60515-72-2

Basic information

• Product Name: 2-ISOPROPYL-4-NITROPHENOL
• Synonyms: 2-ISOPROPYL-4-NITROPHENOL;4-nitro-2-isopropylphenol
• CAS NO: 60515-72-2
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.19
• Mol File: 60515-72-2.mol

Chemical Properties

• Melting Point: 86 °C
• Boiling Point: 294.3±33.0 °C(Predicted)
• Appearance: /
• Density: 1.209±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 7.62±0.22(Predicted)
• CAS DataBase Reference: 2-ISOPROPYL-4-NITROPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ISOPROPYL-4-NITROPHENOL(60515-72-2)
• EPA Substance Registry System: 2-ISOPROPYL-4-NITROPHENOL(60515-72-2)

Safety Data

• Hazardous Substances Data: 60515-72-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Isopropyl-4-nitrophenol is used as an intermediate in the synthesis of various pharmaceuticals. Its chemical structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Dye Industry:
In the dye industry, 2-Isopropyl-4-nitrophenol serves as an intermediate for the production of dyes. Its chemical properties make it suitable for creating a variety of colorants used in different applications, including textiles and other industrial processes.
Used in Agricultural Chemicals:
2-Isopropyl-4-nitrophenol is also utilized as an intermediate in the synthesis of agricultural chemicals. Its role in this industry is crucial for the development of products that can enhance crop protection and yield.
Used as Antiseptic and Disinfectant:
In some pharmaceutical and personal care products, 2-Isopropyl-4-nitrophenol is used as an antiseptic and disinfectant. Its antimicrobial properties make it effective in killing or inhibiting the growth of microorganisms, thus maintaining hygiene and preventing infections.
Used in Medical and Agricultural Applications:
Due to its potential antimicrobial and antifungal properties, 2-isopropyl-4-nitrophenol is studied for use in medical and agricultural applications. Its ability to combat microbial infections makes it a candidate for further research and development in these fields.
However, it is important to handle 2-Isopropyl-4-nitrophenol with care as it can be toxic if ingested or inhaled and can cause irritation to the skin and eyes. Proper safety measures should be taken during its use to minimize any adverse effects.

Upstream product

• 26455-31-2 1-isopropoxy-4-nitrobenzene 
• 31539-91-0 N-(2-isopropyl-4-nitrophenyl)acetamide 
• 88-69-7 2-(1-methylethyl)phenol 
• 141-78-6 ethyl acetate 
• 643-28-7 2-isopropylaniline 
• 108-10-1 4-methyl-2-pentanone 
• 181294-58-6 N-tert-butyl-β-formyl-β-nitroenamine 
• 34461-00-2 nitromalondialdehyde sodium salt 

Relevant articles and documents

Efficient Approaches for the Synthesis of Diverse α-Diazo Amides

Metal-catalysed carbenoid chemistry can be exploited for the synthesis of diverse ranges of small molecules from α-diazo carbonyl compounds. In this paper, three synthetic approaches to α-diazo amides are described, and their scope and limitations are determined. On the basis of these synthetic studies, recommendations are provided to assist the selection of the most appropriate approach for specific classes of product. The availability of practical and efficient syntheses of diverse α-diazo acetamides is expected to facilitate the discovery of many different classes of bioactive small molecules.

The: Ortho -substituent on 2,4-bis(trifluoromethyl)phenylboronic acid catalyzed dehydrative condensation between carboxylic acids and amines

2,4-Bis(trifluoromethyl)phenylboronic acid is a highly effective catalyst for dehydrative amidation between carboxylic acids and amines. Mechanistic studies suggest that a 2:2 mixed anhydride is expected to be the only active species, and the ortho-substituent of boronic acid plays a key role in preventing the coordination of amines to the boron atom of the active species, thus accelerating the amidation. This catalyst works for α-dipeptide synthesis.

Kinetic Resolution of 2-Substituted Indolines by N-Sulfonylation using an Atropisomeric 4-DMAP-N-oxide Organocatalyst

The first catalytic kinetic resolution by N-sulfonylation is described. 2-Substituted indolines are resolved (s=2.6–19) using an atropisomeric 4-dimethylaminopyridine-N-oxide (4-DMAP-N-oxide) organocatalyst. Use of 2-isopropyl-4-nitrophenylsulfonyl chloride is critical to the stereodiscrimination and enables facile deprotection of the sulfonamide products with thioglycolic acid. A qualitative model that accounts for the stereodiscrimination is proposed.

RXR partial agonist produced by side chain repositioning of alkoxy RXR full agonist retains antitype 2 diabetes activity without the adverse effects

We previously reported RXR partial agonist CBt-PMN (1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid: 5, EC50 = 143 nM, Emax = 75%), which showed a potent glucose-lowering effect without causing serious adverse effects. However, it remains important to elucidate the structural requirements for RXR efficacy and the glucose-lowering effect because RXR-permissive heterodimers such as PPAR/RXR or LXR/RXR are reported to be activated differently depending upon the chemical structure of RXR agonists. In this work, we show that an RXR partial agonist, NEt-4IB (6-[ethyl-(4-isobutoxy-3-isopropylphenyl)amino]pyridine-3-carboxylic acid: 8b, EC50 = 169 nM, Emax = 55%), can be obtained simply by repositioning the side chains (interchanging the isobutoxy and isopropoxy groups) at the hydrophobic moiety of the RXR full agonist NEt-3IB (6-[ethyl-(3-isobutoxy-4-isopropylphenyl)amino]pyridine-3-carboxylic acid: 7b, EC50 = 19 nM). NEt-4IB (8b) showed antitype 2 diabetes activity without the above side effects upon repeated oral administration to mice at 10 mg/kg/day, similarly to 5.

NPY ANTAGONISTS, PREPARATION AND USES

The present invention concerns novel compounds, their preparation and their uses, therapeutic uses in particular. More specifically it concerns derivative compounds having at least two aromatic cycles, their preparation and their uses, in particular in the area of human or animal health. These compounds have an affinity for the biological receptors of neuropeptide Y, NPY, present in the central and peripheral nervous systems. The compounds of the invention are preferably NPY antagonists, and more particularly antagonists of sub-type NPY Y1, and can therefore be used for the therapeutic or prophylactic treatment of any disorder involving NPY. The present invention also concerns pharmaceutical compositions containing said compounds, their preparation and their uses, as well as treatment methods using said compounds.

2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS

The invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. These compounds are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

Diaminopyrimidines as P2X3 and P2X2/3 modulators

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein A, D, E, G, J, X, Y, Z R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.

A convenient method for synthesizing modified 4-nitrophenols

β-Nitroenamine having a formyl group behaves as the synthetic equivalent of unstable nitromalonaldehyde upon treatment with ketones under basic conditions and leads to 2,6-disubstituted 4-nitrophenols. The present method is safer than the conventional one using sodium nitromalonaldehyde and enables the preparation of hitherto unknown nitrophenols.

BENZAMIDINE DERIVATIVES

Benzamidine derivatives of formula (I) or pharmaceutically acceptable salts thereof exhibit excellent inhibitory activity against factor Xa and are useful for treating or preventing blood coagulation disorders: wherein R 1represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group; R 2represents a hydrogen atom, a halogen atom or an alkyl group, R 3represents a hydrogen atom, an optionally substituted alkyl group, an aralkyl group, an optionally substituted alkanoyl group or an optionally substituted alkylsulfonyl group, R 4and R 5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group, and R 6represents a substituted pyrrolidine group or substituted piperidine group.