6372-48-1

Basic information

• Product Name: METHYLPHENYLPHOSPHINE, TECH., 90
• Synonyms: METHYLPHENYLPHOSPHINE, TECH., 90;Methyl-phenyl-phosphane;METHYLPHENYLPHOSPHINE, TECH., 90%
• CAS NO: 6372-48-1
• Molecular Formula: C₇H₉P
• Molecular Weight: 124.120121
• Mol File: 6372-48-1.mol

Chemical Properties

• Boiling Point: 59-60 °C/10 mmHg(lit.)
• Appearance: /
• Density: 0.973 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.57(lit.)
• CAS DataBase Reference: METHYLPHENYLPHOSPHINE, TECH., 90(CAS DataBase Reference)
• NIST Chemistry Reference: METHYLPHENYLPHOSPHINE, TECH., 90(6372-48-1)
• EPA Substance Registry System: METHYLPHENYLPHOSPHINE, TECH., 90(6372-48-1)

Safety Data

• Hazard Codes: F,T
• Statements: 17-23/24/25-36/37/38
• Safety Statements: 16-26-36/37/39-45
• RIDADR: 2845
• HazardClass: 4.2
• PackingGroup: I
• Hazardous Substances Data: 6372-48-1(Hazardous Substances Data)

Upstream product

• 6389-79-3 methyl methylphenylphosphinate 
• 638-21-1 phenylphosphane 
• 74-88-4 methyl iodide 
• 69737-69-5 Acetylmethylphenylphosphanoxid 
• 75-09-2 dichloromethane 
• 15968-90-8 Kaliumhydrogenphenylphosphid 
• 113403-92-2 2-phenyl-2-phosphabicyclo<2.2.2>octa-5,7-diene 2-oxide 
• 77-78-1 dimethyl sulfate 
• 2181-42-2 trimethylsulphonium iodide 
• 38327-00-3 lithium methylphenylphosphide 
• 75-16-1 methylmagnesium bromide 
• 1486-28-8 diphenyl(methyl)phosphine 
• 113403-90-0 2-syn-phenyl-2-oxo-2-phosphabicyclo<2.2.2>oct-5-ene-7,8-dicarboxylic acid 
• 69737-67-3 Acetylmethylphenylphosphan 

Downstream Products

• 66830-55-5 Dimethylaminomethyl-methylphenylphosphin 
• 4271-13-0 methylphenylphosphinic acid 
• 78731-62-1 (Ethoxy-phenyl-methyl)-methyl-phenyl-phosphane 
• 78731-63-2 (Butoxy-phenyl-methyl)-methyl-phenyl-phosphane 
• 122555-33-3 (2-butenyl)methylphenylphosphine 
• 110410-44-1 N-Methyl-1-(methyl-phenylphosphino)thioformamid 
• 139936-87-1 4-(Methyl-phenyl-phosphanyl)-butyronitrile 
• 76645-87-9 2-{[(Methyl-phenyl-phosphanyl)-methyl]-amino}-propionic acid 
• 15849-84-0 ethylmethylphenylphosphine 
• 92752-28-8 (S)-3-Hydroxy-2-{[(methyl-phenyl-phosphanyl)-methyl]-amino}-propionic acid 
• 23808-01-7 1,2-bis(methylphenylphosphino)ethane 
• 153802-43-8 <2-(diphenylphosphino)phenyl>methylphenylphosphine 
• 19315-13-0 methyl(phenyl)phosphineoxide 
• 103411-48-9 RS(P)-2,11-diphenyl-5,8-diaza-2,11-diphosphadodecane 

Relevant articles and documents

Compound containing phosphine chiral center, organic transition metal complex and preparation method thereof

The invention provides a compound containing a phosphine chiral center, an organic transition metal complex and a preparation method thereof. The preparation method of the compound comprises the following steps: (1) reducing a secondary phosphine oxide 1 into a product secondary phosphine hydrogen 2 by using a reducing agent, wherein the reaction temperature is 20 to 100 DEG C, and the reaction time is 12 to 120 hours; and (2) adding alkyne and the secondary phosphine hydrogen prepared in the step (1) into an organic solvent by using a metal catalyst and a chiral ligand as catalysts to obtain the chiral phosphine compound. The synthesized chiral phosphine compound can be used as a ligand to directly react with transition metal salt to synthesize various organic transition metal complexes. According to the synthesis method disclosed by the invention, secondary phosphine oxide with good stability and low odor is used as a raw material, so that direct use of secondary phosphine with high toxicity and odor for reaction is avoided, and the chiral trivalent phosphine product and the derivative thereof are efficiently and selectively obtained.

Ni-Catalyzed Asymmetric Hydrophosphination of Unactivated Alkynes

The practical synthesis of P-stereogenic tertiary phosphines, which have wide applications in asymmetric catalysis, materials, and pharmaceutical chemistry, represents a significant challenge. A regio- and enantioselective hydrophosphination using cheap a

Simple unprecedented conversion of phosphine oxides and sulfides to phosphine boranes using sodium borohydride

A variety of phosphine oxides and sulfides can be efficiently converted directly to the corresponding phosphine boranes using oxalyl chloride followed by sodium borohydride. Optically active P-stereogenic phosphine oxides can be converted stereospecifically to phosphine boranes with inversion of configuration by treatment with Meerwein's salt followed by sodium borohydride.

P-stereogenic ferrocene-based (Trifluoromethyl)phosphanes: Synthesis, structure, coordination properties and catalysis

Diastereoselective ortho-hydroxymethylation of (R)-(1-ferrocenylethyl) dimethylamine and Bronsted-acid-mediatednucleophilic substitution with phenyl(trifluoromethyl)phosphane affords an epimeric mixture of P-stereogenic amine-phosphanes 4a and 4b, which a

Reduction of phosphinites, phosphinates, and related species with DIBAL-H

Diisobutylaluminium hydride has been found to be an excellent reducing agent for phosphinites, phosphinates, and chlorophosphines. By performing reductions in situ, direct synthesis of secondary phosphine boranes from Grignard reagents has been achieved without isolation or purification of any intermediates. Georg Thieme Verlag Stuttgart.

PHOSPHINE TRANSITION METAL COMPLEX, PROCESS FOR PRODUCING THE SAME AND ANTICANCER DRUG CONTAINING THE SAME

There is provided a novel transition metal phosphine complex having excellent anticancer activity. The transition metal phosphine complex is represented by general formula (1): (wherein R1s and R3s each represent an alkyl group, a cy

High atom-economical one-pot synthesis of secondary phosphines and their borane complexes using recycling phosphorus donor reagent

A general new method for the one-pot preparation of secondary phosphines 11 and in situ generation of their borane complexes 12 is described. This method consists of the sequential addition, at room temperature, of equivalent amounts of R1MgBr and R2MgBr to 1 equiv of the phosphorus atom donor reagent 1. Final treatment with water gives secondary phosphines R 1R2PH (or the corresponding phosphine-borane complexes if treated with BH3·THF) and the end product 6, which can be recycled.

Resolution of secondary phosphanes chiral at phosphorus by means of palladium metallacycles

The synthesis of new epimeric compounds [PdCl(C-N){(±)-PHPhR}] (C-N = (R)-C10H6CHMeNH2 and (R)-C6H4CHMeNH2, R = Me and PhCH2) containing chiral secondary phosphanes is reported. Some of these diastereomers can be separated by column chromatography; subsequent re- action of these complexes with 1,2-bis(diphenyiphosphanyl)-ethane (dppe) affords the free phosphanes PHBzPh and PHMePh. The configurational stability of the secondary phosphanes resolved has also been studied.

Processes for producing secondary phosphines

A process for producing a secondary phosphine of formula (2) wherein R1 and R2 may be the same or different and each represent an alkyl group, a cycloalkyl group or an aryl group, each of the above groups being optionally substituted by an alkyl group, an alkoxy group, a halogen atom, a perfluoroalkyl group, an amino group or a phosphino group, which comprises reacting a phosphine halide of formula (1) wherein R1 and R2 are as defined above and X represents a halogen atom, with a metal selected from the metals of Groups 2 to 15 in the Periodic Table or an alloy thereof and reacting the resultant metal di-substituted phosphide with an agent for protonation.

Dimethylsulfonium Methylide as a Methylating Agent for Three-Coordinate Phosphorus Derivatives

Dimethylsulfonium methylide methylates primary alkyl- and arylphosphines and some secondary phosphines containing at least one substituent that does not exhibit donating properties with respect to phosphorus to give corresponding methylphosphines in high yield. The reaction proceeds as a two-step process with initial deprotonation of the phosphine with the ylide and subsequent nucleophilic elimination of the sulfonium salts with the phosphide. The second step determines the overall reaction rate.