52333-44-5

Upstream product

• 16867-03-1 2-amino-3-hydroxypyridine 
• 100-52-7 benzaldehyde 
• 102-96-5 (2-nitroethenyl)benzene 
• 98-88-4 benzoyl chloride 
• 69634-16-8 N¹-(3-hydroxy-2-pyridyl)benzamide 
• 620939-76-6 N-(3-bromopyridin-2-yl)-2-benzamide 
• 591-50-4 iodobenzene 
• 273-97-2 oxazolo<4,5-b>pyridine 
• 108-86-1 bromobenzene 
• 634202-39-4 N'-(3-hydroxypyridin-2-yl)benzenecarboximidamide 
• 1663-61-2 triethoxymethylbenzene 

Downstream Products

• 144782-70-7 2-Phenyl-oxazolo[4,5-b]pyridine-7-carbaldehyde 
• 134377-80-3 7-butyryl-2-phenyloxazolo<4,5-b>pyridine 
• 144782-78-5 7-benzoyl-2-phenyloxazolo<4,5-b>pyridine 
• 878805-89-1 7-methyl-2-phenyl[1,3]oxazolo[4,5-b]pyridine 
• 134377-79-0 2-phenyl-5-butyryloxazolo[4,5-b]pyridine 
• 144782-71-8 7-Bromo-2-phenyl-oxazolo[4,5-b]pyridine 
• 144782-67-2 2-(2-Phenyl-oxazolo[4,5-b]pyridin-7-yl)-propan-2-ol 
• 144782-66-1 1-(2-Phenyl-oxazolo[4,5-b]pyridin-7-yl)-butan-1-ol 
• 144782-65-0 Phenyl-(2-phenyl-oxazolo[4,5-b]pyridin-7-yl)-methanol 
• 144782-68-3 1-(2-Phenyl-oxazolo[4,5-b]pyridin-7-yl)-cyclohexanol 
• 144782-69-4 2-Phenyl-7-trimethylsilanyl-oxazolo[4,5-b]pyridine 

Relevant academic research and scientific papers

Unprecedentedly mild direct Pd-catalyzed arylation of oxazolo[4,5-b] pyridine

Pd-catalyzed C-2 arylation of oxazolo[4,5-b]pyridine proceeds efficiently at 30°C and tolerates a variety of aryl halides, including derivatized amino acids for which no racemization was observed during the reaction. Experimental evidence for facile depro

Synthesis method of pyridoxazole derivative

The invention provides a synthesis method of a pyridoxazole derivative. The synthesis method comprises the following steps: dissolving 2-amino-3-hydroxypyridine and aldehyde into an organic solvent, carrying out stirring at 70-90 DEG C for 2-3 h, then, ad

Ce(III)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants

An efficient synthesis of a variety of pyridyl benzamides from 2-aminopyridines and nitroolefins is described. This rare-earth-metal-catalyzed reaction provides the corresponding products with broad substrate scope in moderate to excellent yields, in the absence of additives and external oxidants. Water is used as the source of the carbonyl oxygen atom in pyridyl benzamides. Furthermore, 2-substituted oxazolo[4,5-b]pyridines are formed in good yields under the standard conditions when 2-aminopyridin-3-ols are used as the substrates.

Facile Route to 2-Fluoropyridines via 2-Pyridyltrialkylammonium Salts Prepared from Pyridine N-Oxides and Application to 18F-Labeling

Among known precursors for 2-[18F]fluoropyridines, pyridyltrialkylammonium salts have shown excellent reactivity; however, their broader utility has been limited because synthetic methods for their preparation suffer from poor functional group

A green route for the synthesis of 2-substituted benzoxazole derivatives catalyzed by Al3+-exchanged K10 clay

A new, simple, and efficient protocol is developed for the synthesis of 2-substituted benzoxazole derivatives through N-C-O bond formation using Al 3+-exchanged K10 clay (Al3+-K10) as catalyst. A wide range of benzoxazole derivatives

METHODS FOR TREATING SPINAL MUSCULAR ATROPHY

The present invention provides nucleic acid constructs, methods for identifying and validating compounds that increase the inclusion of exon 7 of SMN2 into mRNA transcribed from the SMN2 gene, compounds and pharmaceutical compositions that increase levels of SMN protein produced from the SMN2 gene, and methods for use thereof in treating of SMA.

New access to oxazolopyridines via hydroxyamidine derivatives; application to quinolines

Several 2-aryl and 2-heteroaryloxazolo[4,5-b]pyridines were synthesised in high yields from zwitterion or hydroxyamidine derivatives by heating in dimethylacetamide. These intermediates were generated via hetarynic reaction with the complex base NaNH2-t-BuONa (5:2). The same reactions were possible with quinoline derivatives.

Syntheses of oxazolo[4,5-b]pyridenes and [4,5-d]pyrimidines

Oxazolo[4,5-b]pyridines and [4,5-d]pyrimidines and their 2-substituted compounds have been prepared respectively by condensation of orthoesters of thioimidates derivatives with 2-amino-3-hydroxypyridine and 4-amino-5-hydroxypyrimidine.

Process for the synthesis of oxazolopyridine compounds

Process for the synthesis of compounds of formula (I): STR1 their pyridinium salts and N-oxides, in which formula: the nitrogen of the pyridine ring is situated in the α-, β-, γ- or δ-position with respect to the ring junction; R1 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, substituted or unsubstituted amino, phenyl or cyano group; 0≤m≤2; R2 represents a lower alkyl or cycloalkyl group, a 5- or 6-membered heterocycle containing 1 or 2 hetero atoms, substituted or otherwise, or an aryl group STR2 such that: R3 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, phenyl, substituted or unsubstituted sulfonyl, cyano, thioalkyl, substituted or unsubstituted amino, substituted or unsubstituted sulfinyl, mercapto, hydroxyl or ester group, 0≤n≤5 employing trimethylsilyl polyphosphate (PPSE) as a cyclization agent and enabling the compounds of formula (I) to be obtained in virtually quantitative yields. The compounds of formula I have anti-inflammatory, analgesic, and antipyretic activity.

Synthesis of novel heterocycles: Oxazolo[4,5-b]pyridines and oxazolo[4,5-d]pyrimidines

Novel purine isosters (title compounds) have been prepared by condensation of the appropriate o-hydroxyaminoazine with ethyl orthoformate; extension to other orthoesters and to benzyl thioacetimidate afford 2-alkyl substituted derivatives of these new fus