cas 69674-27-7, 6-bromo-4-methylquinazoline

Articles about 69674-27-7Total 6 be found

SUBSTITUTED ARYL COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
The present application relates to a substituted aryl compound or a pharmaceutically acceptable salt, a stereoisomer, a polymorph, a solvate, a N-oxide, an isotope-labeled compound, a metabolite or a prodrug thereof, and a preparation method therefor and use thereof, also relates to a pharmaceutical composition containing the compound and a therapeutic use thereof. The compound or a pharmaceutical composition thereof can inhibit the activity of adenosine A2a receptor, and can be used for treating or preventing a disease related to adenosine A2a receptor, especially for treating a tumor.
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Paragraph 0190

(2021/11/04)

SUBSTITUTED IMIDAZOLES FOR THE INHIBITION OF TGF-BETA AND METHODS OF TREATMENT
This disclosure relates to low molecular weight substituted imidazoles that inhibit the TGF-b signaling pathway. More specifically, this disclosure relates to methods of using said imidazoles for the treatment of diseases related to the TGF-b signaling pathways including, but not limited to, atherosclerosis, Marfan syndrome, Loeys-Dietz syndrome, obesity, diabetes, multiple sclerosis, keratoconus, idiopathic pulmonary fibrosis, Alzheimer's Disease, chronic kidney disease, and scleroderma.
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Paragraph 00111-00112

(2020/03/15)

Substituted pyrazine compound as well as preparation method and application thereof
The invention discloses a substituted pyrazine compound as an adenosine receptor antagonist, a preparation method and an intermediate thereof, a pharmaceutical composition containing the substituted pyrazine compound, and a therapeutic application of the
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Paragraph 0240; 0241; 0242-0244

(2020/07/24)

Aminopyrimidine compound and preparation method and application thereof
The invention relates to an aminopyrimidine compound and a preparation method and application thereof, in particular to an aminopyrimidine compound shown as a formula (I) or pharmaceutically acceptable salts thereof, a stereoisomer, a tautomer, a polymorph, a solvate, an N-oxide, an isotope labeled compound, a metabolite or a prodrug, a pharmaceutical composition containing the compound, a preparation method of the compound and application of the compound to prevention or treatment of adenosine A2a receptor related diseases.
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Paragraph 0226; 0227; 0228; 0229; 0230

(2020/07/24)

2-amino pyrimidine derivative, preparation method thereof and application thereof in medicine
The invention relates to 2-amino pyrimidine derivative, a preparation method thereof and an application thereof in medicine. In particular, the present invention relates to a 2-amino pyrimidine derivative shown in the general formula (I), a preparation method thereof, a pharmaceutical composition containing that derivative and use thereof as therapeutic agent, in particular as an A2a receptor and/or A2b receptor antagonist and in the preparation of a drug for the treatment of a condition or disorder improved by inhibition of the A2a receptor and/or A2b receptor, wherein the substituents of thegeneral formula (I) are the same as defined in the specification.
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Paragraph 0191; 0194-0198

(2020/02/08)

1,2,4-TRIAZINE-3-AMINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE
The present invention relates to a 1,2,4-triazine-3-amine derivative, a preparation therefor, and use thereof in medicine. Specifically, the present invention relates to a 1,2,4-triazine-3-amine derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and use thereof as a therapeutic agent, in particular as an A2a receptor antagonist, and use thereof in the preparation of a medicament for treating a condition or disorder that is ameliorated by means of inhibition of the A2a receptor, each substituent in general formula (I) being same as defined in the description.
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Paragraph 0125; 0179; 0180

(2019/11/28)