75476-78-7Relevant academic research and scientific papers
Use of oxirane ring-opening reactions for synthesis of ethylene- bis(indenyl) ligands containing alkene tethers
Panarello, Anthony P.,Vassylyev, Oleksiy,Khinast, Johannes G.
, p. 797 - 800 (2005)
An efficient strategy is presented for the synthesis of novel bis-indenyl ligands containing alkene tethers for their further immobilization. The tether was attached to a bridge or aromatic ring of the ligand. The ligands were prepared using oxirane ring-opening reaction.
SPIROCYCLIC PIPERIDINE MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF
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Paragraph 00359, (2021/07/02)
Described herein are compounds that are melanocortin subtype-2 receptor (MC2R) modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of MC2R activity.
Total Synthesis of Anmindenol A and Its Application to the Design, Synthesis, and Biological Evaluation of Derivatives Thereof
Jo, Jeyun,Jeong, Myeonggyo,Ahn, Ji-Su,Akter, Jinia,Kim, Hyung-Sik,Suh, Young-Ger,Yun, Hwayoung
, p. 10953 - 10961 (2019/09/09)
The first total synthesis of anmindenol A is described in four steps. A notable feature of the synthetic route includes the efficient construction of the 3,10-dialkylsubstituted benzofulvene core via a stereoselective vinylogous Stork enamine aldol condensation. The strategy provided a blueprint for the practical preparation of derivatives with modifications in the C-10 alkyl substituents. The novel derivatives inhibited nitric oxide production in stimulated RAW 264.7 macrophage cells.
New Synthetic Method of 3,10-disubstituted benzofulvene derivatives
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Paragraph 0070; 0108; 0125-0127, (2020/01/07)
The present invention relates to a novel synthesis method of 3,10-disubstituted benzofulvene derivatives which is excellent in an economic aspect since the yield is excellent. The novel synthesis method comprises the steps of: synthesizing an indene derivative having an enamine substituent; synthesizing an intermediate compound represented by chemical formula A; synthesizing an intermediate compound represented by chemical formula B; and synthesizing a 3,10-disubstituted benzofulvene derivative represented by chemical formula 3.COPYRIGHT KIPO 2020
LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE
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, (2016/10/07)
PROBLEM TO BE SOLVED: To provide a liquid crystal compound, a liquid crystal composition, and a liquid crystal device using the compound or the composition. SOLUTION: The liquid crystal compound is represented by formula (I). In formula (I), R1 represents H, an alkyl having 1 to 10 carbon atoms, or the like; R2 represents an alkenyl having 2 to 10 carbon atoms or a fluoroalkenyl having 2 to 10 carbon atoms and one or two non-adjacent -CH2- in R2 is replaced by -O- or an ether having 2 to 10 carbon atoms; A1 to A4 each independently represent a formula below, where R3 independently represents H or a halogen; Z1 to Z3 each independently represents a sing bond, -CH2-, -CH2O-, -OCH2-, -CF=CF-, -COO-, -OCO-, -CF2O-, -OCF2-, -C≡C-, -CH=CH-, or the like; and n and m each independently represent 0 or 1. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
A facile method for synthesis of polysubstituted naphthalene derivatives through pyrrolidine catalyzed domino reaction
Li, Shi-Guang,Hu, Xiu-Qin,Jia, Zhen-Xin,Xu, Peng-Fei
supporting information; scheme or table, p. 8557 - 8561 (2010/11/05)
A novel synthetic method for polysubstituted naphthalene derivatives via a pyrrolidine-mediated cascade Michael/Henry reaction was developed, in which easily prepared 2-(2-oxoethyl)benzaldehydes and nitroalkenes were employed as the starting materials. The reaction consists of four consecutive reactions that include a cascade Michael/Henry reaction, a dehydration reaction, and an aromatization reaction in one pot to afford synthetically important naphthalene derivatives with moderate yields.
Selective alkylation and Suzuki coupling as an efficient strategy for introducing functional anchors to the ethylene-bis(indenyl) ligand
Panarello, Anthony P.,Vassylyev, Oleksiy,Khinast, Johannes G.
, p. 1353 - 1356 (2007/10/03)
Chiral ansa-ethylene-bis(indenyl)-metal complexes, EBI-MX2, are useful pre-catalysts for a wide variety of reactions, including hydrogenations, hydrosilylations, and polymerization reactions. In order to immobilize these complexes onto heterogeneous supports, a new methodology was developed to introduce functional anchors to the ethylene-bis(indenyl) ligand, EBI. This was accomplished by selective alkylation of indene to form toluene-4-sulfonic acid 2-(3H-inden-1-yl)-ethyl ester, which was then used to alkylate 6-bromoindene. The selective introduction of an aryl bromide then undergoes coupling reactions with aryl borates via the Suzuki coupling to efficiently introduce an alkenyl or alcohol, functional anchor in a simple four step synthesis.
Stereochemical and mechanistic aspects of dioxygenase-catalysed benzylic hydroxylation of indene and chromane substrates
Boyd, Derek R.,Sharma, Narain D.,Bowers, Nigel I.,Boyle, Rosemary,Harrison, John S.,Lee, Kyoung,Bugg, Timothy D.H.,Gibson, David T.
, p. 1298 - 1307 (2007/10/03)
Toluene dioxygenase (TDO)-catalysed benzylic hydroxylation of indene substrates (8, 16 and 17), using whole cell cultures of Pseudomonas putida UV4, was found to yield inden-1-ol (14 and 223) and indan-1-one bioproducts (15 and 23). The formation of these bioproducts is consistent with the involvement of carbon-centred radical intermediates. TDO-catalysed oxidation of indenes 8 and 16 also gave cis-diols 13 and 18 respectively. TDO and naphthalene dioxygenase (NDO), used as both whole-cell preparation and as purified enzymes, were found to catalyse the benzylic hydroxylation of chromane 30, deuteriated (±)-chromane 30D and enantiomers (4S)-30D and (4R)-30D to yield (4R)- and (4S)-chroman-4-ols 31/31D respectively. The mechanism of benzylic hydroxylation of chromane 30/30D involves the stereoselective abstraction of a pro-R (with TDO) or a pro-S (with NDO) hydrogen atom at C-4 and a marked preference for retention of configuration.
LIGANDS AND CATALYSTS FOR PRODUCING ELASTOMERIC PROPYLENE POLYMERS
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, (2008/06/13)
A ligand useful to form a metallocene olefin polymerization catalyst comprises:wherein at least R3 and R4 are substituents having at least a bulk of a t-butyl group and, optionally, wherein R1 or R2 may be a bulky substituent group.
Thrombin inhibitors based on [5,5] trans-fused indane lactams
Pass, Martin,Abu-Rabie, Said,Baxter, Andrew,Conroy, Richard,Coote, Steven J.,Craven, Andrew P.,Finch, Harry,Hindley, Sean,Kelly, Henry A.,Lowdon, Andrew W.,McDonald, Edward,Mitchell, William L.,Pegg, Neil A.,Procopiou, Pan A.,Ramsden, Nigel G.,Thomas, Rhian,Walker, Dawn A.,Watson, Nigel S.,Jhoti, Harren,Mooney, Christopher J.,Tang, Chi-Man,Thomas, Pamela J.,Parry, Simon,Patel, Champa
, p. 1657 - 1662 (2007/10/03)
A series of trans-fused lactams containing the indane nucleus has been prepared. Compound 19 has much enhanced plasma stability compared with its lactone counterpart and shows appreciable in vitro anticoagulant activity.
