7468-67-9

Basic information

• Product Name: 2-Cyanobenzaldehyde
• Synonyms: O-CYANOBENZALDEHYDE;2-CYANOBENZALDEHYDE;2-FORMYLBENZONITRILE;2-Cyanobenaldehyde;Phthalaldehydonitrile;2-Cyanobenzaldehyde,98%;2-Cyanobenzaldehyde, 98% 5GR;2-Cyanobenzaldehyde 98%
• CAS NO: 7468-67-9
• Molecular Formula: C₈H₅NO
• Molecular Weight: 131.13
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Aldehydes;C8;Carbonyl Compounds;Aromatics;Cross Linking Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 7468-67-9.mol

Chemical Properties

• Melting Point: 103-105 °C(lit.)
• Boiling Point: 284.919 °C at 760 mmHg
• Flash Point: 126.115 °C
• Appearance: White to orange to beige/Powder, Crystals and/or Chunks
• Density: 1.155 g/cm³
• Vapor Pressure: 0.00289mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly, Sonicated), Chloroform (Slightly)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-Cyanobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyanobenzaldehyde(7468-67-9)
• EPA Substance Registry System: 2-Cyanobenzaldehyde(7468-67-9)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39-36/37/39-36
• RIDADR: UN 3439 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 7468-67-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Cyanobenzaldehyde is used as a crosslinker for protein kinase, which plays a crucial role in numerous phosphorylation events in the phosphoproteome. This application is significant in the development of drugs targeting protein kinase-related diseases.
Used in Chemical Synthesis:
2-Cyanobenzaldehyde is utilized in the base-catalyzed one-pot synthesis of 3-substituted isoindolinones, which are important intermediates in the synthesis of various pharmaceuticals and organic compounds.
Used in Organic Chemistry:
It is also used in the synthesis of 3-oxo-2,3-dihydro-1H-isoindoles, via the Baylis-Hillman reaction, which is a versatile method for the formation of carbon-carbon bonds and the synthesis of complex organic molecules.
Used in Synthesis of Isoindolenones:
2-Cyanobenzaldehyde is employed in the synthesis of 3-(N-substituted amino)-1-isoindolenones, which are valuable building blocks for the creation of various organic compounds and pharmaceuticals.
Used in Biotransformation:
The biotransformation of 2-Cyanobenzaldehyde by Euglena gracilis Z, cultured photohetero-trophically, has been reported. This process highlights the potential of using microorganisms for the synthesis and modification of organic compounds, including 2-Cyanobenzaldehyde.

InChI:InChI=1/C8H5NO/c9-5-7-3-1-2-4-8(7)6-10/h1-4,6H

Upstream product

• 2886-29-5 trans-3-(2-cyanophenyl)propenoic acid 
• 89942-45-0 2-(hydroxymethyl)benzenecorbonitrile 
• 655-63-0 2-(dibromomethyl)benzonitrile 
• 153657-11-5 2-diacetoxymethyl-benzonitrile 
• 13612-59-4 cyclohepta-2,4,6-triene-1-carbonitrile 
• 460-19-5 ethanedinitrile 
• 100-52-7 benzaldehyde 
• 201230-82-2 carbon monoxide 
• 100-47-0 benzonitrile 
• 22115-41-9 2-(bromomethyl)benzonitrile 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 253-52-1 PHTHALAZINE 
• 27510-48-1 (Z)-3-(2-cyanophenyl)prop-2-enoic acid 
• 138313-23-2 2-<(trifluoromethanesulfonyl)oxy>benzonitrile 

Downstream Products

• 464181-66-6 (E)-3-(2-cyanophenyl)-2-phenylpropenoic acid 
• 412025-73-1 2-(α-hydroxy-benzyl)-benzophenone-imine 
• 2886-29-5 trans-3-(2-cyanophenyl)propenoic acid 
• 6306-97-4 1,3-bis(4-methoxyphenyl)isobenzofuran 
• 6335-81-5 2-[(4-bromo-phenylhydrazono)-methyl]-benzonitrile 
• 32855-63-3 3-(5-oxo-2-phenyl-4,5-dihydro-3H-naphtho[1,8-bc]furan-4-yl)-2,3-dihydro-isoindol-1-one 
• 91398-95-7 2-Cyano-benzyliden-bis-chloracetamid 
• 80659-97-8 5,10,15,20-tetrakis(o-cyanophenyl)porphyrin 
• 130557-53-8 5-(o-cyanophenyl)-10,15,20-triphenylporphyrin 
• 26487-02-5 3-ethoxy-2,3-dihydro-1H-isoindol-1-one 
• 75206-24-5 2-[1-(2-Cyano-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-chloro-ethyl ester 
• 75206-26-7 2-[1-(2-Cyano-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-ethoxy-ethyl ester 
• 75206-28-9 2-[1-(2-Cyano-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-phenoxy-ethyl ester 
• 75206-29-0 2-[1-(2-Cyano-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 2-benzyloxy-ethyl ester 

Relevant articles and documents

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