53981-69-4

Basic information

• Product Name: 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL
• Synonyms: 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL;Ethanone, 1-(1H-imidazol-2-yl)- (9CI);2-ACETYLIMIDAZOLE;1-(1H-imidazol-2-yl)ethanone(SALTDATA: FREE);1-(1H-Imidazol-2-yl)-1-ethanone
• CAS NO: 53981-69-4
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11394
• Product Categories: ACETYLGROUP
• Mol File: 53981-69-4.mol

Chemical Properties

• Melting Point: 136-138℃
• Boiling Point: 269.4 °C at 760 mmHg
• Flash Point: 120.8 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 0.00727mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 11.11±0.10(Predicted)
• CAS DataBase Reference: 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL(53981-69-4)
• EPA Substance Registry System: 1-(1H-IMIDAZOL-2-YL)-ETHANONE HCL(53981-69-4)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 53981-69-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-(1H-Imidazol-2-YL)-ETHANONE HCL is used as a reagent for facilitating various chemical reactions in organic synthesis. Its imidazole ring provides a platform for the formation of intermediates and final products, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(1H-Imidazol-2-YL)-ETHANONE HCL is utilized as a research tool to explore its potential in drug development. Its unique chemical properties allow it to be a candidate for the creation of new pharmaceutical agents, particularly those targeting specific biological pathways or receptors.
Used in the Preparation of Pharmaceuticals:
1-(1H-Imidazol-2-YL)-ETHANONE HCL is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its presence in the molecular structure of these compounds can contribute to their therapeutic effects, making it an essential component in the development of new medications.
Used in Agrochemicals:
In the agrochemical sector, 1-(1H-Imidazol-2-YL)-ETHANONE HCL is employed in the development of crop protection products and other agricultural chemicals. Its chemical properties may be harnessed to create compounds that protect crops from pests and diseases, thereby increasing agricultural productivity.
Used in Specialty Chemicals:
1-(1H-Imidazol-2-YL)-ETHANONE HCL is also used in the production of specialty chemicals, which are tailored for specific applications in various industries. Its unique structure and reactivity make it suitable for creating high-value chemical products with specialized functions.

InChI:InChI=1/C5H6N2O/c1-4(8)5-6-2-3-7-5/h2-3H,1H3,(H,6,7)

Upstream product

• 875553-56-3 1-(1-tosyl-1H-imidazol-2-yl)ethan-1-one 
• 1100723-57-6 (Z)-1-[2-(p-tolyl)hydrazono]-1-(1H-1,2,3-triazol-1-yl)propanone 
• 1100723-55-4 (Z)-1-[2-(4-chlorophenyl)hydrazono]-1-(1H-1,2,3-triazol-1-yl)propanone 
• 1100723-54-3 (Z)-1-(2-phenylhydrazono)-1-(1H-1,2,3-triazol-1-yl)propanone 
• 127-19-5 N,N-dimethyl acetamide 
• 61278-81-7 1-(diethoxymethyl)-1H-imidazole 
• 2466-76-4 N-Acetylimidazole 
• 22098-61-9 1-(1H-imidazol-2-yl)ethan-1-ol 
• 75-16-1 methylmagnesium bromide 
• 31722-49-3 2-cyano imidazole 

Downstream Products

• 1360148-63-5 C₂₀H₂₃N₃O₃S₂ 
• 912962-83-5 3-(3-(2-acetylimidazol-1-ylmethyl)phenyl)-5-isobutylthiophene-2-(N-tert-butyl)sulfonamide 
• 85692-37-1 1-(1-methyl-1H-imidazol-2-yl)ethan-1-one 
• 22098-61-9 1-(1H-imidazol-2-yl)ethan-1-ol 

Relevant articles and documents

IMIDAZOLE-BASED ANTICANCER AGENTS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND USING SAME

Imidazole-based anticancer agents and derivatives thereof, as well as methods of making and methods of using the same, are described. The imidazole-based anticancer agents are HDAC inhibitor compounds having a 1-(1H-imidazol-2-yl)ethan-1-one or 1-(1H-imidazol-2-yl)ethane-1- thione moiety.

Gas-phase pyrolysis in organic synthesis: New route for synthesis of functionally substituted imidazoles

(Chemical Equation Presented) 1,2,3-Triazolylpropanone was prepared and coupled with aryldiazonium salts yielding the corresponding arylhydrazones. Gas-phase pyrolysis of the hydrazono derivative produced N-arylamino-2- acetylimidazole as well as 2-acetyl

ARYLOXY-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES

A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided. The invention relates to a compound of a formula (I): [wherein R1 and R2 represent a hydrogen, etc.; R3 represents a hydrogen atom, a halogen atom, etc.; R4 each independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); R5 and R6 each represent a hydrogen atom, a lower alkyl group, etc.; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group β; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of X1 to X4 are carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.

PYRAZOLE DERIVATIVE

A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.

PYROLISE-ECLAIR EN PHASE GAZEUSE DU 1-ACETYLIMIDAZOLE.

1-acetylimidazole is isomerized into 2- and 4-acetylimidazoles and under flash-vacuum pyrolytic conditions.This has been demonstrated by a real-time analysis of the products using mass and ion kinetic energy spectrometries.

2-GUANIDINO-4-HETEROARYL-THIAZOLES

A series of 2-guanidino-4-heteroarylthiazoles, wherein the heteroaryl substituent is selected from thiazolyl, triazolyl, imidazolyl, and 2-alkyl, 2-amino and 2-carboxamido derivatives thereof, are disclosed. The novel compounds have activity as antisecretory agents and histamine H 2 antagonists and are useful for the treatment of gastric hyperacidity and peptic ulcers. Also disclosed are pharmaceutical compositions containing the novel compounds of this invention and a method of using the compounds in the treatment of gastric hyperacidity and peptic ulcers. Novel intermediates useful in the preparation of the novel antisecretory compounds are also described.

An Easily Introduced and Removed Protecting Group for Imidazole Nitrogen: A Convenient Route to 2-Substituted Imidazoles

Orthoamides (3-5) prepared from imidazoles and triethyl or trimethyl orthoformate are rapidly metalated at -40 deg C in THF or ether to give the corresponding 2-lithio anion which reacts with a variety of electrophiles.The dialkoxymethyl protecting group is readily hydrolyzed under neutral or acidic conditions at room temperature, giving the 2-substituted 1H-imidazole 1 (R = H, X = COOH, n-C4H9, COCH3, CHOHC6H5, C(CH3)OH-2-pyridyl,9-hydroxyfluorenyl, 1-hydroxycyclohex-2-enyl, C(OH)(C6H5)2; R = CH3, R' = H, X = CHO) and the tris(2-imidazolyl)phosphines (R = H, CH3, CH(CH3)2).A mechanism for the deprotection of 3 is proposed.