57396-67-5

Basic information

• Product Name: 2-Methoxyphenylhydrazine hydrochloride
• Synonyms: 2-METHOXYPHENYLHYDRAZINE HCL;2-HYDRAZINOANISOLE HYDROCHLORIDE;2-HYDRAZINOPHENYL METHYL ETHER;1-(2-METHOXYPHENYL)HYDRAZINE HYDROCHLORIDE;2-Methoxyphenylhydrazine hydrochloride;Albb-005956;[(2-methoxyphenyl)amino]ammonium chloride;[(2-methoxyphenyl)amino]azanium chloride
• CAS NO: 57396-67-5
• Molecular Formula: C7H11ClN2O
• Molecular Weight: 174.63
• EINECS: 230-199-1
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 57396-67-5.mol

Chemical Properties

• Boiling Point: 296.8°C at 760 mmHg
• Flash Point: 133.3°C
• Appearance: /
• Vapor Pressure: 0.0014mmHg at 25°C
• CAS DataBase Reference: 2-Methoxyphenylhydrazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxyphenylhydrazine hydrochloride(57396-67-5)
• EPA Substance Registry System: 2-Methoxyphenylhydrazine hydrochloride(57396-67-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 57396-67-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxyphenylhydrazine hydrochloride is used as a synthetic building block for the creation of various biologically active compounds, leveraging its chemical properties to contribute to the development of new pharmaceuticals.
Used in Cancer Treatment Research:
2-Methoxyphenylhydrazine hydrochloride is used as a potential therapeutic agent in cancer treatment, given its capacity to be integrated into compounds that target cancer cells, thereby offering a pathway for developing novel anticancer drugs.
Used in Organic Synthesis:
As a precursor in organic synthesis, 2-Methoxyphenylhydrazine hydrochloride is utilized for the preparation of other organic compounds, highlighting its importance in the broader field of chemical research and development.
Used in Research Applications:
2-Methoxyphenylhydrazine hydrochloride is used as a reagent in various research applications, facilitating the exploration of its properties and potential uses in scientific studies, which may lead to advancements in medicine and other industries.

InChI:InChI=1/C8H12N2O.2ClH/c1-11-8-5-3-2-4-7(8)6-10-9;;/h2-5,10H,6,9H2,1H3;2*1H

Upstream product

• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 83430-99-3 2-(3,5-dimethyl-1H-pyrazol-1-yl)phenol 
• 912763-12-3 2-(2-methoxyphenyl)-1-methyl-1H-pyrrole 
• 1567335-34-5 trifluoromethanesulfonic acid 2-(2-methoxyphenyl)-5-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-2H-pyrazol-3-yl ester 
• 1567334-50-2 2-chloro-4-[1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl]-pyridine 
• 1567335-30-1 5-[1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl]-2-methylpyridine 
• 1567334-46-6 2-ethoxy-5-[1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl]pyridine 
• 1567335-26-5 4-[1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl]benzonitrile 
• 1567334-37-5 5-(4-ethoxyphenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole 
• 1567335-33-4 2-(2-methoxyphenyl)-5-(2,2,6,6-tetramethyltetrahydropyran-4-yl)-2,4-dihydropyrazol-3-one 
• 792953-16-3 (5-amino-1-(2-methoxyphenyl)-1H-pyrazole-4-carboxamide) 
• 34158-96-8 1-benzoyl-2-(2-methoxyphenyl)hydrazine 
• 5957-89-1 2-(2-methoxy-phenyl)-pyridine 
• 5958-01-0 3-(2-methoxyphenyl)pyridine 
• 1426534-36-2 C₂₃H₂₂N₂O₂ 

Relevant articles and documents

Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts

The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

Synthesis, in vitro Antimicrobial, and Cytotoxic Activities of New 1,3,4-Oxadiazin-5(6H)-one Derivatives from Dehydroabietic Acid

A series of new 1,3,4-oxadiazin-5(6H)-one derivatives (6a–n) of dehydroabietic acid were designed and synthesized as potential antimicrobial and antitumor agents. Their structures were characterized by IR, 1H NMR, 13C NMR, MS, and elemental analyses. All the title compounds were evaluated for their antimicrobial activity against four bacterial and three fungal strains using the serial dilution method. Among them, compound 6e showed the highest antibacterial activity against Bacillus subtilis with a minimum inhibitory concentration (MIC) value of 1.9 μg/mL. In addition, the in vitro cytotoxic activities of the title compounds were also assayed against three human carcinoma cell lines (MCF-7, SMMC-7721, and HeLa) through the MTT colorimetric method. As a result, compounds 6b, 6g, 6k, and 6m exhibited significant inhibition against at least one cell line with IC50 values below 10 μM. Compound 6m was especially found to be the most potent derivative with IC50 values of 2.26 ± 0.23, 0.97 ± 0.11, and 1.89 ± 0.31 μM against MCF-7, SMMC-7721, and HeLa cells, respectively, comparable to positive control etoposide.

A kind of bearberries acid indole derivatives, preparation method and its use

The invention relates to the field of organic synthesis and medicinal chemistry, in particular to a preparation method of an ursolic acid indole derivative having the cytotoxic activity of human body tumor cells, pharmaceutical composition containing the

Design, synthesis, crystal structures, and insecticidal activities of eight-membered azabridge neonicotinoid analogues

Three series of novel azabridge neonicotinoid analogues were designed and synthesized, which were constructed by starting material A, glutaraldehyde, and primary amine hydrochlorides (aliphatic amines, phenylhydrazines, and anilines). Most of the eight-membered azabridge compounds presented higher insecticidal activities than oxabridged compound B against cowpea aphid (Aphis craccivora) and brown planthopper (Nilaparvata lugens). Compared with imidacloprid, some azabridged compounds exhibited excellent insecticidal activity against brown planthopper. The crystal structures and bioassay indicated that changing bridge atoms from O to N could lead to entirely different conformations, which might be the important influential factor of the bioactivities.

Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid

A series of novel 1H-dibenzo[a,c]carbazole derivatives were synthesized in good yield through reaction of methyl 7-oxo-dehydroabietate with a variety of substituted phenylhydrazines. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, MS spectral studies and elemental analysis. All compounds were investigated for their activity against four bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas fluorescens) and three fungi (Trichophyton rubrum, Candida albicans and Aspergillus niger). Among the compound tested, 6d, 6e, 6f and 6m exhibited pronounced antibacterial activities and 6e and 6m also showed moderate antifungal activities. Particularly, 6d exhibited stronger antibacterial activity against B. subtilis comparable to positive control.