58695-42-4Relevant articles and documents
N-ALKYLATED AMINO ACIDS AND OLIGOPEPTIDES, USES THEREOF AND METHODS FOR PROVIDING THEM.
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Page/Page column 17-19; 26; 28-31; 45; 46, (2018/10/25)
The invention relates to the synthesis of amphiphilic amino acid derivatives, in particular to a method for the N-alkylation of an unprotected amino acid or the N-terminus of an oligopeptide substrate, comprising reacting said unprotected amino acid or oligopeptide substrate with an alcohol, e.g. a fatty alcohol, in the presence of a homogeneous transition metal catalyst.
Preparation of N-Boc N-alkyl glycines for peptoid synthesis
Mouna,Nguyen,Rage,Xie,Nee,Mazaleyrat,Wakselman
, p. 2429 - 2435 (2007/10/02)
A series of N-tert-butoxycarbonylated N-allyl, N-propargyl, N-benzyl or branched N-alkyl glycines, useful building blocks for the synthesis of N-alkyl glycine oligomers, have been prepared by N-alkylation of N-Boc glycine or by a two-step method: reductive alkylation and tert-butoxycarbonylation.