62830-55-1Relevant articles and documents
Transition-Metal-Free Coupling of Polyfluorinated Arenes and Functionalized, Masked Aryl Nucleophiles
Finck, Lucie,Oestreich, Martin
supporting information, p. 11061 - 11064 (2021/06/12)
A chemoselective C(sp2)?C(sp2) coupling of sufficiently electron-deficient fluorinated arenes and functionalized N-aryl-N’-silyldiazenes as masked aryl nucleophiles is reported. The fluoride-promoted transformation involves the in situ generation of the aryl nucleophile decorated with various sensitive functional groups followed by a stepwise nucleophilic aromatic substitution (SNAr). These reactions typically proceed at room temperature within minutes. This catalytic process allows for the functionalization of both coupling partners, furnishing highly fluorinated biaryls in good yields.
Synthesis of novel panchromatic porphyrin-squaraine dye and application towards TiO2 combined photocatalysis
Lee, Se Hoon,Mergu, Naveen,Min, Kyeong Su,Satish Kumar, Rangaraju,Son, Young-A
, (2020/05/13)
Here with, a porphyrin-squaraine-based panchromatic sensitizer was designed, synthesized perfectly and confirmed by its spectral analysis. SP-TBU showed a wide energy absorption in the visible and NIR region, which is very important criteria for photocatalytic activity studies. With this dye, a new TiO2-porphyrin catalyst was prepared and studied using SEM, TEM, UV–vis diffused reflectance spectra, FT-IR spectroscopy, XPS, and EDS analyses. The photocatalytic activity for methylene blue degradation under visible light was studied and compared with the bare TiO2 and (4,4′,4″,4?-(porphine-5,10,15,20-tetrayl)tetrakis(benzoic acid) with TiO2 (TCPP-TiO2) taken with and without the addition of H2O2. The order of the photocatalytic activity performance was TiO2 2 2. The fast and efficient activity of SP-TBU-TiO2 was due to its broad absorption ability. This is the first report of panchromatic TiO2-porphyrin-squarine photocatalysis.
AZEPINO-INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS
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Paragraph 0201, (2020/09/12)
The present invention provides azepino-indoles and other heterocycles and methods of using the compounds for treating brain disorders.
ASYMMETRIC TRIAZOLE BENZAMIDE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME
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Paragraph 676; 677, (2019/06/17)
The present disclosure is directed to asymmetric triazole benzamide compounds of formula (I) and formula (II), pharmaceutical compositions thereof and methods for modulating or activating a Parkin ligase The present disclosure is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase. R1, R2, R3, M1, M2, M3, L1, L2, and L3 are as defined herein.
Regioselective synthesis of indoles via rhodium-catalyzed C-H activation directed by an in-situ generated redox-neutral group
Muralirajan, Krishnamoorthy,Cheng, Chien-Hong
, p. 1571 - 1576 (2014/06/09)
A regioselective synthesis of indoles from arylhydrazine hydrochlorides with alkynes and diethyl ketone catalyzed by a rhodium complex is described. A possible mechanism involving an in-situ generated oxidizing directing group -N-Ni'CR1R2 assisted ortho-C-H activation and reductive elimination are proposed. The catalytic reaction is highly compatible with a wide range of functional arylhydrazines and alkynes. The reaction proceeds under mild reaction conditions and is atom-step economical.
Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping
Sheng, Chunquan,Che, Xiaoying,Wang, Wenya,Wang, Shengzheng,Cao, Yongbing,Yao, Jianzhong,Miao, Zhenyuan,Zhang, Wannian
scheme or table, p. 1706 - 1712 (2011/05/06)
The incidence of invasive fungal infections and associated mortality is increasing dramatically. Although azoles are first-line antifungal agents, cross-resistance and hepatic toxicity are their two major limitations. The discovery of novel non-azole lead compounds will be helpful to overcome these problems. On the basis of our previously reported benzopyran non-azole CYP51 inhibitor, scaffold hopping was used to design structurally diverse new compounds and expand the structure-activity relationships of the lead structure. Five kinds of scaffolds, namely benzimidazole, benzoxazole, benzothiazole, quinazolin-4-one and carboline, were chosen for synthesis. In vitro antifungal activity data and results from molecular docking revealed that the scaffold was important for the antifungal activity. Several compounds showed potent activity against both standard and clinically resistant fungal pathogens, suggesting that they can serve as a good starting point for the discovery of novel antifungal agents.