- Synthesis method for 2-formyl-3,4-dimethyl-5-acetyl pyrrole
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The invention discloses a synthesis method for 2-formyl-3,4-dimethyl-5-acetyl pyrrole, and belongs to the field of chemical synthesis. The synthesis method comprises the steps that acetic anhydride is taken as a raw material, glacial acetic acid is added into the acetic anhydride, and sodium nitrite is dropwise added by controlling the temperature for a reaction; after the reaction is finished, acetylacetone and zinc powder are added, a reaction is performed after the pH value is regulated, and cooling crystallizing and suction filtering are performed after the reaction is finished; filter residues are cleaned and recrystallized with petroleum ether to obtain 2,5-diacetyl-3,4-dimethyl pyrrole, the 2,5-diacetyl-3,4-dimethyl pyrrole is taken to be dissolved in glacial acetic acid, and sulfuryl chloride is dropwise added into the mixture for a reaction; cooling crystallizing, suction filtering and drying are performed, and then the 2-formyl-3,4-dimethyl-5-acetyl pyrrole is obtained.
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Paragraph 0007
(2016/10/24)
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- Pd-catalyzed enantioselective synthesis of quaternary α-amino acid derivatives using a phenylalanine-derived P-chirogenic diaminophosphine oxide
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A Pd-catalyzed enantioselective synthesis of quaternary α-amino acid derivatives using a phenylalanine-derived P-chirogenic diaminophosphine oxide is described. Asymmetric allylic substitution using acyclic β-keto esters with a nitrogen functional group at the α-carbon as prochiral nucleophiles proceeded in the presence of 5 mol % of Pd catalyst, 10 mol % of chiral diaminophosphine oxide 1j, BSA, and appropriate additives, affording the corresponding quaternary α-amino acid derivatives in excellent yield and in up to 92% ee.
- Nemoto, Tetsuhiro,Harada, Teisuke,Matsumoto, Takayoshi,Hamada, Yasumasa
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p. 6304 - 6307
(2008/02/10)
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