7480-80-0

Basic information

• Product Name: 5-METHYL-1H-INDENE
• Synonyms: 5-METHYL-1H-INDENE;5-methylindene;indene,5-methyl-
• CAS NO: 7480-80-0
• Molecular Formula: C₁₀H₁₀
• Molecular Weight: 130.19
• EINECS: 231-286-7
• Mol File: 7480-80-0.mol

Chemical Properties

• Boiling Point: 209.1 °C at 760 mmHg
• Flash Point: 73.1 °C
• Appearance: /
• Density: 1.016 g/cm³
• Vapor Pressure: 0.298mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 5-METHYL-1H-INDENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-1H-INDENE(7480-80-0)
• EPA Substance Registry System: 5-METHYL-1H-INDENE(7480-80-0)

Safety Data

• Hazardous Substances Data: 7480-80-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10/c1-8-5-6-9-3-2-4-10(9)7-8/h2,4-7H,3H2,1H3

Upstream product

• 24623-20-9 2,3-dihydro-6-methyl-1H-inden-1-one 
• 200425-63-4 (+/-)-6-Methyl-1-indalol 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 55394-81-5 3-(4-bromophenyl)propanoyl chloride 
• 92013-18-8 2-[(4-bromophenyl)methyl]propanedioic acid 
• 75476-86-7 6-Bromo-2,3-dihydro-1H-inden-1-ol 
• 14548-39-1 6-bromoindan-1-one 
• 70146-78-0 diethyl 2-(4-bromobenzyl)malonate 
• 1643-30-7 3-(4-bromophenyl)propionic acid 
• 75-16-1 methylmagnesium bromide 
• 75476-78-7 5-bromo-1H-indene 

Downstream Products

• 1255922-77-0 5-methyl-2-(2-oxoethyl)benzaldehyde 
• 54004-38-5 7-methyl isoquinoline 

Relevant articles and documents

AuCl3-Catalyzed Ring-Closing Carbonyl–Olefin Metathesis

Compared with the ripeness of olefin metathesis, exploration of the construction of carbon–carbon double bonds through the catalytic carbonyl–olefin metathesis reaction remains stagnant and has received scant attention. Herein, a highly efficient AuCl3-catalyzed intramolecular ring-closing carbonyl–olefin metathesis reaction is described. This method features easily accessible starting materials, simple operation, good functional-group tolerance and short reaction times, and provides the target cyclopentenes, polycycles, benzocarbocycles, and N-heterocycle derivatives in good to excellent yields.

Total Synthesis of Anmindenol A and Its Application to the Design, Synthesis, and Biological Evaluation of Derivatives Thereof

The first total synthesis of anmindenol A is described in four steps. A notable feature of the synthetic route includes the efficient construction of the 3,10-dialkylsubstituted benzofulvene core via a stereoselective vinylogous Stork enamine aldol condensation. The strategy provided a blueprint for the practical preparation of derivatives with modifications in the C-10 alkyl substituents. The novel derivatives inhibited nitric oxide production in stimulated RAW 264.7 macrophage cells.

New Synthetic Method of 3,10-disubstituted benzofulvene derivatives

The present invention relates to a novel synthesis method of 3,10-disubstituted benzofulvene derivatives which is excellent in an economic aspect since the yield is excellent. The novel synthesis method comprises the steps of: synthesizing an indene derivative having an enamine substituent; synthesizing an intermediate compound represented by chemical formula A; synthesizing an intermediate compound represented by chemical formula B; and synthesizing a 3,10-disubstituted benzofulvene derivative represented by chemical formula 3.COPYRIGHT KIPO 2020

Carbocation catalysed ring closing aldehyde-olefin metathesis

A highly efficient aldehyde-olefin metathesis catalysed by the carbocation, 4-phenylphenyl-diphenylmethylium ion, has been developed. This protocol is characterized by high yields, low catalyst loading (down to 2 mol%), good functional group compatibility and mild reaction conditions.

Acid catalysed reaction of indanones, tetralones and benzosuberone with neopentyl glycol and other alkanediols under forced conditions

Upon reaction with an excess of 2,2-dimethylpropane-1,3-diol (neopentyl glycol, NPG) under acid catalysis, indanones and tetralones yield indenes and dihydronaphthalenes, respectively. The reaction can also be carried out with butane-1,3-diol.

A facile method for synthesis of polysubstituted naphthalene derivatives through pyrrolidine catalyzed domino reaction

A novel synthetic method for polysubstituted naphthalene derivatives via a pyrrolidine-mediated cascade Michael/Henry reaction was developed, in which easily prepared 2-(2-oxoethyl)benzaldehydes and nitroalkenes were employed as the starting materials. The reaction consists of four consecutive reactions that include a cascade Michael/Henry reaction, a dehydration reaction, and an aromatization reaction in one pot to afford synthetically important naphthalene derivatives with moderate yields.

C-GLYCOSIDE DERIVATIVES AND SALTS THEREOF

The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via -X- and A ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.

Process for preparing cyclopentadienyl group-containing silicon compound or cyclopentadienyl group-containing germanium compound

Disclosed is a process for preparing a cyclopentadienyl group-containing silicon compound or a cyclopentadienyl group-containing germanium compound, comprising reacting (i) a lithium, sodium or potassium salt of a cyclopentadiene derivative with (ii) a silicon halide compound or a germanium halide compound in the presence of a cyanide or a thiocyanate. The cyanide or the thiocyanate is preferably a copper salt. According to the process of the invention, a cyclopentadienyl group-containing silicon compound or a cyclopentadienyl group-containing germanium compound, which is very useful for the preparation of a metallocene complex catalyst component, can be prepared in a high yield for a short period of time.

Dehydrocyclization of polysubstituted cyclic organic compounds over copper aluminum borate

A dehydrocyclization process is described for producing polynuclear organic compounds by contacting a starting organic material having at least one ring moiety comprising at least two adjacent ring carbon atoms each bonded to an independently selected monovalent radical comprising at most about eight carbon atoms provided at least one of the monovalent hydrocarbon radicals comprises more than one carbon atom with a crystalline copper aluminum borate catalyst. The preferred catalyst comprises at least one member selected from the group consisting of (a) crystalline copper aluminum borate and (b) zero valent copper on a support comprising at least one member selected from the group consisting of Al4 B2 O9 and the crystalline copper aluminum borate, the zero valent copper on the support being formed by the reduction of the crystalline copper aluminum borate. The process is conducted under conditions sufficient to effect cyclization between (i) a carbon atom of one of the radicals and (ii) a carbon atom of the other radical forming a dehydrocyclization product comprising a polynuclear compound wherein the new ring comprises at least 5 carbon atoms.

Synthesis of Biological Markers in Fossil Fuels. 2. Synthesis and 13C NMR Studies of Substituted Indans and Tetralins

Unambiguous syntheses of all possible methyl, ethyl, n-propyl, and n-butyl derivatives of indan and tetralin were developed using the Kumada coupling procedure involving the reaction of aryl or vinyl halides with Grignard reagents in the presence of nickel(II) chloride.An analysis of the 13C NMR spectra of these compounds was also completed.