956-05-8Relevant academic research and scientific papers
Antimicrobial, structure-activity relationship and computational studies of some synthesized chalcone derivatives
Badal, Md Mizanur Rahman,Islam, Md Tarikul,Parvin, Reshma,Morol, Md Abul Khaer,Maniruzzaman, Md,Yousuf, Mohammad Abu,Halim, Md Ershad
, p. 644 - 650 (2021/02/27)
Several chalcones viz. 1,3-diaryl-2-propane-1-one (1a), 3-(4-hydroxy phenyl)-1-phenyl-2-propane-1-one (1b), 3-(4-amino-phenyl)-1-phenyl-2-propane-1-one (1c) and their derivatives 2-ethoxy-4,6-diphenyl-4H-pyran-3-carboxylic acid ethyl ester (2a), 4-(4-hydr
Proton-Coupled Electron Transfer: Transition-Metal-Free Selective Reduction of Chalcones and Alkynes Using Xanthate/Formic Acid
Prasanna, Ramanathan,Guha, Somraj,Sekar, Govindasamy
supporting information, p. 2650 - 2653 (2019/04/17)
Highly chemoselective reduction of α,β-unsaturated ketones to saturated ketones and stereoselective reduction of alkynes to (E)-alkenes has been developed under a transition-metal-free condition using a xanthate/formic acid mixture through proton-coupled electron transfer (PCET). Mechanistic experiments and DFT calculations support the possibility of a concerted proton electron-transfer (CPET) pathway. This Birch-type reduction demonstrates that a small nucleophilic organic molecule can be used as a single electron-transfer (SET) reducing agent with a proper proton source.
Mechanochemical catalytic transfer hydrogenation of aromatic nitro derivatives
Portada, Tomislav,Margeti?, Davor,?trukil, Vjekoslav
supporting information, (2018/12/11)
Mechanochemical ball milling catalytic transfer hydrogenation (CTH) of aromatic nitro compounds using readily available and cheap ammonium formate as the hydrogen source is demonstrated as a simple, facile and clean approach for the synthesis of substituted anilines and selected pharmaceutically relevant compounds. The scope of mechanochemical CTH is broad, as the reduction conditions tolerate various functionalities, for example nitro, amino, hydroxy, carbonyl, amide, urea, amino acid and heterocyclic. The presented methodology was also successfully integrated with other types of chemical reactions previously carried out mechanochemically, such as amide bond formation by coupling amines with acyl chlorides or anhydrides and click-type coupling reactions between amines and iso(thio)cyanates. In this way, we showed that active pharmaceutical ingredients Procainamide and Paracetamol could be synthesized from the respective nitro-precursors on milligram and gram scale in excellent isolated yields.
Cobalt-based nanoparticles prepared from MOF-carbon templates as efficient hydrogenation catalysts
Murugesan, Kathiravan,Senthamarai, Thirusangumurugan,Sohail, Manzar,Alshammari, Ahmad S.,Pohl, Marga-Martina,Beller, Matthias,Jagadeesh, Rajenahally V.
, p. 8553 - 8560 (2018/11/30)
The development of efficient and selective nanostructured catalysts for industrially relevant hydrogenation reactions continues to be an actual goal of chemical research. In particular, the hydrogenation of nitriles and nitroarenes is of importance for the production of primary amines, which constitute essential feedstocks and key intermediates for advanced chemicals, life science molecules and materials. Herein, we report the preparation of graphene shell encapsulated Co3O4- and Co-nanoparticles supported on carbon by the template synthesis of cobalt-terephthalic acid MOF on carbon and subsequent pyrolysis. The resulting nanoparticles create stable and reusable catalysts for selective hydrogenation of functionalized and structurally diverse aromatic, heterocyclic and aliphatic nitriles, and as well as nitro compounds to primary amines (>65 examples). The synthetic and practical utility of this novel non-noble metal-based hydrogenation protocol is demonstrated by upscaling several reactions to multigram-scale and recycling of the catalyst.
Oxygen surface groups of activated carbon steer the chemoselective hydrogenation of substituted nitroarenes over nickel nanoparticles
Ren, Yujing,Wei, Haisheng,Yin, Guangzhao,Zhang, Leilei,Wang, Aiqin,Zhang, Tao
supporting information, p. 1969 - 1972 (2017/02/15)
Oxygen surface groups of activated carbon, produced by nitric acid treatment, are not only able to prevent Ni particles from sintering but are also able to preferentially interact with the nitro group of substituted nitroarenes. The resulting Ni/ACOX catalyst is highly active and chemoselective for hydrogenation of nitroarenes to produce functionalized anilines and oximes.
Metal-free transfer hydrogenation of nitroarenes in water with vasicine: Revelation of organocatalytic facet of an abundant alkaloid
Sharma, Sushila,Kumar, Manoranjan,Kumar, Vishal,Kumar, Neeraj
, p. 9433 - 9439 (2014/12/11)
Vasicine, an abundantly available quinazoline alkaloid from the leaves of Adhatoda vasica, has been successfully employed for metal- and base-free reduction of nitroarenes to the corresponding anilines in water. The method is chemoselective and tolerates a wide range of reducible functional groups, such as ketones, nitriles, esters, halogens, and heterocyclic rings. Dinitroarenes reduced selectively to the corresponding nitroanilines under the present reaction conditions.
Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors
Sonmez, Fatih,Sevmezler, Sedat,Atahan, Alparslan,Ceylan, Mustafa,Demir, Dudu,Gencer, Nahit,Arslan, Oktay,Kucukislamoglu, Mustafa
, p. 7479 - 7482 (2012/02/04)
A newly series of 4-(phenylurenyl)chalcone (4a-j) and 4′- (phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-l-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity.
