52927-23-8

Basic information

• Product Name: 5-Bromo-1-naphthol
• Synonyms: 5-Bromo-1-naphthol;5-Bromonaphthalen-1-ol;5-Bromo-1-phthol
• CAS NO: 52927-23-8
• Molecular Formula: C₁₀H₇BrO
• Molecular Weight: 223.07
• Mol File: 52927-23-8.mol

Chemical Properties

• Melting Point: 137 °C
• Boiling Point: 353.8±15.0 °C(Predicted)
• Appearance: /
• Density: 1.614±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.93±0.40(Predicted)
• CAS DataBase Reference: 5-Bromo-1-naphthol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-1-naphthol(52927-23-8)
• EPA Substance Registry System: 5-Bromo-1-naphthol(52927-23-8)

Safety Data

• Hazardous Substances Data: 52927-23-8(Hazardous Substances Data)

Upstream product

• 148378-71-6 2,7-dibromo-3,4-dihydronaphthalen-1(2H)-one 
• 345995-25-7 2,5-dibromo-3,4-dihydro-1(2H)-naphthalenone 
• 1745-81-9 o-Allylphenol 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 68449-30-9 5-bromo-1-tetralone 
• 5328-76-7 1-bromo-5-nitronaphthalene 
• 86-57-7 1-Nitronaphthalene 
• 108-36-1 1,3-dibromobenzene 
• 41498-06-0 5-bromo-1-naphthaldehyde 
• 90-11-9 1-Bromonaphthalene 
• 136131-50-5 5-bromo-1,4-dihydro-1,4-epoxynaphthalene 
• 103030-24-6 5-bromo-[1]naphthylamine; hydrochloride 
• 4766-33-0 5-amino-1-bromonaphthalene 

Downstream Products

• 74924-95-1 1-bromo-5-methoxynaphthalene 
• 861640-60-0 (4S)-3-[3-(5-hydroxy-1-naphthalenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2-oxazolidinone 
• 1374750-74-9 1-benzyloxy-5-(2-hydroxy-2-adamantyl)naphthalene 
• 1094215-68-5 1-(benzyloxy)-5-bromonaphthalene 
• 1303519-21-2 1-hydroxy-4-{3,5-(diphenyl)phenyl}naphthalene 
• 51934-37-3 5-methoxy-1-naphthoic acid 
• 1027160-14-0 5-Ethyl-2-methoxy-naphthalen-1-ol 
• 861640-71-3 C₆₇H₉₆N₇O₁₃PS 
• 861640-69-9 (βS,γS)-β-[[1-[[(1S)-3-amino-1-[[(2S)-2-(5-hydroxy-1-naphthalenylmethyl)-4-pentenyl]aminocarbonyl]-3-oxopropyl]aminocarbonyl]cyclohexyl]aminocarbonyl]-4-[4-[bis(tert-butoxy)phosphoryl]methyl]-γ-ethenylbenzenebutanoic acid 1,1-dimethylethyl ester 
• 861640-70-2 (9S,10S,11E,14S,18S)-18-(2-amino-2-oxoethyl)-10-[[4-[bis(1,1-dimethylethoxy)phosphoryl]methyl]phenyl]-14-(1-(5-hydroxy)naphthalenylmethyl)-8,17,20-trioxo-7,16,19-triazaspiro[5.14]eicos-11-en-9-acetic acid 1,1-dimethylethyl ester 
• 861640-68-8 (2S)-2-[[(1-aminocyclohexyl)carbonyl]amino]-N¹-[(2S)-2-(5-hydroxy-1-naphthalenylmethyl)-4-pentenyl]butanediamide 
• 861640-63-3 (4S)-3-[(2S)-2-(5-(2-(trimethylsilyl)ethyl)oxy-1-naphthalenylmethyl)-1-oxo-4-penten-1-yl]-4-phenyl-2-oxazolidinone 
• 861640-62-2 (4S)-3-[3-(5-(2-(trimethylsilyl)ethyl)oxy-1-naphthalenyl)-1-oxo-2-propan-1-yl]-4-phenyl-2-oxazolidinone 
• 861640-61-1 (4S)-3-[3-(5-(2-(trimethylsilyl)ethyl)oxy-1-naphthalenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2-oxazolidinone 

Relevant articles and documents

A Visible Light and Iron-mediated Carbocationic Route to Polysubstituted 1-Halonaphthalenes by Benzannulation using Allylbenzenes and Polyhalomethanes

A wide array of polysubstituted 1-bromo and chloronaphthalenes are obtained from coupling of allylbenzenes and polyhalomethanes. The reaction is mediated by iron metal under visible light irradiation and proceeds via a Kharasch addition intermediate followed by intramolecular FeIII mediated Friedel-Crafts alkylation, with the formation of two Csp2?Csp2 bonds in the process. This method gives easy access to 1-halonaphthalenes with substituent(s) at C-5 to C-8 that are otherwise hard to synthesize. (Figure presented.).

9-AZABICYCLO [3 . 3 . 1] NONANE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS

The present invention relates to a 9-azabicyclo[3.3.1]nonane derivative of formula (I), wherein R1 is H or C1-5alkyl; X is O or NR2, wherein R2 is H, C1-5alkyl or C2-5acyl and Ar is C6-10aryl or a 5-10 membered heteroaryl ring system, both being optionally substituted with one to three of R3-R5 independently selected from halogen, C1-5alkyl, C1-5alkoxy, C3-6cycloalkyl, C2-5alkenyl, C2-5alkynyl, CN, NO2, hydroxy, phenyl, phenoxy and phenylC1-2alkoxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein said phenyl, phenoxy and phenylC1-2alkoxy are optionally substituted with one to three substituents independently selected from halogen and methyl or two of R3-R5 at adjacent positions together form a methylenedioxy or propylene unit, with the proviso that the compounds exo-9-methyl-3-phenoxy-9-azabicyclo[3.3.1]nonane and N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H indazole-5-amine are excluded, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 9-azabicyclo[3.3.1]nonane derivatives and to their use in therapy.

Indole derivatives for the treatment of depression and anxiety

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Piperidines derivatives and their use as serotonin receptor antagonists

The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.

Benzofuran derivatives

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New chiral synthons from the microbial oxidation of bromonaphthalenes

1-Bromo- and 2-bromonaphthalene were subjected to bio-oxidation with whole cells of Pseudomonas putida NCIB 9816-11. The major metabolites were isolated and spectroscopically characterized as (+)-cis-(1R,2S)-Dihydroxy-1,2-dihydro-8-bromonaphthalene 1, (+)-cis-(1R,2S)-Dihydroxy-1,2-dihydro-5-bromonaphthalene 2 from 1-bromonaphthalene and (+)-cis-(1R,2S)-Dihydroxy-1,2-dihydro-7-bromonaphthalene 8 from 2-bromonaphthalene. The absolute stereochemistry and enantiomeric excess were determined by conversion of each metabolite to the known (-)-cis-tetrahydronaphthalene diol 6.

The Baeyer-Villiger Oxidation of Aromatic Aldehydes and Ketones with Hydrogen Peroxide Catalyzed by Selenium Compounds

A series of organoselenium compounds was investigated as activators of hydrogen peroxide in the Baeyer-Villiger oxidation.As a result, a convenient and cheap method for transformation of aromatic aldehydes, having polycondensed ring systems or electron-donating substituents, and polymethoxy derivatives of acetophenone, into phenols was elaborated.This method utilizes hydrogen peroxide activated by areneseleninic acids, as oxidizing agent.