612835-53-7

Basic information

• Product Name: ethyl 5-bromo-2-fluorobenzoate
• Synonyms: ethyl 5-bromo-2-fluorobenzoate
• CAS NO: 612835-53-7
• Molecular Formula: C₉H₈BrFO₂
• Molecular Weight: 247.0610232
• Mol File: 612835-53-7.mol

Chemical Properties

• Boiling Point: 270.7°C at 760 mmHg
• Flash Point: 117.5°C
• Appearance: /
• Density: 1.504g/cm³
• Vapor Pressure: 0.00675mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: ethyl 5-bromo-2-fluorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-bromo-2-fluorobenzoate(612835-53-7)
• EPA Substance Registry System: ethyl 5-bromo-2-fluorobenzoate(612835-53-7)

Safety Data

• Hazardous Substances Data: 612835-53-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8BrFO2/c1-2-13-9(12)7-5-6(10)3-4-8(7)11/h3-5H,2H2,1H3

Upstream product

• 623-49-4 ethyl cyanoformate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 64-17-5 ethanol 
• 146328-85-0 5-bromo-2-fluoro-benzoic acid 

Downstream Products

• 1206774-43-7 1-(5-bromo-2-fluorophenyl)-1-methylethanol 
• 1333071-87-6 2,3,4,6-tetra-O-acetyl-1-deoxy-1-{3-[1-(4-ethoxyphenyl)-1-methylethyl]-4-fluorophenyl}-β-D-glucopyranose 
• 1318793-75-7 1-deoxy-1-{3-[1-(4-ethoxyphenyl)-1-methylethyl]-4-fluorophenyl}-β-D-glucopyranose 
• 1333071-86-5 C₁₇H₁₈BrFO 

Relevant articles and documents

Practical Continuous-Flow Trapping Metalations of Functionalized Arenes and Heteroarenes Using TMPLi in the Presence of Mg, Zn, Cu, or la Halides

The flow metalation of various arenes and heteroarenes involving an in situ trapping with metal salts (ZnCl2. LiCl, MgCl2, CuCN. LiCl, LaCl3. LiCl) under very convenient conditions (0 ?C, 40 s) is reported. The resulting Mg, Zn, Cu, or La organic species are trapped with various electrophiles in high yields. In several cases, unusual kinetically controlled regioselectivities are obtained. All these flow metalations can be scaled up simply by extending the reaction time and without further optimization. The reaction scope of such flow metalations is considerably broader than that of the corresponding batch procedures.

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