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2-Bromo-4-(trifluoromethyl)benzyl bromide is a brominated aromatic compound with the molecular formula C8H5Br2F3. It contains a trifluoromethyl group and is used as a reagent in organic synthesis.
Used in Pharmaceutical Industry:
2-Bromo-4-(trifluoromethyl)benzyl bromide is used as a reagent for the production of various drugs and in the synthesis of other organic compounds. It is known for its ability to react with nucleophiles and has been used in the preparation of benzyl bromides, which are versatile intermediates in organic chemistry.
Used in Organic Synthesis:
2-Bromo-4-(trifluoromethyl)benzyl bromide is used as a reagent in the synthesis of other organic compounds. Its ability to react with nucleophiles makes it a valuable intermediate in organic chemistry.
Safety Precautions:
It is important to handle 2-Bromo-4-(trifluoromethyl)benzyl bromide with caution as it is a hazardous substance that can cause irritation to the skin, eyes, and respiratory system. It should be used in a well-ventilated area and with appropriate protective equipment.

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  • 657-64-7 Structure
  • Basic information

    1. Product Name: 2-Bromo-4-(trifluoromethyl)benzyl bromide
    2. Synonyms: 2-Bromo-4-(trifluoromethyl)benzyl bromide;2-bromo-1-(bromomethyl)-4-(trifluoromethyl)benzene
    3. CAS NO:657-64-7
    4. Molecular Formula: C8H5Br2F3
    5. Molecular Weight: 317.9285096
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 657-64-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 246.5±35.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.885±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Bromo-4-(trifluoromethyl)benzyl bromide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Bromo-4-(trifluoromethyl)benzyl bromide(657-64-7)
    11. EPA Substance Registry System: 2-Bromo-4-(trifluoromethyl)benzyl bromide(657-64-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 657-64-7(Hazardous Substances Data)

657-64-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 657-64-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,5 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 657-64:
(5*6)+(4*5)+(3*7)+(2*6)+(1*4)=87
87 % 10 = 7
So 657-64-7 is a valid CAS Registry Number.

657-64-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Bromo-1-(bromomethyl)-4-(trifluoromethyl)benzene

1.2 Other means of identification

Product number -
Other names 2-bromo-1-bromomethyl-4-trifluoromethyl-benzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:657-64-7 SDS

657-64-7Relevant articles and documents

tBuOK-Promoted Cyclization of Imines with Aryl Halides

Li, Ya-Wei,Zheng, Hong-Xing,Yang, Bo,Shan, Xiang-Huan,Qu, Jian-Ping,Kang, Yan-Biao

, p. 4553 - 4556 (2020/06/08)

A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramolecular coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.

NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS

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Page/Page column 247; 248, (2020/03/05)

The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

NEW HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS

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Page/Page column 64; 186-187; 194; 239-240, (2020/03/05)

The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds, methods of using the compounds and methods of determining the monoacylglycerol lipase (MAGL) inhibitory activity of the compounds.

BIPHENYL DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS

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Page/Page column 20, (2012/12/13)

The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.

PICOLINAMIDO-PROPANOIC ACID DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS

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Page/Page column 39, (2012/12/13)

The present invention is directed to picolanmido-propanoic acid derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.

SUBSTITUTED AMINOTHIAZOLONE INDAZOLES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS

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Page/Page column 155, (2011/06/28)

The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

Pesticidal method using 2-phenylimidazole derivatives

-

, (2008/06/13)

The invention provides a method for the control of arthropod, plant nematode, helminth or protozoan pests using a 2-phenylimidazole derivative of the formula: STR1 wherein R1 represents hydrogen, alkyl (optionally substituted by alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, cyano, carboxy or alkoxycarbonyl), R2 and R3, each represents hydrogen, halogen, nitro, carboxy, cyano, alkoxycarbonyl, alkanoyl, or optionally alkyl substituted carbamoyl or sulphamoyl, or amino (optionally substituted by alkyl, alkoxycarbonyl or alkanoyl) or a group R, RO, RS, RSO or RSO2 in which R represents alkyl (optionally substituted by halogen), and Ar represents a group of the formula: STR2 wherein R4 and R6 each represents halogen or a group R, RO, RS, RSO or RSO2, and R5, R7 and R8 each represents a substituent as defined for R4 and R6, or represents hydrogen, hydroxy, carboxy, nitro, cyano, amino, alkylamino (optionally substituted by alkyl, alkoxycarbonyl or alkanoyl), alkoxycarbonyl or alkanoyl or a pesticidally acceptable salt thereof, with the exclusion of compounds in which R2 and R3 simultaneously represent hydrogen atoms, compositions for use in the method and novel compounds of formula I.

σπ* orthogonal intramolecular charge-transfer (OICT) excited states and photoreaction mechanism of trifluoromethyl-substituted phenyldisilanes

Kira, Mitsuo,Miyazawa, Takashi,Sugiyama, Hisashi,Yamaguchi, Munehiro,Sakurai, Hideki

, p. 3116 - 3124 (2007/10/02)

Photophysical and photochemical properties of phenyldisilanes having a trifluoromethyl substituent on a benzene ring as one of the most suitable substituents for stabilization of the OICT (σπ* orthogonal intramolecular charge transfer) state were investig

Trifluoromethyl substituted 1-aminoindanes

-

, (2008/06/13)

4(5 or 6 or 7)-Trifluoromethyl-1-aminoindanes, useful as inhibitors of N-methyl transferase.

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