- Preparation method of chlorhexidine
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The invention discloses a preparation method of chlorhexidine. The preparation method comprises the following steps: mixing n-butyl alcohol, hexanediamine and hydrochloric acid, adding triethylamine and sodium dicyandiamide, carrying out a primary condensation reaction, adding parachloroaniline, water and hydrochloric acid after the primary condensation reaction is finished, carrying out a secondary condensation reaction, adding liquid caustic soda after the secondary condensation reaction is finished, alkalizing, crystallizing, and carrying out centrifugal filtration to obtain a chlorhexidinecrude product; and washing, carrying out centrifugal filtration, and drying to obtain chlorhexidine. According to the method, chlorhexidine is prepared by adopting a one-pot boiling principle, so that the reaction steps and the wastewater amount are reduced, the operation is simplified, and the quality and the yield are remarkably improved.
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Paragraph 0021
(2020/07/13)
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- Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL and induce apoptosis in human oral tumor cells
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Chlorhexidine and alexidine have long been used as oral disinfectants by humans. Both compounds inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL at physiologically relevant concentrations and induce apoptosis in a series of tumor cell lines derived from the tongue and pharynx (see picture). Inhibition of protein-protein interactions is a potential mode of action of drugs in current human use. Copyright
- Graeber, Martin,Hell, Michael,Groest, Corinna,Friberg, Anders,Sperl, Bianca,Sattler, Michael,Berg, Thorsten
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supporting information
p. 4487 - 4491
(2013/05/22)
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- Nanomaterial wound dressing assembly
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Wound dressing assemblies and methods of producing the wound dressing assemblies. The wound dressing assemblies various comprise individual layers of nanomaterials that have been formed according to an electrospinning process. Each of the layers can have different characteristics and qualities. The invention also provides guidance in selecting materials to form a wound dressing assembly, as well as possible adaptations to the electrospinning process to provide different characteristics for particular materials.
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- Antimicrobial Composite Material and Method for Fluid Treatment
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Composite materials with broad spectrum antimicrobial properties and methods and devices for fluid treatment utilizing said materials are provided. The antimicrobial composite materials may include combinations of activated carbon and a biguanide hydrate. A particular composition includes a mixture of carbon particles and particles of chlorhexidine hydrate, which is useful in fixed particle bed water treatment devices and methods.
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Page/Page column 10
(2009/08/14)
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- Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
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The present invention provides novel hydrogel-forming, self-solvating, absorbable polyester copolymers capable of selective, segmental association into compliant hydrogels upon contacting an aqueous environment. Methods of using the novel polyester copolymers of the invention in humans are also disclosed for providing a protective barrier to prevent post-surgical adhesion, treatment of defects in conduits such as blood vessels, and controlled release of a biologically active agent for modulating cellular events such as wound healing and tissue regeneration or therapeutic treatment of diseases such as infection of the periodontium, dry socket, bone, skin, vaginal, and nail infections.
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- Hydrogel-forming , self-solvating absorbable polyester copolymers, and methods for use therefor
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The present invention provides novel hydrogel-forming, self-solvatirig, absorbable polyester copolymers capable of selective, segmental association into compliant hydrogels upon contacting aqueous environment. Pharmaceutical formulations comprising the novel polyester copolymers of the invention are also disclosed which provide a protective barrier to prevent post-surgical adhesion, can be used to treat of defects in conduits such as blood vessels, and for controlled release of a biologically active agent for modulating cellular events such as wound healing and tissue regeneration or therapeutic treatment of diseases such as infection of the periodontium, dry socket, bone, skin, vaginal, and nail infections.
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- Intraoral medicament delivery and procedure
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A method for cushioning dental appliance in the mouth using a visible light cured polymeric material which can also be used in a method for intraoral medicament delivery in the mouth is provided. When used with an orthodontic bracket, for example, the light cured polymeric material is dispensed on the orthodontic bracket after the bracket is in place and the material is light cured on the bracket. When used in a method of intraoral delivery of a medicament, a medicament is added to the polymeric material and the polymeric material is applied in the same manner as described for cushioning an orthodontic bracket.
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- Dentifrice containing a poly(hydroxypropyl ether) non-ionic surfactant and a specified cationic polymer
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Dentifrice containing, in combination, (A) a poly(hydroxypropyl ether) nonionic surfactant, and (B) a cationic polymer selected from the group consisting of (i) a vinylpyrrolidone/dialkylaminoalkyl or -hydroxyalkyl acrylate or methacrylate, quaternized or nonquaternized and (ii) a cationic polysaccharide. This dentifrice is characterized by good foamability, pleasant taste and it does not attack the buccal mucosae and the gums.
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