142273-44-7

Basic information

• Product Name: 1,4-Dioxaspiro[4.5]dec-7-ene, 8-fluoro-
• CAS NO: 142273-44-7
• Molecular Formula: C8H11FO2
• Mol File: 142273-44-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1,4-Dioxaspiro[4.5]dec-7-ene, 8-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dioxaspiro[4.5]dec-7-ene, 8-fluoro-(142273-44-7)
• EPA Substance Registry System: 1,4-Dioxaspiro[4.5]dec-7-ene, 8-fluoro-(142273-44-7)

Safety Data

• Hazardous Substances Data: 142273-44-7(Hazardous Substances Data)

Usage

Explanation

Different sources of media describe the Explanation of 142273-44-7 differently. You can refer to the following data:
1. The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 9 carbon (C) atoms, 11 hydrogen (H) atoms, 1 fluorine (F) atom, and 2 oxygen (O) atoms.
2. This is an alternative name for the compound, which is derived from its structure and the presence of a fluorine atom at the eighth carbon atom.
3. Spiroketal compounds are a class of organic compounds that contain a spiro junction, which is a carbon atom shared by two or more rings. In this case, the compound has a 1,4-dioxaspiro moiety.
4. The 1,4-dioxaspiro moiety is a structural feature of the compound, consisting of a six-membered ring with two oxygen atoms at the 1 and 4 positions.
5. The compound has a fluorine atom attached to the eighth carbon atom in the molecule, which is responsible for its alternative name, 8-fluoro-1,4-benzodioxane.
6. The compound is of interest due to its potential use in the development of new drugs and its possible applications in the pharmaceutical and biological industries.
7. The compound may be used as a building block in organic synthesis, which is the chemical synthesis of organic compounds.
8. Due to its potential applications and reactivity, it is important to handle and use this chemical compound with care, adhering to all relevant safety guidelines and regulations to minimize risks.

Structural class

Spiroketal compound

1,4-Dioxaspiro moiety

A six-membered ring with two oxygen atoms

Fluorine atom

Attached to the eighth carbon atom

Potential applications

Pharmaceutical and biological

Use in organic synthesis

As a building block

Safety precautions

Handle with caution, follow safety guidelines and regulations

Upstream product

• 142273-39-0 8-trimethylstannyl-1,4-dioxaspiro[4.5]dec-7-ene 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Downstream Products

• 68223-64-3 4-fluorocyclohexan-1-one 
• 176251-49-3 8,8-difluoro-1,4-dioxaspiro[4,5]decane 

Relevant articles and documents

Aminodifluorosulfinium Tetrafluoroborate salts as stable and crystalline deoxofluorinating reagents

Aminodifluorosulfinium tetrafluoroborate salts were found to act as efficient deoxofluorinating reagents when promoted by an exogenous fluoride source and, In most cases, exhibited greater selectivity by providing less elimination byproduct as compared to DAST and DeoxoFluor. Aminodifluorosulfinium tetrafluoroborates are easy handled crystalline salts that show enhanced thermal stability over dialkylaminosulfur trifluorides, are storage-stable, and unlike DAST and Deoxo-Fluor do not react violently with water.

Method for synthesizing 8,8-difluoro-1,4- dioxaspiro[4.5]decane

The invention discloses a method for synthesizing 8,8-difluoro-1,4-dioxaspiro[4.5]decane. The method comprises the following steps: first, 1,4-cyclohexanedione monoethylene ketal is reacted with a fluorinating agent to form a mixture of 8,8-difluoro-1,4-dioxaspiro[4.5]decane and impurity 8-fluoro-1,4-dioxaspiro[4.5]deca-7-ene; and using a substitute of the mixture and anhydrous hydrofluoric acid to obtain 8,8-difluoro-1,4-dioxaspiro[4.5]decane under the action of the catalyst boron trifluoride complex. In the synthetic method, raw material sources are wide, the price is low, impurities are reutilized by reasonable adding of the catalyst, the production cost is reduced, the production efficiency is improved, raw material and product waste is avoided, the problems of low product yield and low purity are effectively solved, the economic benefit is very obvious, the environmental pollution is small, and the method is especially suitable for large-scale industrial application and promotion.

Deoxofluorination reactions using N,N-disubstituted aminodifluorosulfinium tetrafluoroborate salts

The synthesis of N,N-disubstituted aminodifluorosulfinium tetrafluoroborate salts is reported, and their behavior as deoxofluorinating agent was evaluated. The deoxofluorination reactions were performed using a primary alcohol, a secondary alcohol and a ketone. Results show that subtle modification of the structure of the reagents can noticeably affect the reactivity and the selectivity in deoxofluorination reactions.