79271-22-0

Basic information

• Product Name: 4-(4-Iodobenzoyl)morpholine
• Synonyms: 4-(4-Iodobenzoyl)morpholine
• CAS NO: 79271-22-0
• Molecular Weight: 317.126
• Mol File: 79271-22-0.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 4-(4-Iodobenzoyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Iodobenzoyl)morpholine(79271-22-0)
• EPA Substance Registry System: 4-(4-Iodobenzoyl)morpholine(79271-22-0)

Safety Data

• Hazardous Substances Data: 79271-22-0(Hazardous Substances Data)

Upstream product

• 160816-43-3 4-(4-morpholinylcarbonyl)-benzoic acid 
• 1679-64-7 Monomethyl terephthalate 
• 6724-90-9 4-(4-morpholinylcarbonyl)benzoic acid methyl ester 
• 110-91-8 morpholine 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 619-58-9 4-iodobenzoic acid 
• 51207-86-4 (4-amino-phenyl)-morpholin-4-yl-methanone 
• 201230-82-2 carbon monoxide 
• 62830-55-1 2-(4-iodophenyl)hydrazin-1-ium chloride 
• 13329-40-3 4-Iodoacetophenone 
• 624-31-7 4-tolyl iodide 
• 540-37-4 p-aminoiodobenzene 
• 1711-02-0 4-iodobenzoic acid chloride 

Downstream Products

• 389621-84-5 4-(morpholine-4-carbonyl)phenylboronic acid 
• 447455-27-8 morpholino(4-(trifluoromethyl)phenyl)methanone 
• 1427039-13-1 (2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-{[4-(morpholine-4-carbonyl)phenyl]thio}tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1243484-35-6 [4-(2-benzothiazolyl)phenyl]-4-morpholinylmethanone 
• 851895-19-7 morpholin-4-yl-(4-trimethylsilanylethynyl-phenyl)-methanone 

Relevant articles and documents

Palladium-Catalyzed Decarbonylative Iodination of Aryl Carboxylic Acids Enabled by Ligand-Assisted Halide Exchange

We report an efficient and broadly applicable palladium-catalyzed iodination of inexpensive and abundant aryl and vinyl carboxylic acids via in situ activation to the acid chloride and formation of a phosphonium salt. The use of 1-iodobutane as iodide source in combination with a base and a deoxychlorinating reagent gives access to a wide range of aryl and vinyl iodides under Pd/Xantphos catalysis, including complex drug-like scaffolds. Stoichiometric experiments and kinetic analysis suggest a unique mechanism involving C?P reductive elimination to form the Xantphos phosphonium chloride, which subsequently initiates an unusual halogen exchange by outer sphere nucleophilic substitution.

NaI-mediated oxidative amidation of benzyl alcohols/aromatic aldehydes to benzamides via electrochemical reaction

In this research, we have developed a mild electrochemical process for oxidative amidation of benzyl alcohols/aromatic aldehydes with cyclic amines into the corresponding benzamides. This electroorganic synthetic method proceeds using NaI as a redox mediator under ambient temperature in undivided cell, providing more than 25 examples of amide products in moderate to good yields. The benefits of this reaction include one-pot synthesis, open air condition, proceed in aqueous media and no requirement of external conducting salt, base and oxidant.

A general electrochemical strategy for the Sandmeyer reaction

Herein we report a general electrochemical strategy for the Sandmeyer reaction. Using electricity as the driving force, this protocol employs a simple and inexpensive halogen source, such as NBS, CBrCl3, CH2I2, CCl4, LiCl and NaBr for the halogenation of aryl diazonium salts. In addition, we found that these electrochemical reactions could be performed using anilines as the starting material in a one-pot fashion. Furthermore, the practicality of this process was demonstrated in the multigram scale synthesis of aryl halides using highly inexpensive graphite as the electrode. A series of detailed mechanism studies have been performed, including radical clock and radical scavenger study, cyclic voltammetry analysis and in situ electron paramagnetic resonance (EPR) analysis.