552-38-5

Basic information

• Product Name: LITHIUM SALICYLATE
• Synonyms: SALICYLIC ACID LITHIUM SALT;LITHIUM SALICYLATE;2-hydroxy-benzoicacimonolithiumsalt;o-Hydroxybenzoic acid lithium salt;LITHIUM SALICYLATE, 99.99%;Lithiumsalicylate,tech.;Lithiumsalicylat;Benzoic acid, 2-hydroxy-, monolithium salt
• CAS NO: 552-38-5
• Molecular Formula: C₇H₅O₃*Li
• Molecular Weight: 144.05
• EINECS: 209-011-7
• Product Categories: Organic-metal salt;Classes of Metal Compounds;Li (Lithium) Compounds;Typical Metal Compounds
• Mol File: 552-38-5.mol

Chemical Properties

• Melting Point: >350 °C(lit.)
• Boiling Point: 336.3 °C at 760 mmHg
• Flash Point: 144.5 °C
• Appearance: /
• Density: 1.428[at 20℃]
• Water Solubility: Soluble in water
• BRN: 3732791
• CAS DataBase Reference: LITHIUM SALICYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: LITHIUM SALICYLATE(552-38-5)
• EPA Substance Registry System: LITHIUM SALICYLATE(552-38-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/38
• Safety Statements: 22-26-36
• WGK Germany: 1
• F: 3-10
• TSCA: Yes
• Hazardous Substances Data: 552-38-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Lithium salicylate is used as a therapeutic agent for the treatment of bipolar disorder and other neuropsychiatric conditions. Its ability to maintain steady lithium levels for an extended period without toxic side effects makes it a preferred choice over traditional lithium carbonate.
Used in Diuretics:
Lithium salicylate is used as a diuretic, benefiting patients who require treatment for fluid retention or high blood pressure.
Used in Catalysts for Chemiluminescent Systems:
Lithium salicylate is used as a catalyst in chemiluminescent systems, enhancing the efficiency and performance of these systems.
Used in Trimer Catalyst for Aliphatic and Aromatic Isocyanates:
Lithium salicylate is employed as a trimer catalyst for aliphatic and aromatic isocyanates, improving the synthesis and production of various chemical compounds.

Sources

https://www.redorbit.com/news/health/1113093183/biploar-disorder-lithium-therapy-sodium-based-better-031214/ https://www.theguardian.com/society/2016/aug/14/lithium-should-be-more-widely-used-for-bipolar-disorder-researchers-say https://www.sdrugs.com/?c=drug&s=lithium%20salicylate Junquera, E.; Pena, L.; Aicart, E., Binding of sodium salicylate by beta-cyclodextrin or 2,6-di-O-methyl-beta-cyclodextrin in aqueous solution. J. Pharm. Sci. 1998, 87, 86-90. Herbert, P. R.; Joseph, H. J., Chemiluminescent system catalysts. United Sates Patent 4626383 1986. W.E., S.; H.T., K.; T., H., Trimer catalyst for aliphatic and aromatic isocyanates. United Sates Patent 5905151 1999.

Flammability and Explosibility

Notclassified

Purification Methods

Recrystallise it from EtOH (2mL/g) by partial evaporation. [Beilstein 10 H 59, 10 II 32, 10 III 93, 10 IV 126.]

InChI:InChI=1/C7H6O3.Li/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

Upstream product

• 69-72-7 salicylic acid 

Downstream Products

• 108-95-2 phenol 
• 1337555-02-8 Co^II(OH)(salicylate)(H₂O) 
• 147-85-3 L-proline 

Relevant articles and documents

New MALDI matrices based on lithium salts for the analysis of hydrocarbons and wax esters

Lithium salts of organic aromatic acids (lithium benzoate, lithium salicylate, lithium vanillate, lithium 2,5-dimethoxybenzoate, lithium 2,5-dihydroxyterephthalate, lithium α-cyano-4-hydroxycinnamate and lithium sinapate) were synthesized and tested as potential matrices for the matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry analysis of hydrocarbons and wax esters. The analytes were desorbed using nitrogen laser (337.1 nm) and ionized via the attachment of a lithium cation, yielding [M + Li]+ adducts. The sample preparation and the experimental conditions were optimized for each matrix using stearyl behenate and n-triacontane standards. The performance of the new matrices in terms of signal intensity and reproducibility, the mass range occupied by matrix ions and the laser power threshold were studied and compared with a previously recommended lithium 2,5-dihydroxybenzoate matrix (LiDHB) (Cvac?ka and Svatos?, Rapid Commun. Mass Spectrom. 2003, 17, 2203). Several of the new matrices performed better than LiDHB. Lithium vanillate offered a 2-3 times and 7-9 times higher signal for wax esters and hydrocarbons, respectively. Also, the signal reproducibility improved substantially, making this matrix a suitable candidate for imaging applications. In addition, the diffuse reflectance spectra and solubility of the synthesized compounds were investigated and discussed with respect to the compound's ability to serve as MALDI matrices. The applicability of selected matrices was tested on natural samples of wax esters and hydrocarbons. Copyright 2014 John Wiley & Sons, Ltd. Copyright