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CAS

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6139-38-4

Pyruvaldehyde-bis-thiosemicarbazone, commonly referred to as PBT, is a chemical compound with a diverse range of potential applications, primarily in the medical field. It is recognized for its chelating capabilities, particularly in the treatment of iron overload disorders, and has shown promise in anti-cancer research and as a contrast agent in magnetic resonance imaging (MRI).

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  • 6139-38-4 Structure

  • Basic information

    1. Product Name: PYRUVALDEHYDE-BIS-THIOSEMICARBAZONE
    2. Synonyms: PYRUVALDEHYDE-BIS-THIOSEMICARBAZONE;Hydrazinecarbothioamide, 2,2'-(1-methyl-1,2-ethanediylidene)bis-;Nsc22184
    3. CAS NO:6139-38-4
    4. Molecular Formula: C5H10N6S2
    5. Molecular Weight: 218.3
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 6139-38-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 385.2°C at 760 mmHg
    3. Flash Point: 186.8°C
    4. Appearance: /
    5. Density: 1.53g/cm3
    6. Vapor Pressure: 3.87E-06mmHg at 25°C
    7. Refractive Index: 1.72
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: PYRUVALDEHYDE-BIS-THIOSEMICARBAZONE(CAS DataBase Reference)
    11. NIST Chemistry Reference: PYRUVALDEHYDE-BIS-THIOSEMICARBAZONE(6139-38-4)
    12. EPA Substance Registry System: PYRUVALDEHYDE-BIS-THIOSEMICARBAZONE(6139-38-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 6139-38-4(Hazardous Substances Data)

6139-38-4 Usage

Uses

Used in Iron Overload Disorders Treatment:
PBT is used as a chelating agent for the treatment of iron overload disorders, such as thalassemia and other conditions requiring frequent blood transfusions. It binds and removes excess iron from the body, mitigating the harmful effects of iron accumulation.
Used in Anticancer Applications:
PBT is utilized as an anti-cancer agent, with research indicating its potential to inhibit the growth of certain tumor cells. It achieves this by interfering with the iron metabolism of cancer cells, thereby disrupting their growth and proliferation.
Used in Medical Imaging:
PBT is being investigated for its use as a contrast agent in magnetic resonance imaging (MRI). Its unique properties allow for the enhancement of imaging specific tissues and organs, improving diagnostic accuracy and patient care.

Check Digit Verification of cas no

The CAS Registry Mumber 6139-38-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,3 and 9 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6139-38:
(6*6)+(5*1)+(4*3)+(3*9)+(2*3)+(1*8)=94
94 % 10 = 4
So 6139-38-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H10N6S2/c1-3(9-11-5(7)13)2-8-10-4(6)12/h2H,1H3,(H3,6,10,12)(H3,7,11,13)/b8-2-,9-3-

6139-38-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name [(E)-[(1E)-1-(carbamothioylhydrazinylidene)propan-2-ylidene]amino]thiourea

1.2 Other means of identification

Product number -
Other names STHSEWZEHYXRIB-CPJVMOPCSA

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6139-38-4 SDS

6139-38-4Downstream Products

6139-38-4Relevant articles and documents

Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization

Stefani, Christian,Al-Eisawi, Zaynab,Jansson, Patric J.,Kalinowski, Danuta S.,Richardson, Des R.

, p. 20 - 37 (2015/09/07)

Bis(thiosemicarbazones) and their copper (Cu) complexes possess unique anti-neoplastic properties. However, their mechanism of action remains unclear. We examined the structure-activity relationships of twelve bis(thiosemicarbazones) to elucidate factors

Synthesis and stereostructure of some 5,5′-disubstituted 3-acetyl-2,2′-BI-2H-1,3,4-oxa(thia)diazolines

Somogyi, Laszlo,Czugler, Matyas,Sohar, Pal

, p. 9355 - 9362 (2007/10/02)

The synthesis of some (methyl)glyoxal 1,2-bis(acylhydrazones) (1, 3-6) and their cyclization into the title compounds (7-10) under acetylating conditions are described. The stereostructures of the new biheterocyclic diastereomers were studied by 1/s

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