66648-29-1Relevant articles and documents
Cyclohexane-1,3-diketone compound as well as synthesis method and application thereof
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Paragraph 0032-0037; 0070-0075; 0088-0093; 0106-0111, (2020/06/16)
The invention provides a cyclohexane-1,3-diketone compound of which the structural formula is shown in the specification, wherein the group R1 in the structural formula I is -CH3, -CH2CH3, -(CH2)2CH3,-CH(CH3)2, -(CH2)3CH3, -CH(CH3)C2H5, -CH2CH(CH3)2 or -C
NEW CRTH2 ANTAGONISTS
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Page/Page column 73, (2013/03/26)
The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.
New CRTh2 antagonists.
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Paragraph 0155, (2013/03/26)
The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.
New CRTh2 antagonists
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Paragraph 0200-0203, (2013/03/26)
The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.
NEW CRTh2 ANTAGONISTS
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Page/Page column 52, (2013/03/26)
The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.
Functionalization of carboxylic anhydrides at α-carbon with hypervalent iodine reagents: One-pot conversion of anhydrides to 2-sulfonyloxycarboxylate esters
Goff, Jeffrey M.,Justik, Michael W.,Koser, Gerald F.
, p. 5597 - 5599 (2007/10/03)
The treatment of carboxylic anhydrides with iodine(III) sulfonate reagents at ca. 100°C and esterification of the reaction mixtures with MeOH/TsOH·H2O affords 2-sulfonyloxycarboxylate esters. This is consistent with enolic behavior in the anhyd
Practical and efficient methods for sulfonylation of alcohols using Ts(Ms)Cl/Et3N and catalytic Me3N · HCl as combined base: Promising alternative to traditional pyridine
Yoshida, Yoshihiro,Sakakura, Yoshiko,Aso, Naoya,Okada, Shin,Tanabe, Yoo
, p. 2183 - 2192 (2007/10/03)
Several alcohols were smoothly and practically tosylated by two methods A and B. Method A uses the TsCl/Et3N (1.5 - 2.5 equiv)/cat. Me3N · HCl (0.1 - 1.0 equiv) reagent. Compared with the traditional Py-solvent method, the method A has merits of its much higher reaction rate, operational simplicity, economy in the use of the amine, and circumvention of the undesirable side reaction from R-OTs to R-CL. Method B uses TsCl/KOH [or Ca(OH)2]/cat. Et3N (0.1 equiv)/cat. Me3N · HCl (0.1 equiv) as the reagent, which will be suited for practical and large scale production for primary alcohols. On both methods A and B, a clear joint action of Et3N and Me3N · HCl catalysts was observed. 1H NMR measurements support the proposed mechanism of the catalytic cycle. Related methanesulfonylation using Et3N and cat. Me3N · HCl in toluene solvent also successfully proceeded, wherein the clear joint action was also observed.
