High Resolution NMR Spectroscopic Studies on the Metabolism and Futile Deacetylation of 4-Hydroxyacetanilide (Paracetamol) in the Rat
Paracetamol (4-hydroxyacetanilide, acetaminophen) was synthesized with the acetyl group labelled with C2H3 (paracetamol-C2H3), and dosed to rats i.p. at 25 mg/kg (N = 5) and 40 mg/kg (N = 3) body weight. Paracet
Nicholls, Andrew W.,Caddick, Stephen,Wilson, Ian D.,Farrant, R. Duncan,Lindos, John C.,Nicholson, Jeremy K.
Transiently altered acetaminophen metabolism after liver transplantation.
BACKGROUND AND OBJECTIVES: Acetaminophen (INN, paracetamol) is metabolized to N-acetyl-p-benzoquinone imine (NAPQI), a hepatotoxic metabolite, predominantly by cytochrome P450 (CYP) 2E1. Alterations in drug metabolism occur after organ transplantation. Th
Park, Jeong M,Lin, Yvonne S,Calamia, Justina C,Thummel, Kenneth E,Slattery, John T,Kalhorn, Thomas F,Carithers Jr., Robert L,Levy, Adam E,Marsh, Christopher L,Hebert, Mary F
Preparation of labeled human drugmetabolites and drug-drug interaction-probes with fungal peroxygenases
Enzymatic conversion of a drug can be an efficient alternative for the preparation of a complex metabolite compared with a multi-step chemical synthesis approach. Limitations exist for chemical methods for direct oxygen incorporation into organic molecule
Poraj-Kobielska, Marzena,Atzrodt, Jens,Holla, Wolfgang,Sandvoss, Martin,Groebe, Glenn,Scheibner, Katrin,Hofrichter, Martin
p. 513 - 519
(2014/03/21)
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