55578-79-5

Basic information

• Product Name: 2-(2-FURYL)ANILINE
• Synonyms: AKOS BAR-0082;2-FURAN-2-YL-PHENYLAMINE;2-(2-FURYL)ANILINE;2-Fur-2-ylaniline;2-Fur-2-ylaniline 97%;2-(2-Aminophenyl)furan;2-(Fur-2-yl)aniline97%
• CAS NO: 55578-79-5
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• Mol File: 55578-79-5.mol

Chemical Properties

• Boiling Point: 273.5 °C at 760 mmHg
• Flash Point: 119.2 °C
• Appearance: /
• Density: 1.138 g/cm³
• Vapor Pressure: 0.0057mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 2-(2-FURYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-FURYL)ANILINE(55578-79-5)
• EPA Substance Registry System: 2-(2-FURYL)ANILINE(55578-79-5)

Safety Data

• Hazardous Substances Data: 55578-79-5(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
2-(2-FURYL)ANILINE is used as a versatile building block for the synthesis of various organic compounds due to the presence of both furan and amino groups in its structure. This allows for a broad range of chemical reactions and the creation of diverse products.
Used in Pharmaceutical Industry:
2-(2-FURYL)ANILINE is used as an intermediate in the synthesis of pharmaceuticals, particularly in the production of antimalarial drugs. Its unique chemical properties make it a valuable component in the development of new and effective medications.
Used in Dye Production:
2-(2-FURYL)ANILINE is used as a key component in the production of dyes, where its chemical structure contributes to the color and properties of the final product.
Safety Considerations:

InChI:InChI=1/C10H9NO/c11-9-5-2-1-4-8(9)10-6-3-7-12-10/h1-7H,11H2

Upstream product

• 28988-02-5 2-(2-nitrophenyl)-furan 
• 13331-23-2 fur-2-ylboronic acid 
• 615-36-1 2-bromoaniline 
• 577-19-5 2-nitrophenyl bromide 
• 615-43-0 2-iodophenylamine 
• 118486-94-5 2-(tributylstannyl)furan 
• 29048-34-8 5-(2-nitrophenyl)-2-furoic acid 

Downstream Products

• 102269-45-4 2-[(2-Furan-2-yl-phenylamino)-methylene]-malonic acid diethyl ester 
• 852285-83-7 5-Cyano-furan-2-carboxylic acid (2-furan-2-yl-phenyl)-amide 
• 877231-04-4 4-cyano-N-(2-furan-2-ylphenyl)-3-methyl-benzamide 
• 1182844-54-7 4-phenylfuro[3,2-c]quinoline 
• 1352548-18-5 N-[2-(2-furyl)phenyl]-4-methylbenzenesulfonamide 
• 1359768-78-7 N-allyl-2-(2-furyl)aniline 
• 1359768-85-6 N,N-diallyl-2-(2-furyl)aniline 
• 221230-45-1 2-(2-furyl)-1-ethynylbenzene 
• 221230-61-1 ((2-(furan-2-yl)phenyl)ethynyl)trimethylsilane 
• 400744-13-0 N-(2-(furan-2-yl)phenyl)acetamide 
• 55578-83-1 2-(2-azidophenyl)furan 
• 55077-51-5 4H-furo[3,2-b]indole 

Relevant articles and documents

Gold-Catalyzed Cascade Reactions of 4 H-Furo[3,2-b]indoles with Allenamides: Synthesis of Indolin-3-one Derivatives

Merging the ability of cationic gold(I) catalysts to activate unsaturated π-systems with the electrophiles-driven ring-opening reactions of furans, we describe a new approach to synthesize 2-spiroindolin-3-ones from 4H-furo[3,2-b]indoles. The reaction occ

B2N2-Embedded Polycyclic Aromatic Hydrocarbons with Furan and Thiophene Derivatives Functionalized in Crossed Directions

A series of polycyclic aromatic hydrocarbons (PAHs), consisting of two pairs of BN units, have been designed and their synthesis has been achieved by electrophilic C?H borylation. Two conjugation extension directions can be found in these B2Ns

Rhodium(I)-Catalyzed Aryl C-H Carboxylation of 2-Arylanilines with CO2

An unprecedented Rh(I)-catalyzed, amino-group-assisted C-H carboxylation of 2-arylanilines with CO2 under redox-neutral conditions has been developed. This reaction was promoted by a phosphine ligand with t-BuOK as the base and did not require the use of additional strong organometallic reagent. It enabled an efficient direct conversion of a broad range of 2-(hetero)arylanilines including electron-deficient heteroarenes to various phenanthridinones. Possible intermediates of the reaction were also evaluated in the preliminary mechanistic studies.

TRANSITION METAL COMPOUND, CATALYST FOR OLEFIN MULTIMERIZATION AND METHOD FOR PRODUCING OLEFIN MULTIMER

PROBLEM TO BE SOLVED: To provide a novel transition metal compound, a catalyst for olefin multimerization containing the compound and having excellent activity and selectivity, and a method for producing an olefin multimer that is performed in the presence of the catalyst for olefin multimerization. SOLUTION: The present invention provides a transition metal compound of general formula (1), a catalyst for olefin polymerization containing the same, and a method for producing an olefin polymer with the catalyst (R1-R6 are a hydrogen atom or the like, M is a transition metal atom in the periodic table group 6, n is a valence of M, X is a halogen atom or the like, Y is an oxygen atom or the like, Z is a hydrocarbon group or the like). SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Pd/Cu-Catalyzed aerobic oxidative aromatic C-H bond activation/N-dealkylative carbonylation towards the synthesis of phenanthridinones

It is important to achieve diverse functionalization of tertiary anilines due to their importance in biological molecules, pharmaceutical, functional materials, and ligands. A straightforward Pd/Cu-catalyzed oxidative C-H bond activation/N-dealkylative carbonylation of tertiary [1,1′-biphenyl]-2-anilines towards the synthesis of various biologically important phenanthridin-6(5H)-ones has been developed. A wide range of functional groups are well tolerated in this transformation. Moreover, O2 is utilized as the terminal oxidant to promote the oxidative carbonylation process.

Palladium-Catalyzed Synthesis of Tetrasubstituted Olefins by Triple Domino Process

An efficient, highly regio- and stereoselective protocol for the synthesis of tetrasubstituted olefins was developed to take place by a palladium(0)-catalyzed triple domino process. It involves the formation of three new C?C bonds through double carbopalladation and C?H activation across 2-bromoaryl alkynyl biaryls/heteroaryls with norbornene. This method is practically simple with broad substrate scope and tolerates a wide range of substituents. The products bearing 9H-pyrrolo[1,2-a]indole motifs reveal intriguing solid state fluorescence properties and thus form a new class of aggregation induced emission (AIE) fluorophores. (Figure presented.).

Palladium-Catalyzed C-H Bond Activation by Using Iminoquinone as a Directing Group and an Internal Oxidant or a Co-oxidant: Production of Dihydrophenanthridines, Phenanthridines, and Carbazoles

A palladium-catalyzed C-H bond activation reaction, via a redox-neutral pathway, for the preparation of dihydrophenanthridine, phenanthridine, and carbazole derivatives from biaryl 2-iminoquinones is developed. The preinstalled iminoquinone was designed to act as a directing group for ortho C-H activation and an internal oxidant or a co-oxidant. This catalysis proceeded through the following sequence: C-H bond activation, coordination and insertion of activated olefins, β-hydride elimination, H-shift, insertion, and protonation or β-hydride elimination. In addition, carbazoles can be prepared efficiently by using this method without the addition of external oxidants.

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

A series of N-sulfonyl-aminobiaryl derivatives have been examined as novel antitubulin agents. Compound 21 [N-(4′-cyano-3′-fluoro-biphenyl-2-yl)-4-methoxy-benzenesulfonamide] exhibits remarkable antiproliferative activity against four cancer cell lines (pancreatic AsPC-1, lung A549, liver Hep3B, and prostate PC-3) with a mean GI50 value of 57.5 nM. Additional assays reveal that 21 inhibits not only tubulin polymerization but also the phosphorylation of STAT3 inhibition with an IC50 value of 0.2 μM. Four additional compounds (8, 10, 19, and 35) are also able to inhibit this phosphorylation. This study describes novel N-sulfonyl-aminobiaryl (biaryl-benzenesulfonamides) as potent anticancer agents targeting both STAT3 and tubulin. (Chemical Equation Presented).

Furan ring opening-indole ring closure: Recyclization of 2-(2-aminophenyl)furans into 2-(2-oxoalkyl)indoles

The acid-catalyzed rearrangement of 5-alkyl-2-[2-(sulfonylamino)phenyl] furans into 2-(2-oxoalkyl)indoles is described. When the N-sulfonyl group in the starting compounds was displaced by an N-acyl group, the corresponding indoles were not formed under t

Trifluoroacetic acid-mediated facile construction of 6-substituted phenanthridines

The trifluoroacetic acid-mediated reaction of 2-arylanilines with arylaldehydes has been developed to give a variety of 6-substituted phenanthridines. This is a very simple and convenient one-pot process for library construction.