3,3-DIFLUOROCYCLOBUTANOL

Base Information

• Chemical Name: 3,3-DIFLUOROCYCLOBUTANOL
• CAS No.: 637031-88-0
• Molecular Formula: C4H6F2O
• Molecular Weight: 108.088
• Hs Code.: 2906190090
• Mol file: 637031-88-0.mol

Synonyms:3,3-difluorocyclobutanol

Chemical Property of 3,3-DIFLUOROCYCLOBUTANOL

Chemical Property:

• Boiling Point: 108.1±40.0 °C(Predicted)
• PKA: 13.36±0.40(Predicted)
• PSA: 20.23000
• Density: 1.27±0.1 g/cm3(Predicted)
• LogP: 0.77640
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

3,?3-?Difluorocyclobutanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,?3-?Difluorocyclobutanol is a starting material and useful building block of various pharmaceuticals.

Technology Process of 3,3-DIFLUOROCYCLOBUTANOL

There total 2 articles about 3,3-DIFLUOROCYCLOBUTANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3,3-difluorocyclobutoxymethyl)benzene (637031-86-8) → 3,3-difluorocyclobutan-1-ol (637031-88-0)

Guidance literature:

With hydrogen; 10% palladium on activated carbon; In diethyl ether; at 20 ℃; for 5h; under 15001.5 Torr;

Reference yield:

C8H14F2O → 3,3-difluorocyclobutan-1-ol (637031-88-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 60 ℃;

DOI:10.1055/s-0037-1610237

Reference yield: 92.0%

3,3-difluorocyclobutan-1-ol (637031-88-0) + 4-bromo-phenol (106-41-2) → 1-bromo-4-(3,3-difluorocyclobutoxy)benzene

Guidance literature:

3,3-difluorocyclobutan-1-ol; With triphenylphosphine; diethylazodicarboxylate; In toluene; at 0 - 20 ℃; Inert atmosphere;

4-bromo-phenol; In toluene; at 100 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01236

upstream raw materials:

(3,3-difluorocyclobutoxymethyl)benzene

Downstream raw materials:

4-(3,3-difluorocyclobutoxy)-5-methanesulfonyl-2-methylbenzoic acid methyl ester

4-(2-chloro-4-(3,3-difluorocyclobutoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-methylbenzamide

3,3-difluorocyclobutan-1-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 637031-88-0 3,3-DIFLUOROCYCLOBUTANOL

Send

Send

Metric Ton KG G Pound L ML

Send

Send