- Synthesis and antiviral activity of new phosphonobutoxypurines
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A series of new 9-(4-phosphonobutoxy)purines was synthesized and evaluated as antiviral agents. 9-(4-Phosphonobutoxy)guanine displayed potent and selective activity against HIV-1 in peripheral blood lymphocytes.
- Harnden, Michael R.,Serafinowska, Halina T.
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- Polymer electrolyte membrane based on polyacrylate with phosphonic acid via long alkyl side chains
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A series of novel phosphonated polymers with phosphonic acid groups via different lengths of flexible pendant side chains was synthesized. The radical polymerization of the corresponding diethyl esters of acrylate monomers, followed by hydrolysis with trimethylsilyl bromide produced the expected polyacrylates. Among the three polymers, the cross-linked poly[6-(acryloyloxy) hexylphosphonic acid] (PAHPA) membrane prepared by the recombination of polymer radicals with benzoyl peroxide as a radical initiator showed excellent proton conductivity comparable to that of the Nafion 117 membrane in the range of 30-80% relative humidity (RH) at 80 °C, regardless of the significant low water uptake behavior. Furthermore, well-defined phase separation between the hydrophobic and hydrophilic domains was clearly observed by scanning transmission electron microscopy (STEM) and synchrotron X-ray scattering measurements. To the best of our knowledge, the cross-linked PAHPA membrane shows the best proton conductivity performance among phosphonated polymers already reported. The Royal Society of Chemistry 2013.
- Higashihara, Tomoya,Fukuzaki, Namiko,Tamura, Youko,Rho, Yecheol,Nakabayashi, Kazuhiro,Nakazawa, Satoshi,Murata, Shigeaki,Ree, Moonhor,Ueda, Mitsuru
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- Glucose compound, medicinal composition and application thereof
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The invention discloses a glucose compound, a medicinal composition and application thereof. The glucose compound or pharmaceutically acceptable salt thereof as shown in a formula I almost has no activity of inhibiting cancer cell proliferation in vitro, but has excellent anti-cancer effect and excellent inhibition effect on tumor metastasis in an in-vivo activity test, and has an excellent marketapplication prospect.
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Paragraph 0089; 0167; 0172-0174
(2020/04/06)
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- Compound for immobilizing proteins and method for immobilizing proteins
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A compound for immobilizing proteins and a method for immobilizing the proteins are disclosed. The compound has a structure of formula I, which can covalently immobilize the proteins, especially sjGST-tagged proteins, by means of position selective covalent bonding. In the Formula I, R1 is C1-C12 alkylene, preferably C3-C6 alkylene; R2 is C1-C10 alkyl, preferably C1-C3 alkyl; R3 is H or CH(triplebond)C-(C0-C10) alkyl, preferably CH(triple bond)C-(C0-C2) alkyl, more preferably CH (triple bond) C-.
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Paragraph 0028; 0030-0031
(2019/10/01)
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- Covalent and selective immobilization of GST fusion proteins with fluorophosphonate-based probes
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Using GST fusion protein tags is an attractive approach for protein immobilization. Here we report that pyrimidine-based small-molecule probes with a fluorophosphonate reactive group could specifically react with the tyrosine-111 residue of the Schistosom
- Wang, Xiafeng,Guo, Tianlin,Chen, Jiahui,Li, Xiaofeng,Zhou, Yiqing,Pan, Zhengying
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p. 4661 - 4664
(2018/05/15)
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- NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS
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Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK- activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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Page/Page column 80
(2010/05/14)
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- Guanine, pyrazolo[3,4-d]pyrimidine, and triazolo[4,5-d]pyrimidine (8-azaguanine) phosphonate acyclic derivatives as inhibitors of purine nucleoside phosphorylase
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Phosphonate acyclic derivatives of guanines, pyrazolo[3,4-d]pyrimidines, and triazolo[4,5-d]-pyrimidines (8-azaguanines) are inhibitors of the enzyme purine nucleoside phosphorylase (PNPase) with K′1 values ranging from 0.05 to 1.6 μM. These compounds are enzymatically stable congeners of the potent PNPase inhibitor acyclovir diphosphate (53).
- Beauchamp, Lilia M.,Tuttle, Joel V.,Rodriguez, Martha E.,Sznaidman, Marcos L.
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p. 949 - 956
(2007/10/03)
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- Antiviral phosphonylalkoxy purines
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A compound of formula (I), or a pharmaceutically acceptable salt thereof: STR1 wherein R1 is hydroxy or amino; R2 is hydrogen or amino; R3 is hydrogen, hydroxymethyl or acyloxymethyl; R4 is hydrogen or (when Rs
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