552301-45-8

Basic information

• Product Name: 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid
• Synonyms: 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid
• CAS NO: 552301-45-8
• Molecular Formula: C12H16O3
• Molecular Weight: 208.25364
• Mol File: 552301-45-8.mol

Chemical Properties

• Boiling Point: 362.2±22.0 °C(Predicted)
• Appearance: /
• Density: 1.150±0.06 g/cm3(Predicted)
• PKA: 4.42±0.10(Predicted)
• CAS DataBase Reference: 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid(552301-45-8)
• EPA Substance Registry System: 2-(4-(2-hydroxyethyl)phenyl)-2-Methylpropanoic acid(552301-45-8)

Safety Data

• Hazardous Substances Data: 552301-45-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ibuproxam is used as an analgesic for the relief of mild to moderate pain, such as headaches, muscle aches, dental pain, and menstrual cramps. Its pain-relieving properties make it a suitable option for individuals seeking relief from various types of discomfort.
Ibuproxam is also used as an anti-inflammatory agent to reduce inflammation and swelling associated with conditions like arthritis, sprains, and strains. Its ability to inhibit prostaglandin production helps alleviate the symptoms of these inflammatory conditions.
Furthermore, ibuproxam is used as an antipyretic to reduce fever and lower body temperature in cases of elevated temperature due to illness or infection.
However, it is important to note that the use of ibuproxam may pose risks of gastrointestinal bleeding, kidney problems, and cardiovascular events in some individuals. Therefore, it should only be used under the supervision of a healthcare professional to ensure safe and effective treatment.

Upstream product

• 1039038-05-5 C₁₄H₁₈ClNO 
• 192775-97-6 4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene 
• 4654-39-1 4-bromophenethanol 
• 73899-15-7 1-(t-butyldimethylsilyloxy)-2-(4-bromophenyl)ethane 
• 137756-89-9 4-(2-hydroxy ethyl)phenyl boronic acid 
• 594-58-1 2-chloro-2-methylpropanoic acid 

Downstream Products

• 1181267-31-1 2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid ethyl ester 
• 1000536-33-3 2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid methyl ester 
• 1181267-37-7 2-(4-{2-[4-(1H-benzoimidazol-2-yl)-piperidin-1-yl]-ethyl}phenyl)-2-methyl-propionic acid methyl ester 
• 1181267-38-8 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidine]ethyl]-α,α-dimethylphenylacetic acid methyl ester 

Relevant articles and documents

Preparation method of bilastine intermediate

The invention belongs to the field of medicinal chemistry, and relates to a preparation method of a bilastine intermediate 2-(4-(2-hydroxyethyl) phenyl)-2-methyl propionic acid and derivatives thereof. The 2-(4-(2-hydroxyethyl) phenyl)-2-methyl propionic acid and the derivative thereof are obtained by taking a 4-halogenated phenyl-2-methyl propionic acid derivative as a raw material through the steps of alkylation, hydrolysis, reduction and the like, and the compound can be used for synthesizing bilastine.

Method for preparing Bilastine intermediate

The invention discloses a method for preparing a Bilastine intermediate. A key quaternary carbon unit of Bilastine is constructed by using special activity of ethylene sulfate, so that the consumptionof high-toxicity materials is avoided, the operability is improved, and the industrialized production cost is reduced. Meanwhile, a novel synthesis route is designed through combining unique properties of the intermediate and an original synthesis policy of the Bilastine, two protective agents are simultaneously removed in one step, synthesis steps are reduced, the production cost is reduced, andmeanwhile, an expensive catalyst in the prior art is avoided.

Preparation method of new anti-allergic medicine Bilastine intermediate

The invention discloses a preparation method of a new anti-allergic medicine Bilastine intermediate. Quaternary carbon atoms difficult to construct are constructed by using a mild addition reaction, carboxylic groups are introduced at room temperature by

Bilastine preparation method

The invention discloses a Bilastine preparation method. The Bilastine preparation method includes that 2-nitroaniline which is low in price and easy to obtain is taken as a raw material which is subjected to reduction-n-cyclohexylmaleimide reaction, alkyl