672314-58-8

Basic information

• Product Name: (R)-N-Boc-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine
• Synonyms: (R)-N-Boc-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine;[(1R)-1-[4-[[[(1,1-DiMethylethyl)diMethylsilyl]oxy]Methyl]cyclohexyl]ethyl]carbaMic Acid 1,1-DiMethylethyl Ester;CarbaMic acid, [(1R)-1-[4-(hydroxyMethyl)cyclohexyl]ethyl]-, 1,1-diMethylethyl ester (9CI)
• CAS NO: 672314-58-8
• Molecular Formula: C₂₀H₄₁NO₃Si
• Molecular Weight: 371.62994
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 672314-58-8.mol

Chemical Properties

• Boiling Point: 416.4±18.0 °C(Predicted)
• Appearance: /
• Density: 0.930±0.06 g/cm3(Predicted)
• PKA: 12.50±0.46(Predicted)
• CAS DataBase Reference: (R)-N-Boc-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-Boc-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine(672314-58-8)
• EPA Substance Registry System: (R)-N-Boc-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine(672314-58-8)

Safety Data

• Hazardous Substances Data: 672314-58-8(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

Upstream product

• 672314-45-3 (1R,1'R)-N-[1'-(phenyl)ethyl]-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine 
• 672314-40-8 (R)-N-[(4'-tert-butyldimethylsilyloxymethyl-cyclohexyl)methylidene]-1-phenylethanamine 
• 141836-47-7 4-(((tert-butyldimethylsilyl)oxy)methyl)cyclohexane carbaldehyde 
• 141836-50-2 trans-[4-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohexyl]-methanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 105-08-8 bis-1,4-(hydroxymethyl)cyclohexane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 672314-51-1 (R)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine 

Downstream Products

• 671816-04-9 trans-tert-butyl (R)-1-[4-(pyridin-4-ylcarbamoyl)cyclohexyl]ethylcarbamate 
• 129830-38-2 (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide dihydrochloride 
• 672314-62-4 (R)-N-tert-butyloxycarbonyl-1-[4'-(hydroxymethyl)cyclohexyl]ethan-1-amine 

Relevant articles and documents

Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl) cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters

The influence of stereochemistry and alkyl side chain length on the bioactivity of the Rho kinase inhibitor Y-27632 [(+)-1, R = Me] was examined by the synthesis of (+)- and (-)-1, and two alkyl chain analogs (+)- and (-)-2 (R = n-propyl) and (-)-3 (R = n

1,4-SUBSTITUTED CYCLOHEXANE DERIVATIVES

Allylic compounds represented by the formula (I) are provided, wherein each of R1 to R8, m, n, A and X are as defined in the Specification. These compounds can inhibit Rho kinase, and can find utility in repair of damaged nerves in the central and peripheral nervous system by inducing axon growth and regeneration, and in the treatment by inhibition of Rho kinase in disease states in which Rho kinase is implicated. The compounds are relatively cell permeable and pharmaceutical compositions thereof can promote neurite growth and are also useful for the prevention of cell proliferation in malignant deseases.