facilitates purification of the labeled protein eliminating the requirement of additional chromatography tag. The methodology allows the labeling of a single protein in a mixture of proteins. The precise modification of an accessible residue in protein ensures that their structure remains unaltered. The enzymatic activity of myoglobin, cytochrome C, aldolase, and lysozyme C remains conserved after labeling. Also, the cellular uptake of modified insulin and its downstream signaling process remain unperturbed. The linchpin directed modification (LDM) provides a convenient route for the conjugation of a fluorophore and drug to a Fab and monoclonal antibody. It delivers trastuzumab-doxorubicin and trastuzumab-emtansine conjugates with selective antiproliferative activity toward Her-2 positive SKBR-3 breast cancer cells.

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