663619-90-7 Usage
Uses
Used in Pharmaceutical Research:
4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methylis used as a research compound for the development of new drugs in the pharmaceutical industry. Its unique structure and potential biological activity make it a promising candidate for further investigation and exploration of its therapeutic properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methylis utilized as a starting material or a building block for the synthesis of more complex molecules with potential therapeutic applications. Its chemical properties and functional groups can be further modified to optimize its pharmacological profile and enhance its efficacy as a drug candidate.
Used in Drug Design and Optimization:
4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methylis employed in drug design and optimization processes to identify and develop novel therapeutic agents. Its structural features can be leveraged to create new chemical entities with improved pharmacokinetic and pharmacodynamic properties, leading to the discovery of more effective and safer drugs.
Used in Biological Assays and Screening:
In biological assays and high-throughput screening, 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methylis utilized to evaluate its potential as a bioactive molecule. It can be tested against various biological targets and disease models to assess its efficacy, selectivity, and safety, providing valuable insights for further optimization and development as a drug candidate.
Check Digit Verification of cas no
The CAS Registry Mumber 663619-90-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,6,3,6,1 and 9 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 663619-90:
(8*6)+(7*6)+(6*3)+(5*6)+(4*1)+(3*9)+(2*9)+(1*0)=187
187 % 10 = 7
So 663619-90-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H7BrN2O2/c1-5-2-6(10)9-11-7(13)3-8(14)12(9)4-5/h2-4,13H,1H3
663619-90-7Relevant articles and documents
Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: Synthesis, biological evaluation and molecular modelling
Marshall, Andrew J.,Lill, Claire L.,Chao, Mindy,Kolekar, Sharada V.,Lee, Woo-Jeong,Marshall, Elaine S.,Baguley, Bruce C.,Shepherd, Peter R.,Denny, William A.,Flanagan, Jack U.,Rewcastle, Gordon W.
supporting information, p. 3796 - 3808 (2015/07/27)
A novel series of TGX-221 analogues was prepared and tested for their potency against the p110α, p110β, and p110δ isoforms of the PI3K enzyme, and in two cellular assays. The biological results were interpreted in terms of a p110β comparative model, in order to account for their selectivity towards this isoform. A CH2NH type linker is proposed to allow binding into the specificity pocket proposed to accommodate the high p110β-selectivity of TGX-221, although there was limited steric tolerance for substituents on the pendant ring with the 2-position most favourable for substitution.
