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4-FLUOROCYCLOHEXANONE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 68223-64-3 Structure
  • Basic information

    1. Product Name: 4-FLUOROCYCLOHEXANONE
    2. Synonyms: 4-FLUOROCYCLOHEXANONE;4-fluorocyclohexan-1-one;Cyclohexanone, 4-fluoro-
    3. CAS NO:68223-64-3
    4. Molecular Formula: C6H9FO
    5. Molecular Weight: 116.14
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 68223-64-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 164.4±33.0℃ (760 Torr)
    3. Flash Point: 54.2±15.6℃
    4. Appearance: /
    5. Density: 1.03±0.1 g/cm3 (20 ºC 760 Torr)
    6. Vapor Pressure: 1.972mmHg at 25°C
    7. Refractive Index: 1.414
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: 4-FLUOROCYCLOHEXANONE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-FLUOROCYCLOHEXANONE(68223-64-3)
    12. EPA Substance Registry System: 4-FLUOROCYCLOHEXANONE(68223-64-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 68223-64-3(Hazardous Substances Data)

68223-64-3 Usage

Uses

4-Fluorocyclohexanone is a reactant in the synthetic preparation of rapamycin.

Check Digit Verification of cas no

The CAS Registry Mumber 68223-64-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,2,2 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 68223-64:
(7*6)+(6*8)+(5*2)+(4*2)+(3*3)+(2*6)+(1*4)=133
133 % 10 = 3
So 68223-64-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H9FO/c7-5-1-3-6(8)4-2-5/h5H,1-4H2

68223-64-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Fluorocyclohexanone

1.2 Other means of identification

Product number -
Other names 4-fluorocyclohexan-1-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:68223-64-3 SDS

68223-64-3Relevant articles and documents

Photoredox-catalyzed deoxyfluorination of activated alcohols with Selectfluor

González-Esguevillas, María,Miró, Javier,Jeffrey, Jenna L.,MacMillan, David W.C.

supporting information, p. 4222 - 4227 (2019/06/13)

Herein we disclose a deoxyfluorination of alcohols with an electrophilic fluorine source via visible-light photoredox catalysis. This radical-mediated C–F coupling is capable of fluorinating secondary and tertiary alcohols efficiently, complementing previously reported nucleophilic deoxyfluorination protocols.

Method for synthesizing 4-fluorocyclohexanone

-

Paragraph 0044; 0053; 0054; 0055; 0056; 0067-0069;, (2018/05/16)

The invention discloses a method for synthesizing 4-fluorocyclohexanone. The method comprises steps as follows: under the alkaline condition, 1,4-cyclohexanedione monoethylene ketal and a fluorinatingagent are subjected to highly selective reaction, and 8-fluoro-1,4-dioxaspiro[4.5]deca-7-ene is produced; 8-fluoro-1,4-dioxaspiro[4.5]decane is prepared from 8-fluoro-1,4-dioxaspiro[4.5]deca-7-ene and hydrogen under the action of a palladium-carbon catalyst; 8-fluoro-1,4-dioxaspiro[4.5]decane is subjected to deprotection with added acid, and 4-fluorocyclohexanone is obtained. According to the method, 1,4-cyclohexanedione monoethylene ketal which is widely sourced and low in cost is taken as a reaction raw material, a high-purity intermediate can be obtained maximumly in each reaction, so thatthe total yield of the whole reaction is high, purity of a final product is up to 98%, the economic benefit is quite remarkable, less environmental pollution is produced, and the method is particularly suitable for large-scale industrial application and popularization.

NEW BICYCLIC THIOPHENYLAMIDE COMPOUNDS

-

, (2014/01/09)

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, E and n are as described herein, compositions including the compounds and use thereof as fatty-acid binding protein (FABP) 4/5 inhibitors in the treatment of e.g. type 2 diabetes, atherosclerosis or cancer.

Generating rapamycin analogues by directed biosynthesis: Starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids

Goss, Rebecca J. M.,Lanceron, Simon E.,Wise, Nicola J.,Moss, Steven J.

, p. 4071 - 4073 (2008/09/20)

We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin. The Royal Society of Chemistry 2006.

Benzamide derivatives and uses related thereto

-

Page/Page column 52, (2008/06/13)

Benzamide derivatives of formulae I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particularly in the treatment of diabetes, obesity, and related conditions and disorders: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined as provided herein.

Method for preparing aromatic secondary amino compound

-

, (2008/06/13)

Disclosed are (1) a method for preparing an aromatic secondary amino compound which comprises reacting an N-cyclohexylideneamino compound in the presence of a hydrogen moving catalyst and a hydrogen acceptor by the use of a sulfur-free polar solvent and/or a cocatalyst, and (2) a method for preparing an aromatic secondary amino compound which comprises reacting cyclohexanone or a nucleus-substituted cyclohexanone, an amine and a nitro compound corresponding to the amine in a sulfur-free polar solvent in the presence of a hydrogen moving catalyst, a cocatalyst being added or not added. In a further aspect, a method is provided for the preparation of aminodiphenylamine by reacting phenylenediamine and cyclohexanone in the presence of a hydrogen transfer catalyst in a sulfur-free polar solvent while using nitroaniline as a hydrogen acceptor.

Method for preparing aromatic secondary amino compound

-

, (2008/06/13)

Disclosed are (1) a method for preparing an aromatic secondary amino compound which comprises reacting an N-cyclohexylideneamino compound in the presence of a hydrogen moving catalyst and a hydrogen acceptor by the use of a sulfur-free polar solvent and/or a cocatalyst, and (2) a method for preparing an aromatic secondary amino compound which comprises reacting cyclohexanone or a nucleus-substituted cyclohexanone, an amine and a nitro compound corresponding to the amine in a sulfur-free polar solvent in the presence of a hydrogen moving catalyst, a cocatalyst being added or not added.

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