59276-79-8

Upstream product

• 1222-98-6 4-nitrochalcone 
• 623-04-1 4-aminobenzenemethanol 
• 98-86-2 acetophenone 
• 98-85-1 1-Phenylethanol 
• 1520-21-4 4-vinyl benzylamine 
• 1074-12-0 phenylglyoxal hydrate 
• 956-05-8 3-(4-aminophenyl)-1-phenyl-2-propen-1-one 
• 556-18-3 4-aminobenzaldehyde 

Downstream Products

• 58122-02-4 3-(4-(dimethylamino)phenyl)-1-phenylpropan-1-one 
• 197915-37-0 6-[2-(4-aminophenyl)ethyl]-3-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-phenyl-5,6-dihydro-pyran-2-one 
• 197915-31-4 6-[2-(4-Amino-phenyl)-ethyl]-3-(2-tert-butyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-phenyl-5,6-dihydro-pyran-2-one 

Relevant academic research and scientific papers

Visible-Light-Promoted Photocatalyst-Free Hydroacylation and Diacylation of Alkenes Tuned by NiCl2·DME

Herein, we describe a visible light-promoted hydroacylation strategy that facilitates the preparation of ketones from alkenes and 4-acyl-1,4-dihydropyridines via an acyl radical addition and hydrogen atom transfer pathway under photocatalyst-free conditions. The efficiency was highlighted by wide substrate scope, good to high yields, successful scale-up experiments, and expedient preparation of highly functionalized ketone derivatives. In addition, this protocol allows for the synthesis of 1,4-dicarbonyl compounds through alkene diacylation in the presence of NiCl2·DME.

Proton-Coupled Electron Transfer: Transition-Metal-Free Selective Reduction of Chalcones and Alkynes Using Xanthate/Formic Acid

Highly chemoselective reduction of α,β-unsaturated ketones to saturated ketones and stereoselective reduction of alkynes to (E)-alkenes has been developed under a transition-metal-free condition using a xanthate/formic acid mixture through proton-coupled electron transfer (PCET). Mechanistic experiments and DFT calculations support the possibility of a concerted proton electron-transfer (CPET) pathway. This Birch-type reduction demonstrates that a small nucleophilic organic molecule can be used as a single electron-transfer (SET) reducing agent with a proper proton source.

Nitrogen-enriched porous carbon supported Pd-nanoparticles as an efficient catalyst for the transfer hydrogenation of alkenes

Ultrafine palladium nanoparticles were immobilized on nitrogen-enriched porous carbon nanosheets (NPC), which were fabricated with g-C3N4 as a nitrogen source and a self-sacrificial template. The prepared Pd@NPC exhibited superior catalytic activity and chemoselectivity for the catalytic transfer hydrogenation of alkenes under mild conditions with formic acid as a hydrogen donor. Moreover, the catalyst displays high structure stability, and can be reused for five runs without any significant decrease of its catalytic activity and obvious leaching of Pd species. This work provides a facile and feasible approach to fabricate nitrogen-enriched carbon nanosheets and to construct advanced Pd supported heterogeneous catalysts for achieving high catalytic activity.

Iridium(III)- benzoxazolyl and benzothiazolyl phosphine ligands catalyzed versatile alkylation reactions with alcohols and the synthesis of quinolines and indole

A series of benzoxazolyl and benzothiazolyl phosphine ligands 4a-4g were synthesized and characterized, which prepared from commercially available 2-aminophenol/2-aminobenzenethiol and 2-bromobenzaldehyde via cyclization and phosphination. The representative ligands 4c and 4e were determined by single-crystal X-ray diffraction. The corresponding iridium complexes could be generated in situ when [Cp*IrCl2]2 (Cp* = pentamethylcyclopentadienyl) encountered ligands. The molecular structures of complexes 5c and 5e were crystallographically characterized. The dihedral angles of N (1)-C (1)-C (8)-C (9) showed an increasing twist compared with the corresponding ligand. The iridium (III) catalysts were screened, [Cp*IrCl2]2/4a proved to be the optimal catalyst, which exhibited efficient catalytic activity toward versatile alkylations including ketones, secondary alcohols and amines with primary alcohols. Additionally, the synthesis of quinolines from ketones with 2-aminobenzyl alcohol by intermolecular cyclization and indole from 2-(2-aminophenyl)ethanol by intramolecular cyclization were achieved under the optimized conditions.

Catalytic asymmetric hydrogenation using a [2.2]paracyclophane based chiral 1,2,3-triazol-5-ylidene-Pd complex under ambient conditions and 1 atmosphere of H2

Chiral 1,2,3-triazol-5-ylidene-Pd complexes with the planar chiral [2.2]paracyclophane wing tip group have been synthesized and structurally characterized. The complex with a labile acetonitrile co-ligand is an excellent catalyst for chemoselective hydrogenation of alkynes and alkenes and enantioselective hydrogenation of prochiral alkenes at ambient conditions and 1.0 atmosphere of H2.

Iron and palladium(II) phthalocyanines as recyclable catalysts for reduction of nitroarenes

Iron(II) and palladium(II) phthalocyanines have been established as recyclable heterogeneous catalysts for the reduction of aromatic nitro compounds to corresponding amines using diphenylsilane/sodium borohydride as hydrogen sources in ethanol. Various reducible functional groups, such as acetyl, ester, cyano, amide, sulphonamide and carboxylic acid etc. were well tolerated, and the methods were applicable up to gram scale. Mechanistic studies showed that reduction of nitro group proceed through direct (nitroso) pathway and possibly iron or palladium phthalocyanines activates nitro group for reduction. FePc and PdPc also catalyzed the generation of hydrogen from the combination of diphenylsilane/sodium borohydride and ethanol.

Novel palladium-on-carbon/diphenyl sulfide complex for chemoselective hydrogenation: Preparation, characterization, and application

A diphenyl sulfide immobilized on palladium-on-carbon system, Pd/C[Ph 2S], was developed to achieve the highly chemoselective hydrogenation of alkenes, acetylenes, azides, and nitro groups in the presence of aromatic ketones, halides, benzyl esters, and N-Cbz protective groups. Instrumental analyses of the heterogeneous catalyst demonstrated that diphenylsul fide was embedded on Pd/C via coordination of its sulfur atom to palladium metal or physical interaction with graphite layers of the activated carbon. The catalyst could be recovered and reused at least five times without any significant loss of the reactivity.

Hydrogenation of Conjugated Olefins by Dichlorobis(benzylcyano)palladium(II)

A homogeneous solution of trans-dichlorobis(benzylcyano)palladium(II) in benzene has been used for the hydrogenation of conjugated double bonds and nitro groups at room temperature and atmospheric pressure.Isomerization of exocyclic double bond in β-pinene to endocyclic double bond to afford α-pinene is also catalysed.