- 99mTc-EC-guanine: Synthesis, biodistribution, and tumor imaging in animals
-
Purpose. DNA markers are useful in assessing cell proliferation. The purpose of this study was to synthesize 99mTc-ethylenedicysteine- guanine (EC-Guan) for evaluation of cell proliferation. Methods. Tumor cells were incubated with 99m/su
- Yang, David J.,Ozaki, Kaoru,Oh, Chang-Sok,Azhdarinia, Ali,Yang, Thomas,Ito, Megumi,Greenwell, Allison,Bryant, Jerry,Kohanim, Saady,Wong, Vincenzo K.,Kim, E. Edmund
-
-
Read Online
- METAL RADIOLABELED PET IMAGING AGENTS
-
The invention relates to radiolabeled PET agents including a radioisotope, a chelator and a specific ligand. The radioisotope may include 60Cu, 62Cu, 61Cu, 64Cu and 68Ga. Generator-produced 68Ga radioisotopes may be used. Specific chelators include N2S2 moieties and N3S moieties. Specific ligands may include purine and pyrimidine bases, particularly adenine and guanine, a sugar-containing base, particularly glucosamine, galactosamine, or mannosamine, or a nitroimidazole analogue, such as a 2-nitroimidazole or a 5-nitroimidazole, particularly metronidazole. Radiolabeled agents may be formed by first forming a chelator-ligand complex, which may be stored until it is needed, at which time the radioisotope may be added. Radiolabeled agents may be used in traditional PET imaging or in dynamic PET imaging.
- -
-
Page/Page column 14
(2008/06/13)
-
- N2S2 chelate-targeting ligand conjugates
-
The invention provides, in a general sense, a new labeling strategy employing compounds that are are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor ang
- -
-
Page/Page column 15-16
(2010/02/12)
-
- Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
-
The invention provides, in a general sense, a new labeling strategy employing compounds that are are N2S2 chelates conjugated to a targeting ligand, wherein the targeting ligand is a disease cell cycle targeting compound, a tumor ang
- -
-
-