63644-86-0

Basic information

• Product Name: 5-Bromo-4,6-dimethyl-3-pyridinecarbonitrile
• Synonyms: 5-Bromo-4,6-dimethyl-3-pyridinecarbonitrile;5-BroMo-4,6-diMethylnicotinonitrile
• CAS NO: 63644-86-0
• Molecular Formula: C₈H₇BrN₂
• Molecular Weight: 211.05858
• Mol File: 63644-86-0.mol

Chemical Properties

• Boiling Point: 274.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.52±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 0.80±0.28(Predicted)
• CAS DataBase Reference: 5-Bromo-4,6-dimethyl-3-pyridinecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-4,6-dimethyl-3-pyridinecarbonitrile(63644-86-0)
• EPA Substance Registry System: 5-Bromo-4,6-dimethyl-3-pyridinecarbonitrile(63644-86-0)

Safety Data

• Hazardous Substances Data: 63644-86-0(Hazardous Substances Data)

Upstream product

• 42951-71-3 6-chloro-3-bromo-2,4-dimethylpyridine-5-carbonitrile 
• 23819-87-6 5-bromo-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 769-28-8 3-Cyano-4,6-dimethyl-2(1H)-pyridon 

Downstream Products

• 93350-01-7 5-bromo-4,6-dimethylpyridine-3-carboxylic acid 
• 93350-07-3 Methyl 4,6-Dimethyl-5-phenylnicotinate 

Relevant articles and documents

ROR NUCLEAR RECEPTOR MODULATORS

The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological conditions.

A General Synthesis of 5-Arylnicotinates

Arylboronic acids have been found to couple efficiently with 5-bromonicotinates to yield 5-arylnicotinates.The reaction is considerably more sensitive to steric inhibition in the arylboronic acid component than in the pyridyl bromide 4.The dianion salt of the boronic acid is implicated as the reactive intermediate responsible for the facile coupling reaction.Pure arylboronic acids are best prepared by using triisopropyl borate as the transmetalating agent.