637031-88-0

Basic information

• Product Name: 3,3-DIFLUOROCYCLOBUTANOL
• Synonyms: 3,3-DIFLUOROCYCLOBUTANOL;3,3-difluorocyclobutan-1-ol;Cyclobutanol, 3,3-difluoro-;3,3-Difluorocyclobutanol - D11666
• CAS NO: 637031-88-0
• Molecular Formula: C₄H₆F₂O
• Molecular Weight: 108.0866464
• Mol File: 637031-88-0.mol

Chemical Properties

• Boiling Point: 108.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 13.36±0.40(Predicted)
• CAS DataBase Reference: 3,3-DIFLUOROCYCLOBUTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-DIFLUOROCYCLOBUTANOL(637031-88-0)
• EPA Substance Registry System: 3,3-DIFLUOROCYCLOBUTANOL(637031-88-0)

Safety Data

• RIDADR: UN1993
• Hazardous Substances Data: 637031-88-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3,3-Difluorocyclobutanol is used as a starting material for the synthesis of various pharmaceuticals due to its unique chemical structure and reactivity. The presence of fluorine atoms in the molecule enhances its lipophilicity, which can improve the drug's ability to cross cell membranes and increase its bioavailability. Additionally, the cyclobutanol ring provides a versatile scaffold for further chemical modifications, allowing the development of a wide range of therapeutic agents.
Used in Anticancer Applications:
In the field of oncology, 3,3-difluorocyclobutanol is employed as a key intermediate in the development of anticancer drugs. Its unique structure allows for the creation of compounds that can target specific cancer-related pathways, potentially leading to the development of more effective and targeted cancer treatments.
Used in Drug Delivery Systems:
3,3-Difluorocyclobutanol can also be utilized in the design and development of drug delivery systems. Its chemical properties can be exploited to enhance the solubility, stability, and targeted delivery of therapeutic agents, ultimately improving their efficacy and reducing side effects.

InChI:InChI=1S/C4H6F2O/c5-4(6)1-3(7)2-4/h3,7H,1-2H2

Upstream product

• 637031-86-8 (3,3-difluorocyclobutoxymethyl)benzene 

Downstream Products

• 637031-90-4 4-(3,3-difluorocyclobutoxy)-5-methanesulfonyl-2-methylbenzoic acid methyl ester 
• 1618664-00-8 4-(2-chloro-4-(3,3-difluorocyclobutoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide 
• 1273564-99-0 3,3-difluorocyclobutan-1-one 

Relevant articles and documents

Multigram Synthesis of C 4/C5 3,3-Difluorocyclobutyl-Substituted Building Blocks

An approach for the multigram synthesis of 3,3-difluorocyclobutyl-substituted building blocks (including carboxylic acid, amines, alcohols, azide, trifluoroborate ketone) is described. It is shown that, in most cases, ethyl 3,3-difluorocyclobutanecarboxylate is a convenient common synthetic intermediate to obtain the target derivatives. For preparation of 3,3-difluorocyclobutanol or -cyclobutanone, an alternative pathway via reaction of dichloroketene and tert -butyl or benzyl vinyl ether should be applied.

FLUORINATED CYCLOALKYL-DERIVATISED BENZOYLGUANIDINES AND THEIR USE AS A MEDICAMENT

Fluorinated cycloalkyl-derivatised benzoylguanidines of formula (I) are suitable for use as anti-arrhythmic medicaments comprising cardioprotective components for the prophylaxis and treatment of infarcts and also for the treatment of angina pectoris. The