- Synthesis of 2-Methoxy-4-(methylsulfanyl)benzoic Acid — An Intermediate Product in the Preparation of the Cardiotonic Drugs Sulmazole and Isomazole
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Readily available 4-methyl-3-nitrobenzenesulfonic acid and 2-methyl-5-nitrophenol were used to develop two alternative approaches to the synthesis of 2-methoxy-4-(methylsulfanyl)benzoic acid in total yields of 17% and 37%, respectively. The synthesis starting from 2-methyl-5-nitrophenol is more process-oriented and can be used in the resynthesis of Sulmazole and Isomazole.
- Lomov
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- Sulfonation of 1,2-(methylenedioxy)benzene, 1,2-(ethylenedioxy)benzene, 2-methylanisole, 2,3-dihydrobenzofuran, chromane, benzo-15-crown-5 and dibenzo-30-crown-10 in concentrated sulfuric acid and with sulfur trioxide
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The sulfonation of 1,2-(methylenedioxy)benzene (2), 1,2-(ethylenedioxy)benzene (3), benzo-15-crown-5 (4), 2-methylanisole (5), 2,3-dihydrobenzofuran (7), 2,3-dihydrobenzopyran (chromane, 8) and dibenzo-30-crown-10 (9) in concentrated sulfuric acid and wit
- Ansink, Harold,Cerfontain, Hans
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p. 395 - 403
(2007/10/02)
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