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6272-55-5

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol, also known as 7-hydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene, is a polycyclic aromatic hydrocarbon (PAH) and a substituted benzopyrene derivative. It is a yellow solid that undergoes activation by hepatic cytosol, leading to the formation of electrophilic sulfuric acid esters. These esters are capable of forming covalent DNA adducts, which can induce mutations.

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  • 6272-55-5 Structure

  • Basic information

    1. Product Name: 7,8,9,10-TETRAHYDRO-BENZO[A]PYREN-7-OL
    2. Synonyms: 7,8,9,10-TETRAHYDRO-BENZO[DEF]CHRYSEN-7-OL;7,8,9,10-tetrahydro-benzo(a)pyren-7-o;7-Hydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene;7,8,9,10-TETRAHYDROBENZO(A)PYREN-7-OL, 9 9%;Benzo[a]pyren-7-ol, 7,8,9,10-tetrahydro-
    3. CAS NO:6272-55-5
    4. Molecular Formula: C20H16O
    5. Molecular Weight: 272.34
    6. EINECS: N/A
    7. Product Categories: Alcohols;C9 to C30;Oxygen Compounds;Building Blocks;C11 to C30+;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
    8. Mol File: 6272-55-5.mol

  • Chemical Properties

    1. Melting Point: 142-144 °C(lit.)
    2. Boiling Point: 508.5°C at 760 mmHg
    3. Flash Point: 189.2°C
    4. Appearance: /
    5. Density: 1.323g/cm3
    6. Vapor Pressure: 3.65E-11mmHg at 25°C
    7. Refractive Index: 1.835
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 14.36±0.20(Predicted)
    11. CAS DataBase Reference: 7,8,9,10-TETRAHYDRO-BENZO[A]PYREN-7-OL(CAS DataBase Reference)
    12. NIST Chemistry Reference: 7,8,9,10-TETRAHYDRO-BENZO[A]PYREN-7-OL(6272-55-5)
    13. EPA Substance Registry System: 7,8,9,10-TETRAHYDRO-BENZO[A]PYREN-7-OL(6272-55-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS: DJ8304000
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 6272-55-5(Hazardous Substances Data)

6272-55-5 Usage

Uses

Used in Research Applications:
7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is used as a research chemical for studying the mechanisms of chemical carcinogenesis and mutagenesis. Its activation by hepatic cytosol and subsequent formation of electrophilic sulfuric acid esters provide insights into the processes that lead to DNA adduct formation and mutations.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 7,8,9,10-tetrahydrobenzo[a]pyren-7-ol is used as a compound for the development of drugs targeting cancer cells. Its ability to form covalent DNA adducts and induce mutations can be exploited in the design of novel therapeutic agents that interfere with cancer cell growth and proliferation.
Used in Environmental Monitoring:
7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is also used in environmental monitoring and assessment, as it is a component of complex mixtures found in polluted environments, such as those contaminated with polycyclic aromatic hydrocarbons (PAHs). Its detection and quantification can help in evaluating the extent of environmental pollution and the potential health risks associated with exposure to PAHs.
Used in Toxicology Studies:
In toxicology, 7,8,9,10-tetrahydrobenzo[a]pyren-7-ol is used as a model compound to study the toxic effects of PAHs on living organisms. Understanding its activation, metabolism, and interaction with biological macromolecules can contribute to the development of strategies for the prevention and treatment of PAH-induced toxicities.

Check Digit Verification of cas no

The CAS Registry Mumber 6272-55-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,7 and 2 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6272-55:
(6*6)+(5*2)+(4*7)+(3*2)+(2*5)+(1*5)=95
95 % 10 = 5
So 6272-55-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H16O/c21-18-6-2-5-15-16-10-9-13-4-1-3-12-7-8-14(11-17(15)18)20(16)19(12)13/h1,3-4,7-11,18,21H,2,5-6H2

6272-55-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 7,8,9,10-tetrahydrobenzo[a]pyren-7-ol

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6272-55-5 SDS

6272-55-5Relevant articles and documents

Dehydrogenation of Nitrogen Heterocycles Using Graphene Oxide as a Versatile Metal-Free Catalyst under Air

Zhang, Jingyu,Chen, Shiya,Chen, Fangfang,Xu, Wensheng,Deng, Guo-Jun,Gong, Hang

, p. 2358 - 2363 (2017/07/22)

Graphene oxide (GO) has been developed as an inexpensive, environmental friendly, metal-free carbocatalyst for the dehydrogenation of nitrogen heterocycles. Valuable compounds, such as quinoline, 3,4-dihydroisoquinoline, quinazoline, and indole derivatives, have been successfully used as substrates. The investigation of various oxygen-containing molecules with different conjugated systems indicated that both the oxygen-containing groups and large π-conjugated system in GO sheets are essential for this reaction. (Figure presented.).

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