757976-84-4

Upstream product

• 110-86-1 pyridine 
• 501-53-1 benzyl chloroformate 
• 57381-37-0 2-bromo-5-chloro-benzonitrile 
• 766-84-7 3-chloro-benzonitrile 

Downstream Products

• 732275-75-1 tert-butyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate 
• 889101-57-9 4-[2-(1-(acetylamino)vinyl)-4-chlorophenyl]piperidine-1-carboxylic acid tert-butyl ester 
• 455957-92-3 tert-butyl 4-{2-[(1S)-1-(acetylamino)ethyl]-4-chlorophenyl}piperidine-1-carboxylate 
• 757976-86-6 benzyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

An efficient synthesis of a highly functionalized 4-arylpiperidine

In this manuscript, an efficient synthesis of a functionalized 4-arylpiperidine is disclosed. Several synthetic approaches towards formation of the key aryl-piperidine sp3 carbon-carbon bond are discussed, including a scalable route to the piperidine via

Process and intermediates for the preparation of 4-aryl piperidines

A novel process is provided for the preparation of 4-aryl piperidines, and the useful intermediates obtained therein. These compounds are intermediates for the synthesis of melanocortin-4 receptor (MC-4R), which are useful for the treatment of disorders such as obesity, diabetes, male sexual dysfunction, and female sexual dysfunction.