552845-84-8

Basic information

• Product Name: 1-BROMO-2,4-DIMETHOXY-5-(1,3-DIOXOLAN-2-YL)BENZENE
• Synonyms: RARECHEM AL BP 0685;1-BROMO-2,4-DIMETHOXY-5-(1,3-DIOXOLAN-2-YL)BENZENE;2-(5-BROMO-2,4-DIMETHOXY-PHENYL)-[1,3]DIOXOLANE
• CAS NO: 552845-84-8
• Molecular Formula: C₁₁H₁₃BrO₄
• Molecular Weight: 289.12
• Mol File: 552845-84-8.mol

Chemical Properties

• Boiling Point: 353.108°C at 760 mmHg
• Flash Point: 144.036°C
• Appearance: /
• Density: 1.452g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: 1-BROMO-2,4-DIMETHOXY-5-(1,3-DIOXOLAN-2-YL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-2,4-DIMETHOXY-5-(1,3-DIOXOLAN-2-YL)BENZENE(552845-84-8)
• EPA Substance Registry System: 1-BROMO-2,4-DIMETHOXY-5-(1,3-DIOXOLAN-2-YL)BENZENE(552845-84-8)

Safety Data

• Hazardous Substances Data: 552845-84-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Bromo-2,4-dimethoxy-5-(1,3-dioxolan-2-yl)benzene is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of new medications, particularly those intended to address anxiety and related disorders, due to its mild sedative and anxiolytic effects.
Used in Chemical Industry:
In the chemical industry, 1-Bromo-2,4-dimethoxy-5-(1,3-dioxolan-2-yl)benzene is utilized as a key component in the production of a variety of chemical substances. Its structural features make it a valuable building block for the development of new chemical entities with diverse applications.

InChI:InChI=1/C11H13BrO4/c1-13-9-6-10(14-2)8(12)5-7(9)11-15-3-4-16-11/h5-6,11H,3-4H2,1-2H3

Upstream product

• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 130333-46-9 5-bromo-2, 4-dimethoxybenzaldehyde 
• 107-21-1 ethylene glycol 

Downstream Products

• 552845-85-9 2-(5-[1,3]dioxolan-2-yl-2,4-dimethoxy-phenyl)-4,4,5,5-tetra-methyl-[1,3,2]dioxaborolane 
• 930601-46-0 2-(5-[1,3]dioxolan-2-yl-2,4-dimethoxy-phenyl)-thiazole 
• 552846-02-3 5-(1H-indol-2-yl)-2,4-dimethoxybenzaldehyde 
• 930601-47-1 N-[2-(5-formyl-2,4-dimethoxyphenylethynyl)phenyl]-2,2-dimethylpropionamide 
• 809240-72-0 5-(2-aminophenylethynyl)-2,4-dimethoxybenzaldehyde 
• 121177-67-1 5-iodo-2,4-dimethoxybenzaldehyde 
• 552845-97-3 2,4-dimethoxy-5-thiazol-2-yl-benzaldehyde 

Relevant articles and documents

Dicarbaporphyrinoid systems. Synthesis of oxo-adj-dibenziphlorins

A series of diformylbenzophenones were generated by sequentially reacting protected bromobenzaldehydes with n-butyllithium and ethyl N,N- dimethylcarbamate. The acetal protective groups were cleaved with refluxing formic acid. Vilsmeier-Haack formylation of 2,2′,4,4′- tetramethoxybenzophenone also afforded a related dialdehyde. MacDonald "2 + 2" condensation of three benzophenone dialdehydes with a dipyrrylmethane gave oxophlorin analogues constructed from two benzene and two pyrrole rings. The free base oxodibenziphlorins were rather unstable in solution, and in most cases these porphyrinoids were isolated as the corresponding trifluoroacetate salts. The spectroscopic properties of 6-oxo-adj-dibenziphlorins are consistent with a nonaromatic ring system. DFT calculations indicated that the macrocycles considerably diverge from planarity, particularly when methoxy substituents are present on the arene rings.

Carboxylated, heteroaryl-substituted chalcones as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases

Starting from a simple chalcone template, structure-activity relationship (SAR) studies led to a series of carboxylated, heteroaryl-substituted chalcone derivatives as novel, potent inhibitors of vascular cell adhesion molecule-1 (VCAM-1) expression. Corr

PROCESS OF MAKING CHALCOME DERIVATIVES

This invention is a novel methods of manufacturing chalcones that includes reacting a carbon-linked heteroaryl or heterocyclic substituted benzaldehyde with an acetophenone in a solvent or mixture of solvents in the presence of LiOMe. Also provided are new chalcones for the treatment of medical conditions.