620939-76-6

Basic information

• Product Name: N-(3-BROMO-2-PYRIDYL)BENZAMIDE
• Synonyms: N-(3-BROMO-2-PYRIDYL)BENZAMIDE;N-(3-BroMopyridin-2-yl)benzaMide
• CAS NO: 620939-76-6
• Molecular Formula: C₁₂H₉BrN₂O
• Molecular Weight: 277.11666
• Mol File: 620939-76-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(3-BROMO-2-PYRIDYL)BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-BROMO-2-PYRIDYL)BENZAMIDE(620939-76-6)
• EPA Substance Registry System: N-(3-BROMO-2-PYRIDYL)BENZAMIDE(620939-76-6)

Safety Data

• Hazardous Substances Data: 620939-76-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-(3-BROMO-2-PYRIDYL)BENZAMIDE is used as a building block for the development of new pharmaceuticals, contributing to the creation of innovative drugs with potential therapeutic benefits.
Used in Agrochemical Industry:
N-(3-BROMO-2-PYRIDYL)BENZAMIDE is used as a building block in the development of agrochemicals, aiding in the production of effective compounds for agricultural applications.
Used in Cancer Therapy Research:
N-(3-BROMO-2-PYRIDYL)BENZAMIDE is used as a potential therapeutic agent in cancer therapy, due to its ability to inhibit certain enzymes and cell signaling pathways that contribute to the growth and progression of cancer.
Used in Organic Synthesis:
N-(3-BROMO-2-PYRIDYL)BENZAMIDE is used as a versatile intermediate in organic synthesis, enabling the creation of a wide range of chemical compounds for various applications.
Used in Heterocyclic Compound Synthesis:
N-(3-BROMO-2-PYRIDYL)BENZAMIDE is used in the synthesis of heterocyclic compounds, which are important in the development of pharmaceuticals, agrochemicals, and other specialty chemicals.

Upstream product

• 13534-99-1 2-Amino-3-bromopyridine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1616976-46-5 N-methyl-N-phenyl-2-[(2-phenyl-1,8-naphthyridin-4-yl)oxy]propanamide 
• 286411-11-8 2-phenyl-1,4-dihydro-1,8-naphthyridin-4-one 
• 52333-44-5 2-phenyl[1,3]oxazolo[4,5-b]pyridine 
• 634202-39-4 N'-(3-hydroxypyridin-2-yl)benzenecarboximidamide 

Relevant articles and documents

Development of N -methyl-(2-arylquinolin-4-yl)oxypropanamides as leads to PET radioligands for translocator protein (18 kDa)

Translocator protein (18 kDa), known as TSPO, is a recognized biomarker of neuroinflammation. Radioligands with PET accurately quantify TSPO in neuroinflammatory conditions. However, the existence of three human TSPO genotypes that show differential affinity to almost all useful TSPO PET radioligands hampers such studies. There is an unmet need for genotype-insensitive, high-affinity, and moderately lipophilic TSPO ligands that may serve as leads for PET radioligand development. To address this need, we varied the known high-affinity TSPO ligand (l)-N,N-diethyl-2-methyl-3-(2- phenylquinolin-4-yl)propanamide in its aryl scaffold, side chain tether, and pendant substituted amido group while retaining an N-methyl group as a site for labeling with carbon-11. From this effort, oxygen-tethered N-methyl- aryloxypropanamides emerged as new high-affinity TSPO ligands with attenuated lipophilicity, including one example with attractive properties for PET radioligand development, namely N-methyl-N-phenyl-2-{[2-(pyridin-2-yl)quinolin- 4-yl]oxy}propanamide (22a; rat Ki = 0.10 nM; human TSPO genotypes Ki = 1.4 nM; clogD = 4.18). This article not subject to U.S. Copyright. Published 2014 by the American Chemical Society.

New access to oxazolopyridines via hydroxyamidine derivatives; application to quinolines

Several 2-aryl and 2-heteroaryloxazolo[4,5-b]pyridines were synthesised in high yields from zwitterion or hydroxyamidine derivatives by heating in dimethylacetamide. These intermediates were generated via hetarynic reaction with the complex base NaNH2-t-BuONa (5:2). The same reactions were possible with quinoline derivatives.