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2H-3,1-Benzoxazin-2-one,1,4-dihydro-5-methoxy-4,4-dimethyl-(9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

697801-52-8

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697801-52-8 Usage

Main properties

1. Chemical formula: C11H13NO3
2. Derivative of benzoxazinone
3. Heterocyclic compound
4. Contains a methoxy and two methyl groups

Specific content

Used in pharmaceutical and research applications
Potential pharmacological properties as an antimicrobial agent and potential anti-inflammatory activity
Potential as a natural product for crop protection against pests and diseases

Check Digit Verification of cas no

The CAS Registry Mumber 697801-52-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,7,8,0 and 1 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 697801-52:
(8*6)+(7*9)+(6*7)+(5*8)+(4*0)+(3*1)+(2*5)+(1*2)=208
208 % 10 = 8
So 697801-52-8 is a valid CAS Registry Number.

697801-52-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-methoxy-4,4-dimethyl-1H-3,1-benzoxazin-2-one

1.2 Other means of identification

Product number -
Other names 5-Methoxy-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:697801-52-8 SDS

697801-52-8Relevant articles and documents

Aryl Substituted Benzimidazolones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

Pribut, Nicole,Basson, Adriaan E.,Van Otterlo, Willem A. L.,Liotta, Dennis C.,Pelly, Stephen C.

, p. 196 - 202 (2019/02/05)

Since the discovery of HIV as the etiological agent of AIDS, the virus has infected millions of people each year. Fortunately, with the use of HAART, viremia can be suppressed to below detectable levels in the infected individuals, which significantly improves their quality of life and prevents the onset of AIDS. However, HAART is not curative and issues relating to adherence and drug resistance may lead to the re-emergence of viremia, the development of AIDS, and ultimately death. To address a pressing need for the development of new and efficacious antiretroviral agents with activity against viruses bearing prevalent resistant mutations, we have designed two generations of benzimidazolone derivatives as HIV non-nucleoside reverse transcriptase inhibitors. The first generation benzimidazolone inhibitors were found to be potent inhibitors of wild-type HIV reverse transcriptase but were ineffective in the presence of common resistance mutations such as K103N and Y181C. A second generation benzimidazolone inhibitor (compound 42) not only showed inhibitory activity against wild-type HIV but also remained active against HIV containing the K103N, Y181C, and K103N/Y181C drug resistance mutations.

Non-nucleoside reverse transcriptase inhibitors

-

Page 15, (2010/02/07)

Compounds represented by formula I: wherein R1 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R2 is H or (C1-4)alkyl; R3 is H or (C1-4)alkyl; R4 is (C1-4)alkyl, (C1-4)alkyl(C3-7)cycloalkyl, or (C3-7)cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q being optionally substituted with hydroxy, or (C1-4)alkyl which in turn maybe optionally substituted with pyridinyl-N-oxide or C(O)OR wherein R is H or (C1-4)alkyl; or a salt thereof. The compounds have inhibitory activity against Wild Type, and single and double mutants strains, of HIV.

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