56456-49-6

Basic information

• Product Name: 4-Chloro-2-fluorobenzyl alcohol
• Synonyms: RARECHEM AL BD 0387;4-CHLORO-2-FLUOROBENZYL ALCOHOL;(4-chloro-2-fluorophenyl)Methanol
• CAS NO: 56456-49-6
• Molecular Formula: C₇H₆ClFO
• Molecular Weight: 160.57
• EINECS: 205-091-2
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Alcohols;Chlorine Compounds;Fluorine Compounds
• Mol File: 56456-49-6.mol

Chemical Properties

• Boiling Point: 227.6°Cat760mmHg
• Flash Point: 91.4°C
• Appearance: /
• Density: 1.344g/cm³
• Vapor Pressure: 0.0434mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.68±0.10(Predicted)
• CAS DataBase Reference: 4-Chloro-2-fluorobenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-fluorobenzyl alcohol(56456-49-6)
• EPA Substance Registry System: 4-Chloro-2-fluorobenzyl alcohol(56456-49-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 56456-49-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2-fluorobenzyl alcohol is used as a synthetic intermediate for the production of various pharmaceutical compounds. Its unique halogenated structure allows for the creation of a wide range of drug molecules, making it a valuable component in the development of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloro-2-fluorobenzyl alcohol is employed as an intermediate in the synthesis of different agrochemical products. Its versatility in chemical reactions enables the production of a variety of compounds used in agriculture, such as pesticides and herbicides, to improve crop protection and yield.
Used in Chemical Synthesis:
4-Chloro-2-fluorobenzyl alcohol is used as a key intermediate in the synthesis of a variety of chemical products. Its reactivity and functional groups make it a suitable candidate for the production of specialty chemicals, which can be utilized in various industries, including plastics, coatings, and materials science.

InChI:InChI=1/C7H6ClFO/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4H2

Upstream product

• 446-30-0 4-chloro-2-fluorobenzoic acid 
• 61072-56-8 4-chloro-2-fluorobenzaldehyde 
• 452-75-5 4-chloro-2-fluorotoluene 
• 148893-72-5 4-chloro-2-fluorobenzoic acid methyl ester 

Downstream Products

• 71916-82-0 1-(bromomethyl)-4-chloro-2-fluorobenzene 
• 536761-10-1 N-(4-chloro-2-fluoro-benzyl)phthalimide 
• 900505-17-1 4-(4-chloro-2-fluoro-benzyl)-3-(4-chloro-phenyl)-7-iodo-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 72235-57-5 (4-chloro-2-fluorophenyl)methanamine 
• 101160-87-6 1-(4-chloro-2-fluorophenyl)-2-<4-(trans-4-pentylcyclohexyl)phenyl>ethane 
• 478373-33-0 {4'-Methoxy-3'-[(4-chloro-2-fluorobenzyloxycarbonylamino)-methyl]biphenyl-3-yl}acetic acid 
• 478373-83-0 2-{4'-Methoxy-3'-[(4-chloro-2-fluorobenzyloxycarbonylamino)methyl]biphenyl-3-yl}propionic acid 
• 478373-53-4 {4'-ethoxy-3'-[(4-chloro-2-fluorobenzyloxycarbonylamino)methyl]biphenyl-3-yl}acetic acid 
• 909186-19-2 (4-chloro-2-fluorobenzyloxy)(tert-butyl)dimethylsilane 
• 87417-71-8 4-chloro-1-(chloromethyl)-2-fluorobenzene 

Relevant articles and documents

TRICYCLIC PIPERIDINE COMPOUNDS

The present invention relates to compounds of the formula (I) wherein R1a, R1b, R2, R3, (R4)n and ring (A) are as described in the description, to their preparation, to pharmaceutically acc

BICYCLIC AZAHETEROCYCLIC COMPOUNDS AS NR2B NMDA RECEPTOR ANTAGONISTS

Disclosed are chemical entities of Formula (I): wherein R1 and Z are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of Formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of Formula (I).

TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE

The present invention relates to compounds of the formula (I), wherein R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to thei

TRICYCLIC PIPERIDINE COMPOUNDS

The present invention relates to compounds of the formula (I), wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

METALLOENZYME INHIBITOR COMPOUNDS

The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity

The disruption of the p53-Hdm2 protein-protein interaction induces cell growth arrest and apoptosis. We have identified the 1,4-benzodiazepine-2,5-dione scaffold as a suitable template for inhibiting this interaction by binding to the Hdm2 protein. Several compounds have been made with improved potency, solubility, and cell-based activities.

AMIDE COMPOUND AND METHOD OF CONTROLLING PLANT DISEASE WITH THE SAME

A amid compound of the formula (1): wherein, in the formula, R51 represents a halogen atom, a C1-C6 alkyl group and the like; R52 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group and the like; R53 represents a halogen atom and the like; R56 represents a halogen atom and the like; R57 represents a hydrogen atom and the like; R58 and R59 independently represent a hydrogen atom, a C1-C3 alkyl group and the like; R60 represents a C1-C4 alkyl group, a C1-C4 haloalkyl group, a C3-C4 alkenyl group, or a C3-C6 alkynyl group; R61 represents a C1-C4 alkyl group, a C1-C4 haloalkyl group, a C3-C4 alkenyl group or a C3-C6 alkynyl group or a C2-C4 cyanoalkyl group; R62, R63 and R64 represent a hydrogen atom, a halogen atom and the like; X represents a oxygen atom or a sulfur atom; has an excellent activity against plant diseases.

Pyrimidin-4-one derivatives, their intermediates for their production and processes for producing these compounds

PCT No. PCT/JP96/02169 Sec. 371 Date Feb. 10, 1998 Sec. 102(e) Date Feb. 10, 1998 PCT Filed Aug. 1, 1996 PCT Pub. No. WO97/06150 PCT Pub. Date Feb. 20, 1997Novel pyrimidin-4-one derivatives of formula [1] are provided, which are useful as active ingredien

The Synthesis and Liquid-Crystal Transition Temperatures of Some Fluoro-Substituted Benzonitriles

Various laterally fluoro-substituted benzonitriles have been prepared containing a trans-4-(n-alkyl)cyclohexane ring linked to the 4-position of the benzonitriles either through a methyleneoxy (-CH2O-) or an ethylene (-CH2CH2-) bridge.The bridging group links the benzonitrile and cyclohexane rings either directly or through an additional 1,4-bonded cyclohexane or benzene ring.The synthesis and liquid-crystal transition temperatures of these new compounds are described.In several cases the nematic-isotropic transition temperatures of F-substituted benzonitriles are found to be higher than those of the non-laterally substituted analogues.