61380-02-7

Basic information

• Product Name: 1-benzyl-4-(methoxymethyl)-N-phenylpiperidin-4-amine
• Synonyms: 1-benzyl-4-(methoxymethyl)-N-phenylpiperidin-4-amine;1-BENZYL-4-(METHOXYMETHYL)-N-PHENYL-4-PIPERIDYLAMINE;4-(Methoxymethyl)-N-phenyl-1-(phenylmethyl)-4-piperidinamine;Einecs 262-746-5;1-Benzyl-4-phenylamino-4-(methoxymethyl)piperidine;4-(MethoxyMethyl)-N-phenyl-1-(benzyl)-4-piperidinaMine;4-(MethoxyMethyl)-N-phenyl-1-(phenylMethyl)-4-piperidinaMine 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• CAS NO: 61380-02-7
• Molecular Formula: C₂₀H₂₆N₂O
• Molecular Weight: 310.43324
• EINECS: 262-746-5
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 61380-02-7.mol

Chemical Properties

• Boiling Point: 432.3°C at 760 mmHg
• Flash Point: 215.2°C
• Appearance: /
• Density: 1.096g/cm³
• Vapor Pressure: 1.12E-07mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 1-benzyl-4-(methoxymethyl)-N-phenylpiperidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(methoxymethyl)-N-phenylpiperidin-4-amine(61380-02-7)
• EPA Substance Registry System: 1-benzyl-4-(methoxymethyl)-N-phenylpiperidin-4-amine(61380-02-7)

Safety Data

• Hazardous Substances Data: 61380-02-7(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

InChI:InChI=1/C20H26N2O/c1-23-17-20(21-19-10-6-3-7-11-19)12-14-22(15-13-20)16-18-8-4-2-5-9-18/h2-11,21H,12-17H2,1H3

Upstream product

• 63260-82-2 ethyl 1-benzyl-4-phenylamino-4-piperidinecarboxylate 
• 85098-64-2 1-benzyl-4-(phenylamino)piperidine-4-carboxylic acid 
• 62-53-3 aniline 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 67-66-3 chloroform 
• 56-37-1 N-benzyl-N,N,N-triethylammonium chloride 
• 61086-04-2 4-(N-phenylamino)-1-phenylmethyl-4-piperidinylmethanol 
• 74-88-4 methyl iodide 

Downstream Products

• 61086-13-3 N-[1-benzyl-4-(methoxymethyl)-4-piperidyl]-N-phenylpropionamide oxalate 
• 61086-12-2 1-benzyl-4-[N-(1-oxopropyl)-N-phenylamino]-4-(methoxymethyl)piperidine 

Relevant articles and documents

SUBSTITUTED N-(2-(AMINO)-2-OXOETHYL)BENZAMIDE INHIBITORS OF AUTOTAXIN AND THEIR PREPARATION AND USE IN THE TREATMENT OF LPA-DEPENDENT OR LPA-MEDIATED DISEASES

The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.

SUBSTITUTED 4-AMINO-PIPERIDINES

The present invention relates to new substituted 4-amino-piperidine opioid receptor modulators, pharmaceutical compositions thereof, and methods of use thereof

A facile method for preparation of [2H3]-sufentanil and its metabolites

An improved process for the synthesis of sufentanil with an overall yield of 26% is described. The reactive and high yielding N-debenzylation of the piperidine intermediate 7 using a mixture of Pd/C and Pd(OH)2 was applied to other drug intermediates affording free amines in short reaction times. The deuterium-labeled sufentanil and the metabolite desmethylsufentanil were synthesized applying the optimized process.

IMPROVED METHOD OF MAKING SUFENTANIL

The present invention relates to a process for the preparation of piperidine derivatives including sufentanil and its pharmaceutically acceptable salts, such as it citrate salt

Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and derivatives thereof

The present invention is directed to a method for preparing a 4-alkoxyalkyl-4-phenylaminopiperidine compound which comprises the steps of (a) reacting an N-substituted-4-piperidone compound with an aniline compound to form a Schiff base compound, (b) reacting the Schiff base compound with an anionic reagent having an anion stabilizing group to form an amine compound, and (c) reducing the amine compound in step (b) with a reducing agent to displace the anion stabilizing group. The anionic reagent in step (b) above has the general formula: wherein X is an anion stabilizing group, Y is hydrogen or lower-alkyl, Z is lower-alkoxy or phenylmethoxy, M is an alkali or alkaline earth metal, and C is a carbon atom.

N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds

Compounds are disclosed of the formula STR1 optically active isomeric forms thereof, and/or pharmaceutically acceptable acid addition salts thereof, in which formula: R is defined in the disclosure.

N-(4-piperidinyl)-N-phenylamides

Novel N-(4-piperidinyl)-N-phenylamides and -carbamates having very potent analgesic activity, methods of preparing same and useful intermediates therefor.

N-(4-piperidinyl)-N-phenylamides and -carbamates

Novel N-(4-piperidinyl)-N-phenylamides and -carbamates having very potent analgesic activity, methods of preparing same and useful intermediates therefor.