68886-07-7

Basic information

• Product Name: 2-Fluoro-4-hydroxyphenylacetic acid
• Synonyms: 2-Fluoro-4-hydroxyphenylacetic acid;4-HYDROXY-2-FLUOROPHENYLACETIC ACID ;2-fluor-4-hydroxyacetophenone
• CAS NO: 68886-07-7
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.1377832
• Product Categories: Phenylacetic acid
• Mol File: 68886-07-7.mol

Chemical Properties

• Boiling Point: 350.497 °C at 760 mmHg
• Flash Point: 165.775 °C
• Appearance: /
• Density: 1.423
• Vapor Pressure: 1.63E-05mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.22±0.10(Predicted)
• CAS DataBase Reference: 2-Fluoro-4-hydroxyphenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4-hydroxyphenylacetic acid(68886-07-7)
• EPA Substance Registry System: 2-Fluoro-4-hydroxyphenylacetic acid(68886-07-7)

Safety Data

• Hazardous Substances Data: 68886-07-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-4-hydroxyphenylacetic acid is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure, including the fluorine atom and hydroxyl group, allows for the development of new drugs with potential applications in treating different diseases.
Used in Chemical Research:
2-Fluoro-4-hydroxyphenylacetic acid is used as a research compound in the field of organic chemistry. Its properties and reactivity can be studied to understand the effects of fluorine substitution on the chemical behavior of benzene derivatives, which can lead to the discovery of new synthetic methods and applications.
Used in Material Science:
2-Fluoro-4-hydroxyphenylacetic acid is used as a building block in the development of new materials with specific properties. The incorporation of fluorine and hydroxyl groups into the molecule can influence the material's physical and chemical characteristics, making it suitable for various applications in material science.

InChI:InChI=1/C8H7FO3/c9-7-4-6(10)2-1-5(7)3-8(11)12/h1-2,4,10H,3H2,(H,11,12)

Upstream product

• 883531-28-0 2-(2-fluoro-4-methoxyphenyl)acetic acid 
• 1042702-57-7 C₂HF₃O₂*C₁₂H₁₄FNO₄ 
• 372-20-3 3-fluorophenol 
• 78989-55-6 2-fluoro 4-hydroxy mandelic acid 

Downstream Products

• 68886-08-8 diphenylmethyl 4-p-methoxybenzyloxy-2-fluorophenylacetate 
• 91361-59-0 methyl 2-(2-fluoro-4-hydroxyphenyl)acetate 
• 1588944-84-6 2-(2-fluoro-4-hydroxyphenyl)-N ,N-dimethylacetamide 
• 1402555-51-4 1-(azetidin-1-yl)-2-(2-fluoro-4-hydroxyphenyl)ethanone 
• 1437778-75-0 2-[4-((1R,2S)-2-{2-[3-fluoro-4-(1,3,4-thiadiazol-2-ylmethyl)phenoxy]ethyl}cyclopropyl)piperidin-1-yl]-5-(methoxymethyl)pyrimidine 
• 1437779-20-8 2-[2-fluoro-4-(2-{(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidine-2-yl]piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetohydrazide 
• 1437778-71-6 5-chloro-2-{4-[(1R,2S)-2-(2-{3-fluoro-4-[(5-methyl-1,3,4-oxadizol-2-yl)methyl]phenoxy}ethyl)cyclopropyl]piperidin-1-yl}pyrimidine 
• 1437779-19-5 2-[4-(2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethoxy)-2-fluorophenyl]-acetohydrazide 

Relevant articles and documents

P-Hydroxyphenacyl photoremovable protecting groups Robust photochemistry despite substituent diversity

A broadly based investigation of the effects of a diverse array of substituents on the photochemical rearrangement of p-hydroxyphenacyl esters has demonstrated that common substituents such as F, MeO, CN, CO2R, CONH2, and CH3 have little effect on the rate and quantum efficiencies for the photo-Favorskii rearrangement and the release of the acid leaving group or on the lifetimes of the reactive triplet state. A decrease in the quantum yields across all substituents was observed for the release and rearrangement when the photolyses were carried out in buffered aqueous media at pHs that exceeded the ground-state pKa of the chromophore where the conjugate base is the predominant form. Otherwise, substituents have only a very modest effect on the photoreaction of these robust chromophores.

HETEROCYCLIC GPCR AGONISTS

Compounds of formula (I) or pharmaceutically acceptable salts thereof, are GPCR (GPR119) agonists and are useful as for the treatment of diabetes and obesity.

Synthesis and Properties of Optically Active Phenoxypropionates. Effect of Halogeno Substituent in the Core on Physical Properties

Chiral phenoxypropionates having halogenated 2,5-diphenylpyrimidine cores were synthesized and the effect of a halogeno-substituent on the physical properties such as mesomorphic behavior, spontaneous polarization (Ps) and response time (τ) were investigated.The introduction of a halogen atom to the phenyl ring of 2,5-diphenylpyrimidine core led to a decrease in the thermal stability of mesophases.The Ps values in the achiral host liquid crystal mixture were increased by introducing the halogen atom.However, response times were not improved. - Keywords: ferroelectric liquid crystal, phenoxypropionate, halogeno-substituent