62803-47-8

Basic information

• Product Name: 6-Hydroxy-1-indanone
• Synonyms: 6-HYDROXY-1-INDANONE;6-HYDROXY-1-INDANONE 99%;6-Hydrocy-2,3-Dihydro-1H-Inden-1-One;6-Hydroxy-1-Indenone;2,3-Dihydro-6-hydroxy-1H-inden-1-one;6-Hydroxyindan-1-one;6-Hydroxy-2,3-dihydro-1H-inden-1-one;6-hydroxy-2,3-dihydroinden-1-one
• CAS NO: 62803-47-8
• Molecular Formula: C₉H₈O₂
• Molecular Weight: 148.16
• Product Categories: Indanone & Indene;C9;Carbonyl Compounds;Ketones;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 62803-47-8.mol

Chemical Properties

• Melting Point: 154-158 °C(lit.)
• Boiling Point: 329 °C at 760 mmHg
• Flash Point: 139.8 °C
• Appearance: white to light yellow crystal powder
• Density: 1.305 g/cm³
• Vapor Pressure: 9.51E-05mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 9.45±0.20(Predicted)
• CAS DataBase Reference: 6-Hydroxy-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Hydroxy-1-indanone(62803-47-8)
• EPA Substance Registry System: 6-Hydroxy-1-indanone(62803-47-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/38-43
• Safety Statements: 26-36/37
• WGK Germany: 2
• Hazardous Substances Data: 62803-47-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Hydroxy-1-indanone is used as a key intermediate for the synthesis of tetracyclic ketones in the total syntheses of (±)-frondosin C and (±)-8-epi-frondosin C. These compounds have potential applications in the development of new drugs.
Additionally, 6-Hydroxy-1-indanone is used as a precursor in the synthesis of 1,4-dihydroindeno[1,2-c]pyrazoles, which act as potent CHK-1 inhibitors. These inhibitors play a significant role in the development of cancer treatments by inhibiting the growth of cancer cells.

InChI:InChI=1/C9H8O2/c10-7-3-1-6-2-4-9(11)8(6)5-7/h1,3,5,10H,2,4H2

Upstream product

• 13623-25-1 6-methoxy-2,3-dihydro-1H-inden-1-one 
• 69975-65-1 6-aminoindan-1-one 
• 54125-02-9 danishefsky's diene 
• 77970-18-4 3-nitro-2-cyclopentenone 
• 83-33-0 inden-1-one 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 861325-72-6 2,2-dibromo-6-nitro-indan-1-one 
• 1313762-42-3 5-hydroxy-2-vinylbenzaldehyde 
• 2973-80-0 2-bromo-5-hydroxybenzaldehyde 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 15893-42-2 3-(4-methoxyphenyl)propionyl chloride 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 881181-71-1 3-(1-methoxy-4-oxocyclohexa-2,5-dien-1-yl)propanal 

Downstream Products

• 62803-59-2 6-Phenoxy-1-indanon 
• 85515-22-6 6-Hydroxy-7-nitro-indanone 
• 440105-91-9 6-(tert-butyldiphenylsilyloxy)-2,3-dihydroinden-1-one 
• 935248-16-1 6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-one 
• 1056942-40-5 6-[2-chloro-4-(trifluoromethyl)phenoxy]indan-1-one 
• 935248-17-2 6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl-chloride 
• 935248-22-9 3-[3-(2-chloro-ethyl)-indan-5-yloxymethyl]-5-(4-chloro-phenyl)-[1,2,4]oxadiazole 
• 935248-40-1 3-{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-propionaldehyde 
• 935248-21-8 {6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-ethanol 
• 935248-23-0 {6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-propionitrile 
• 935248-20-7 {6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-acetic acid 
• 935248-18-3 2-[{6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-(2-hydroxy-ethyl)-amino]-ethanol 
• 935248-19-4 di-t-butyl {6-[5-(4-chloro-phenyl)-[1,2,4]oxadiazol-3-ylmethoxy]-indan-1-yl}-malonate 
• 440105-76-0 6-[(tert-butyldiphenylsilyl)oxy]-1-indanylamine 

Relevant articles and documents

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